Endocrine Abstracts

Prolactinomas are the most common hormone-secreting pituitary tumors. They have good response for conservative treatment. In the time of diagnosis large pituitary tumors unrarely can cause hypopituitarism. We have two cases of partially or totally recovery of hypopituitarism in consequence of effective dopamine agonists use. The 24-years man with large prolactinoma (prolactin 52 times higher) and laboratory markers of panhypopituitarism had total recovery in 1 year of cabergol...

Introduction: Prolactinomas are the most common tumors among hormonally active pituitary adenomas. Therapy with dopamine agonists (DA) remains the first treatment choice. However there remain definite numbers of prolactinomas resistant to standard DA therapy. The underlying mechanisms of this phenomenon, management and prognosis are still poorly understood. The search of treatment options for overcoming DA-resistance is an important object in practical endocrinology. We presen...

Introduction: The combination of poly/monostotis fibrous dysplasia, café-au-lait pigmentation of the skin and endocrine hyperfunction (mostly precocious puberty) is known as McCune–Albright syndrome (MAS), a genetic origin syndrome with low incidence. The molecular basis of MAS is a mosaic activating mutation of the α subunit of the G protein (Gsα) gene.We present a clinical case of a 10-year-old boy with partial MAS and GH-secreting ...

Diabetes mellitus (DM) is accompanied with a variety of metabolic changes in different systems including bone. In several previous studies it was shown that DM type 1 is associated with a decreased mineral density, whereas the data regarding DM type 2 are still controversial.In the present study we examined the risk of different bone fractures in diabetic patients visiting local trauma clinic during one year (total area population 50.500). The incidence ...