ea0059p178 | Reproduction | SFEBES2018
Lucas Herald Angela
, Alves-Lopes Rheure
, Haddow Laura
, O'Toole Stuart
, Basith Amjad Syed
, Flett Martyn
, Steven Mairi
, Lee Boma
, Montezano Augusto
, Faisal Ahmed Syed
, Touyz Rhian M.
Background: Hypospadias in boys may be associated with a lack of androgen exposure during the masculinisation programming window. As testosterone has effects on the vasculature, we assessed whether boys with hypospadias show evidence of vascular dysfunction.Methods: Excess foreskin tissue was obtained from boys undergoing hypospadias repair (cases) or circumcision (controls) and small arteries dissected. Vascular contractility was assessed by wire myogra...