Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2018

Glasgow, UK
19 Nov 2018 - 21 Nov 2018

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The Society for Endocrinology BES will take place 19-21 Nov 2018 in Glasgow. Come and exchange knowledge, share experiences and strengthen collaborations across our global community of endocrinologists.

Poster Presentations


ea0059p177 | Reproduction | SFEBES2018

Naringenin inhibits progression, proliferation and induces apoptosis via ROS generation in endometriotic lesions in rats

Kapoor Radhika , Kumar Sirohi Vijay , Gupta Kanchan , Dwivedi Anila

Endometriosis is one of the commonly occurring disorders of reproductive women, which represents attachment of functional endometrial cells and tissue outside the uterine cavity, culminates into infertility. This invasive disorder is still under quest for novel treatment strategies. Naringenin is a plant-derived flavonoid having anti-proliferative, anti-inflammatory, and anti-angiogenic properties in chronic and metabolic diseases. The study was planned with an objective to de...

ea0059p178 | Reproduction | SFEBES2018

Altered vascular function in boys with hypospadias- role of reactive oxygen species

Lucas Herald Angela , Alves-Lopes Rheure , Haddow Laura , O'Toole Stuart , Basith Amjad Syed , Flett Martyn , Steven Mairi , Lee Boma , Montezano Augusto , Faisal Ahmed Syed , Touyz Rhian M.

Background: Hypospadias in boys may be associated with a lack of androgen exposure during the masculinisation programming window. As testosterone has effects on the vasculature, we assessed whether boys with hypospadias show evidence of vascular dysfunction.Methods: Excess foreskin tissue was obtained from boys undergoing hypospadias repair (cases) or circumcision (controls) and small arteries dissected. Vascular contractility was assessed by wire myogra...

ea0059p179 | Reproduction | SFEBES2018

The effectiveness of management of pregnant women with type 1 diabetes mellitus with continuous subcutaneous insulin infusion

Skriplionak Tatsiana , Mokhort Tatsiana

Aim: Assess the effectiveness of management of pregnant women with type 1 diabetes mellitus (DM 1) with continuous subcutaneous insulin infusion (CSII).Materials and Methods: Pregnant women with DM 1 with CSII (n=21) - the main group and on multiple daily insulin injections (MDI) (n=216) - the comparison group. We used different models of the Medtronic pumps. The inclusion in the comparison group carried out by a continuous method. The ...

ea0059p180 | Reproduction | SFEBES2018

Aortic growth in Turner syndrome is accellerated compared with general population

Calanchini Matilde , Orchard Elizabeth , Bradley-Watson Jason , Fabbri Andrea , Turner Helen E

Introduction: Women with Turner syndrome (TS) have an increased risk of aortic dissection. Aortic dilatation, bicuspid aortic valve (BAV) and hypertension confer increased risk of dissection. However, only some women with these risk factors develop dissection, and others with no risk markers may dissect. Knowledge of the development of the aortopathy over time is limited. We investigate aortic dimension changes in unselected adult TS and associations between aortic growth and ...

ea0059p181 | Reproduction | SFEBES2018

Gonadectomy for adults with DSD conditions at risk of hypogonadism in the international disorders of sex development registry

Herald Angela Lucas , Kyriakou Andreas , Bryce Jillian , Rodie Martina , Acerini Carlo , Arlt Wiebke , Balsamo Antonio , Baronico Federico , Bertelloni Silvano , Brooke Antonia , van der Grinten Hedi Claahsen , Cools Martine , Darendeliler Feyza , Davies Justin H , Desloovere An , Ellaithi Mona , Fica Simona , Gawlik Aneta , Guran Tulay , Hannema Sabine , Hiort Olaf , Holterhus Paul-Martin , Iotova Violeta , Jennane Farida , Lachlan Katherine , Li Dejun , Lisa Lidka , Mazen Inas , Mladenov Wilchelm , Mohnike Klaus , Nedelea Lavnia , Niedziela Marek , Nordenstrom Anna , Poyrazoglu Sukran , Rey Rodolfo , Tadokoro-Cuccaro Rieko , Weintrob Naomi , Ahmed Syed Faisal

Introduction: Disorders of Sex Development (DSD) can be associated with an increased risk of germ cell tumours depending on the underlying diagnosis. To date however knowledge regarding the indications and timing of gonadectomy is lacking.Methods: The I-DSD Registry was interrogated for anonymised information regarding the diagnosis, karyotype, sex of rearing and timing of gonadectomy, if undertaken, of all individuals of any karyotype who were over the ...

ea0059p182 | Reproduction | SFEBES2018

Elongated transverse aortic arch in Turner syndrome: a useful marker for cardiovascular risk?

Calanchini Matilde , Mc Millan Fiona , Orchard Elizabeth , Myerson Saul , Turner Helen E

Introduction: Elongated transverse aortic arch (ETA) has recently been described as the commonest abnormality (≅50%) in Turner syndrome (TS), exceeding the prevalence of bicuspid aortic valve (BAV; 10–30%) and aortic coarctation (CoA; 7–18%). Nevertheless only few studies focused on ETA. ETA was associated with BAV, CoA, 45,X and aortic dilatation.Aim: To evaluate the prevalence and associations of ETA in adult TS, unselected for cardiova...

ea0059p183 | Reproduction | SFEBES2018

Impact of ethnicity on the change in total testosterone, haematocrit and prostate-specific antigen with Testosterone undecanoate treatment

Kempegowda Punith , Quinn Lauren , Rayachaudhari Anupama , Shepherd Lisa , Kauser Samina , Chandan Joht Singh , Thomas Tom , Rahim Asad , Bates Andrew

Background: Current guidelines recommend regular monitoring of total testosterone, haematocrit and prostate-specific antigen (PSA) when androgen-deficient males are commenced on testosterone replacement therapy (TRT). The aim is to restore serum total testosterone to the mid-normal range, whilst maintaining haematocrit and PSA at the recommended levels. Limited studies have assessed the impact of ethnicity on these biochemical parameters.Aim: To measure ...

ea0059p184 | Reproduction | SFEBES2018

Where Are They Now? Review of patients diagnosed with Disorders of Sex Development since 1988

Kanani Hina , Bagheri Kimiya , Fews Graham , Allen Stephanie , Idkowiak Jan , Kirk Jeremy , Krone Nils P , Latthe Pallavi , Mohamed Zainaba , Cole Trevor , Gleeson Helena

Background: As diagnostic workup and management of patients with Disorders of Sex Development (DSD) evolves, access to the latest advances should continue.Aims: To explore whether DSD patients in the West Midlands Region (WMR) remain under follow up, having optimal diagnostic workup and management.Method: An unselected cohort of 48 patients with discrepant phenotypic gender and sex chromosomes in the WMR were identified from the re...

ea0059p185 | Reproduction | SFEBES2018

Managment of women with premature ovarian insufficiency: a multi-disciplinary review of practice

Richardson Alison , Haridass Sabari , Ward Emma , Ayres Julie , Baskind Ellissa

Introduction: Women with premature ovarian insufficiency (POI) may complain of various symptoms and consequently be seen by clinicians in a range of settings. Management is multifactorial and may vary depending on the awareness of practitioners within each specialty/subspecialty. In 2015, the European Society for Human Reproduction and Embryology (ESHRE) published guidelines on the management of POI. These state that women should have the following investigations: karyotype; s...

ea0059p186 | Reproduction | SFEBES2018

Hormone replacement therapy and cognition in menopause

Tzanninis Stamatios , Adamson Karen

Background: Menopause marks the permanent cessation of periods for a woman. It is commonly associated with cognitive impairment. Oestrogens and progestins have been known to have a profound effect on the central nervous system and can exert neuroprotective effects on the cellular level. This led to the hypothesis that administration of oestrogens, progestins or a combination of both in the form of hormone replacement therapy (HRT) can have a protective or therapeutic effect ag...

ea0059p187 | Reproduction | SFEBES2018

A prospective study of testicular development and function in boys with Duchenne Muscular Dystrophy

Denker M , Joseph S , DiMarco M , Dunne J , Horrocks I , Ahmed SF , Wong SC

Introduction: There is a need to understand testicular development in adolescents with Duchenne Muscular Dystrophy (DMD).Objective: To evaluate testicular development and function in DMD over 12 months.Methods: All data are presented as median(range). 23 boys aged 12.4 years (10.0, 16.8) with a bone age delay of 0.9 years (−2.4, 7.1) had physical and biochemical assessment of puberty at Month 0(M0) and Month 12(M12) and divid...

ea0059p188 | Reproduction | SFEBES2018

The impact of testosterone level on body composition in men with type 2 diabetes (T2D)

Mumdzic Enis , Muraleedharan Vakkat , Kelly Daniel M , Kapoor Dheeraj , Jones Thomas Hugh

Sex hormones are important determinant of body composition. The significant negative correlation between testosterone and obesity, positive correlation between testosterone and muscle mass and that testosterone therapy increases muscle mass in hypogonadal men is well-known.Objectives: To assess the impact of total testosterone (TT) level on body composition in men with T2D.Methods: A cross-sectional study involving men with T2D (<e...

ea0059p189 | Reproduction | SFEBES2018

From Evidence to Practice, group education as part of routine outpatient clinic in Polycystic Ovary Syndrome a proof of concept intervention

Mani Hamidreza , Reddy Narendra , Bhake Ragini , Pierides Michael , Patel Kishor , Levy Miles

Background: The benefits of patient education in women with polycystic ovary syndrome (PCOS) are known but a cost effective way to offer the education to these patients need to be assessed. As part of a quality improvement project in an outpatient setting we tested the idea of incorporating group education for women with PCOS in their routine care process. We tested two different methods.Methods: 1. January-June 2017: Ad hoc open patient invitation<p...

ea0059p190 | Reproduction | SFEBES2018

Clomiphene citrate treatment in women with hypothalamic amenorrhea

Kurera Isuri , Yang Tian , Bano Gul

Functional hypothalamic amenorrhoea (FHA) is a disorder associated with functional inhibition of the hypothalamic-pituitary-ovarian axis due to deficiency of pulsatile GnRH. The incidence of FHA ranges from 15 to 48% of all secondary amenorrheas. The abnormal GnRH secretion leads to decreased pulses of gonadotropins, absent midcycle surges in luteinizing hormone (LH) secretion, absence of normal follicular development, anovulation, and low estradiol (E2). Causes of FHA can be ...

ea0059p191 | Reproduction | SFEBES2018

Reproductive function in women after kidney transplantation

Kudrytskaya Anastasia , Doronina Olga

According to population registries prevalence of chronic kidney disease (CKD) in the world is about 10%. Global trends show growth of CKD due to diabetic nephropathy, chronic tubulointerstitial nephritis, secondary nephropathies. Kidney transplantation is a ‘golden standard’ in CKD treatment. Is it performed about 100 times per year in The republican research and practice center for organ and tissue transplantation. The aim of the study was to evaluate menstrual func...

ea0059p192 | Reproduction | SFEBES2018

Alteration to PGF and IGF-1, signalled the adverse growth of the foetus and placenta in a genistein exposed pregnancy in experimental rats

Awobajo Funmileyi , Abdul Mariam , Aminu Balikisu , Medobi Ejike

The mechanism of the adverse influence of genistein; a soya phytoestrogen on foetal development is still poorly understood. Previous reports showed adverse effects on thyroid and leptin hormone, C-reactive protein and thyroxin kinase activities. This study evaluated the changes to the level of the insulin-like growth factor-I (IGF-1) and placenta growth factor (PGF) in rat pregnancy exposed to genistein. Pregnant rats grouped into 2 mg/kg and 4 mg/kg genistein treated groups w...

ea0059p193 | Reproduction | SFEBES2018

Anti-fertility effect of aqueous seed extract of Buchholzia Coriacea

Iranloye Bolanle , Ojikutu Moninuola

The leaves and seeds of Buchholzia coriacea (BC) are known to have antimalarial effect. Many antibiotic and antimalarial agents are known to have antifertility actions. This study was designed to investigate the effect of the aqueous seed extract of buccholzia coriacea on fertility parameters in female rats. Forty regularly cycling rats were randomly divided into two equal groups: BC-treated group (BCT group) received aqueous extract of the seed (200 mg/kg) and the co...

ea0059p194 | Reproduction | SFEBES2018

Investigating the roles of steroids in gonadal development and maintenance using an androgen and cortisol deficient zebrafish model

Oakes James , Li Nan , Wistow Belinda , Storbeck Karl-Heinz , Cunliffe Vincent , Krone Nils

Sex development in zebrafish is highly plastic, making this species an ideal model for investigation of endocrine disruption and gonadal development and function. However, the hormonal regulation of these processes in zebrafish is poorly understood. We have used a model of androgen and glucocorticoid deficiency to explore these processes. In humans, ferredoxin (FDX1) is an electron-providing cofactor required for steroid biosynthesis. The zebrafish homologue of FDX1, ...

ea0059p195 | Reproduction | SFEBES2018

Exhaustive characterization of placental production of progesterone in vitro

Fraichard Camille , Hebert-Schuster Marylise , Garnier Anthony , Sibiude Jeanne , Bouzerara Amina , Fournier Thierry , Trabado Severine , Guibourdenche Jean

Placenta is an endocrine organ, secreting steroids (progesterone [P4], estrogens) and hCG, thanks to villous tissu (cytotrophoblasts [VCT] and syncytiotrophoblast [ST]). P4 is required for implantation and maintenance of pregnancy. P4 is synthetized from maternal cholesterol thanks to mitochondrial transporter MLN64 and P450SCC and HSD3B1 enzymes. We aimed to characterize P4 production in human placenta during VCTs differentiation into ST in vitro. VCTs isolated from ...

ea0059p196 | Reproduction | SFEBES2018

Alterations in some heavy metal levels correlated with cellular adenosine triphosphate production in male rats exposed to a municipal dumpsite

Oyelowo Oluwakemi , Oju Omamogho , Mofolorunso Adekunle

Heavy metals are present in different waste types and products found in landfills and they are known not only to pose considerable health risk in the waste management sector but also specifically engender health hazards for the environment and people living near the landfills and dumpsites. However, there is little evidence associating male proximity to dumpsites with reproductive function. This study was carried out to examine the effects of heavy metal levels on reproductive...

ea0059p197 | Reproduction | SFEBES2018

Reproductive Life Course Project: Preliminary data from UK Turner Syndrome Pregnancy audit

Burt Elizabeth , Pimblett Antoinette Cameron , Donohoe Mollie , Calanchini Matilde , Morton Claire , Smyth Arlene , Brooke Antoinia , Gleeson Helena , Simpson Helen , Turner Helen E , Davies Melanie C , Conway Gerard S

Turner Syndrome (TS) affects 1:2500 females and is caused by the partial or complete loss of one X chromosome. About 80% of women with TS experience primary amenorrhea and therefore the only option for fertility treatment is ovum donation (OD). The remaining 20% may have the opportunity for a spontaneous pregnancy. Pregnancy in women with TS has been associated with excess obstetric risk such as miscarriage and hypertension. Maternal mortality has been estimated to be 2% risk ...

ea0059p198 | Reproduction | SFEBES2018

Dax1 controls female fertility as a hypothalamic rheostat of estrogen receptor-alpha

Fernandes Freitas Isabel , Manchishi Stephen , Colledge William , Dhillo Waljit , Owen Bryn

Coupling the release of pituitary hormones to the developmental stage of the oocyte is essential for female fertility. It requires estrogen to have simultaneous positive and negative feedback effects on spatially-distinct regions of the hypothalamus. However, the mechanistic basis for this differential effect is not known. We have found that negative-feedback is mediated by the nuclear receptor Dax1, which is present in the arcuate hypothalamic nucleus and serves as a ligand-d...

ea0059p199 | Reproduction | SFEBES2018

Recombinant FSH dosing during controlled ovarian stimulation in IVF treatment

Patel Aaran , Abbara Ali , Chia Germaine , Eng Pei , Phylactou Maria , Clarke Sophie , Comninos Alexander , Trew Geoffrey , Kelsey Tom , Salim Rehan , Dhillo Waljit

Background: During IVF treatment, a pharmacological dose of recombinant FSH (rFSH) is used to induce multi-follicular growth (controlled ovarian stimulation; COS). An insufficient dose of rFSH negatively impacts the number of oocytes retrieved, whereas an excessive dose risks the potentially life-threatening complication ‘ovarian hyperstimulation syndrome’. Hence, appropriate rFSH dosing is regarded as a key treatment decision affecting both the success and safety of...