Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep713 | Male Reproduction | ECE2016

An audit on evaluation and management of men with hypogonadotrophic hypogonadism in a district general hospital in South-Wales

Hamdan Khaliq , Davies Stephen , Kalhan Atul

Introduction: The current Endocrine Society guidelines (2010) recommend biochemical and radiological evaluation of men with HH to ascertain underlying hypothalamic and/or pituitary aetiology although the cost-effectiveness of this strategy is yet to be established. We did a retrospective audit to ascertain epidemiology, management and diagnostic outcomes for men with HH in our hospital practice against the current Endocrine society guidelines.Methods: A ...

ea0065p336 | Nursing practice | SFEBES2019

Effectiveness of a nurse-led adrenal incidentaloma (AI) clinic at the University Hospital of Wales, Cardiff

Lewis Janet , Hamdan Khaliq , Scholz Anna , Lansdown Andrew

Background: In December 2017, a Nurse-Led AI clinic was introduced at University Hospital of Wales, Cardiff for the evaluation and follow-up of these patients. The clinic pathway was based upon the 2016 European Society for Endocrinology (ESE) guidelines on the management of adrenal incidentalomas.Aim: To evaluate the effectiveness of this new service and the cost-saving benefit.Methods: Electronic and paper-based patient records w...

ea0044ep75 | (1) | SFEBES2016

The challenges to diagnose and differentiate TSHoma from thyroid hormone resistance: a case report

Hamdan Khaliq , Koulouri Olympia , Gurnell Mark , Chatterjee Krishna , Owen Penelope

TSHoma is rare, with an incidence of 1 per million, and <1% of all pituitary tumours. We reported a case involving a 49-year-old female who was first referred to our endocrine unit in 2006 with excessive lethargy and abnormal TFT’s. She was thought to have thyroid hormone resistance for several years until 2015 when she reported having persistent symptoms and further investigation suggested an alternative diagnosis.Results: Ft4=41.6 pmol/l, TSH=...

ea0038p63 | Clinical practice/governance and case reports | SFEBES2015

A case to remember

Rahman Mohammad , Obuobie Kofi , Hickin Tom , Hamdan Khaliq

Introduction: X-linked adrenoleucodystrophy (XALD) is a progressive disorder affecting adrenal glands, testis, and myelin stability, that normally caused by mutations in ABCD1 (NM_000033) gene There is a failure of β-oxidation of fatty acids within peroxisomes due to reduced activity of very long chain acyl-CoA synthetase and can be diagnosed by the demonstration of elevated very long chain fatty acid.Case report: We report a case of a 32-y...

ea0038p457 | Thyroid | SFEBES2015

R438H missense mutation related generalised resistance to thyroid hormone (GRTH): a case series report in three generations

Bashir Jawad , Saeed Tamar , Hamdan Khaliq , Bashir Hadeel , Khan Irfan

: A family with generalised resistance to thyroid hormone secondary to a missense point mutation in thyroid hormone receptor β (TR-β) gene corresponding to substitution of arginine to histidine at amino acid 438 (R438H) is described in three successive generations.Case 1: (Index case) A 43 year old lady presented with thyrotoxicosis and was initially treated with carbimazole followed by radio-iodine ablation of the thyroid. Thyroxine was commen...

ea0038p465 | Thyroid | SFEBES2015

The value of thyroxine absorption test followed by weekly thyroxine administration in determining the cause of persistent hypothyroidism despite high dose L-thyroxine treatment: a case report

Hamdan Khaliq , Rahman Mohammad , Mohan-Babu Priya , Obuobie Kofi

Objective: Most hypothyroid patients require an optimal dose of 1.6–1.8 μg/body weight (kg) of L-thyroxine to restore a normal TSH. Poor response to treatment can be due to malabsorption, drugs interaction and poor compliance. We conducted a test to determine the likely cause of persistent hypothyroidism in a coeliac patient despite taking supraphysiological doses of L-thyroxine (>1000 μg OD).Case...

ea0094p336 | Endocrine Cancer and Late Effects | SFEBES2023

Ectopic ACTH-dependant Cushing’s syndrome in MEN2A and metastatic medullary thyroid carcinoma: Challenges beyond Diagnosis

Bahl Suhani , Khaliq Hamdan Mohd , Smeeton Fiona , MacLean Jillian

Introduction: Multiple endocrine neoplasia, type 2A (MEN 2A) is a hereditary syndrome characterized by medullary carcinoma of the thyroid, pheochromocytoma, parathyroid hyperplasia or adenomas due to mutation in RET oncogene on chromosome 10. Complications can occur as a result of ectopic ACTH causing Cushings syndrome. We present here a case initially presenting to hospital with worsening shortness of breath on a background of metastatic medullary thyroid can...

ea0094p251 | Neuroendocrinology and Pituitary | SFEBES2023

Severe arginine vasopressin resistance (nephrogenic diabetes insipidus) secondary to lithium requiring intensive care admission

Keen Fred , Hamdan Khaliq , Beckett Samuel , Smeeton Fiona

Arginine vasopressin resistance (AVP-R) (previously termed nephrogenic diabetes insipidus) is well known to be associated with lithium treatment. However, cases are usually mild and patients can almost always compensate for their polyuria with excessive fluid intake. We present the case of a moribund patient who required intensive care admission secondary to AVP-R, developing hypernatraemia to 183mmol/l and serum osmolality of 394mmol/kg. A 68 year old gentleman, on lithium tr...

ea0038p39 | Clinical biochemistry | SFEBES2015

Are we doing to many short synecthan test

Rahman Mohammad , Obuobie Kofi , Okosieme Onyebuchi , Farhan Nadia El , Hamdan Khaliq

Background: The short Synacthen test (SST) is frequently used to diagnose adrenal insufficiency; however the role of baseline cortisol. With the recent European shortage of synacthen, there was a pressing need to identify the best possible way to use the resource and rationalize the test. Our aim is to identify whether baseline cortisol can be safely used to rule out adrenal insufficiency in clinical practice.Methods: All SSTs performed at the OPD, Royal...

ea0034p90 | Clinical practice/governance and case reports | SFEBES2014

Teriparatide infusion for post-thyroidectomy hypocalcaemia: a case report

Hamdan Khaliq , Bashir Jawad , Khan Ishrat , Okosieme Onyebuchi , Agarwal Neera , Aldridge Andrew

Hypoparathyroidism post-thyroidectomy is a recognised complication and treated with calcium supplements, vitamin D, and rather recently with recombinant human parathyroid hormone therapy (teriparatide). We report a case of a 68-year-old female who developed refractory hypocalcaemia and hypomagnesaemia following thyroidectomy for a multinodular goitre. Her management was complicated by inflammatory bowel disease, surgically treated with an ileostomy in situ. Post-opera...