ea0014p145 | (1) | ECE2007
Fassnacht Martin
, Hahner Stefanie
, Heinrich Barbara
, Adam Patrick
, Johanssen Sarah
, Quinkler Marcus
, Koschker Ann-Cathrin
, Stroebel Philipp
, Marx Alexander
, Allolio Bruno
Objectives: Adrenocortical carcinoma (ACC) is a rare malignancy with incompletely understood pathogenesis and poor prognosis. Overexpression of epidermal growth factor receptor (EGFR) has been demonstrated in several tumors and is partly associated with a more aggressive phenotype and a worse prognosis. In addition, targeting the EGFR tyrosine kinase represents a successful new therapeutic strategy, e.g. in non-small cell lung cancer. Therefore, we investigated the role of EGF...