Searchable abstracts of presentations at key conferences in endocrinology

ea0029p997 | Growth hormone IGF axis - basic | ICEECE2012

Factors affecting IGF1 response to GH during transition

Thankamony A. , Capalbo D. , Heywood J. , Williams R. , Ong K. , Dunger D. , Simpson H.

Background: GH replacement during the childhood-adult transition period is important for somatic maturation. The aim of the study was to explore the factors influencing IGF1 response to GH during transition.Methods: KIMS (Pfizer International Metabolic Study) database in UK was interrogated, and 98 patients (55 male, median age 20.7 years (15.7–25.8)) with childhood-onset GH deficiency (Co-GHD), who were started on adult dose of GH during transition...

ea0024p37 | (1) | BSPED2010

Type 2 diabetes in childhood: building a platform for interventions to prevent the progression to cardiovascular disease

Barnett A , Barrett T , Cotter C , Dunger D , Fulton E , Heywood J , Ilsley E , O'Brien A , Shield J , Wales J

Type 2 diabetes (T2DM) is increasing in children in the UK and worldwide, most likely related to the rising prevalence of obesity. We are developing a UK national cohort of children (under 18 completed years) with diabetes defined by WHO criteria, suspected type 2, BMI above 85th centile; but who do not have genetically confirmed monogenic diabetes, secondary diabetes, or any evidence of pancreatic autoimmunity. The aim of this study is to describe the characteristics of the f...