Endocrine Abstracts

Body composition is a major determinant of fitness and health. Many of the problems of aging are caused by detrimental changes in body composition. Hormones play a central role in the regulation of body composition. Our laboratory has been investigating the metabolic and molecular mechanisms of GH action and its interaction with sex steroids in the regulation body composition in adult human. The liver is an important site of physiological interaction as it is a sex steroid res...

Lipid metabolism diseases are continuously increasing due to lifestyle changes, and many studies have reported that the incidence of other cancers increases in these diseases. Thyroid cancer occurs frequently, and its prognosis is good; therefore, there are many survivors. In this study, we aimed to confirm whether thyroid cancer itself affects the risk of secondary cancer in patients with lipid metabolic disease and the factors affecting this risk through analysis of institut...

Evaluating patients with adrenal disease is uniquely challenging as biochemical parameters for assessing disease control or adequacy of hormone replacement are imprecise or lacking. QOL measures are increasingly being used to assess patients with adrenal disease, using a range of generic and disease specific measures. Reduced quality of life has been observed in patients with adrenal disease, even when biochemical cure is possible. We performed a sys...

Evaluating patients with adrenal disease is uniquely challenging as biochemical parameters for assessing disease control or adequacy of hormone replacement are imprecise or lacking. QOL measures are increasingly being used to assess patients with adrenal disease, using a range of generic and disease specific measures. Reduced quality of life has been observed in patients with adrenal disease, even when biochemical cure is possible. We performed a sys...

Ken K Y Ho, University of New South Wales, Sydney, Australia AbstractKen Ho is a professor of Medicine at the University of New South Wales and is the Head, Pituitary Research Unit, Garvan Institute of Medical Research and Chairman, Department of Endocrinology, St. Vincent's Hospital, Sydney.He graduated in medicine at the University of Sydney in 1975, undertook research studies towards a Doctora...

We present the case of a 19-year old male who presented with a generalized tonic clonic seizure associated with visual loss. Examination revealed severe visual field defects and arrested pubertal development. Laboratory evaluation revealed a very elevated prolactin of 298 410 mU/l, hypogonadotrophic hypogonadism, secondary adrenal insufficiency, and secondary hypothyroidism. He was also found to have thrombocytosis due to JAK 2 essential thrombocythaemia. Pituitary MRI reveale...

We present the case of a 19-year old male who presented with a generalized tonic clonic seizure associated with visual loss. Examination revealed severe visual field defects and arrested pubertal development. Laboratory evaluation revealed a very elevated prolactin of 298 410 mU/l, hypogonadotrophic hypogonadism, secondary adrenal insufficiency, and secondary hypothyroidism. He was also found to have thrombocytosis due to JAK 2 essential thrombocythaemia. Pituitary MRI reveale...

Introduction: Diabetic Ketoacidosis (DKA) is a potentially life threatening complication of type-1 diabetes mellitus (T1DM) in children and young people (CYP). An Integrated Care Pathway (ICP) for management of DKA is based on the current British Society for Paediatric Endocrinology and Diabetes (BSPED) guidelines. The BSPED guideline moved away from cautious fluid replacement toward a liberal approach for resuscitation and maintenance fluids based on current evidence. The ICP...

Background: Targeted therapy using phosphatidylinositol 3-kinase (PI3K) inhibitors has become widespread in the treatment of cancers. Although PI3K inhibitors raised concern about the alteration of glucose and lipid metabolism from animal studies, human clinical data have been rarely reported.Aim: We investigated the clinical manifestations, incidence of diabetes and its predictive factors in cancer patients who treated with PI3K inhibitors.<p class=...

Although the steroidogenesis in testis occur in a paracrine rather than in an endocrine, the comparative metabolic pathways between fetal and adult mice are not fully understood. Here, gas chromatography-mass spectrometry-based assay for profiling of 23 androgens, 7 estrogens, 13 corticoids, and 14 progestagens has been developed and applied to quantify their testis levels from both fetal and adult mice. Testis samples were purified with Oasis HLB solid-phase extraction and se...