Endocrine Abstracts

Body composition is a major determinant of fitness and health. Many of the problems of aging are caused by detrimental changes in body composition. Hormones play a central role in the regulation of body composition. Our laboratory has been investigating the metabolic and molecular mechanisms of GH action and its interaction with sex steroids in the regulation body composition in adult human. The liver is an important site of physiological interaction as it is a sex steroid res...

Lipid metabolism diseases are continuously increasing due to lifestyle changes, and many studies have reported that the incidence of other cancers increases in these diseases. Thyroid cancer occurs frequently, and its prognosis is good; therefore, there are many survivors. In this study, we aimed to confirm whether thyroid cancer itself affects the risk of secondary cancer in patients with lipid metabolic disease and the factors affecting this risk through analysis of institut...

Evaluating patients with adrenal disease is uniquely challenging as biochemical parameters for assessing disease control or adequacy of hormone replacement are imprecise or lacking. QOL measures are increasingly being used to assess patients with adrenal disease, using a range of generic and disease specific measures. Reduced quality of life has been observed in patients with adrenal disease, even when biochemical cure is possible. We performed a sys...

Evaluating patients with adrenal disease is uniquely challenging as biochemical parameters for assessing disease control or adequacy of hormone replacement are imprecise or lacking. QOL measures are increasingly being used to assess patients with adrenal disease, using a range of generic and disease specific measures. Reduced quality of life has been observed in patients with adrenal disease, even when biochemical cure is possible. We performed a sys...

Ken K Y Ho, University of New South Wales, Sydney, Australia AbstractKen Ho is a professor of Medicine at the University of New South Wales and is the Head, Pituitary Research Unit, Garvan Institute of Medical Research and Chairman, Department of Endocrinology, St. Vincent's Hospital, Sydney.He graduated in medicine at the University of Sydney in 1975, undertook research studies towards a Doctora...

A 35-year-old lady presented in Feb 2022 for lower limb weakness for 2 months, easy fall and amenorrhoea for 6 months. Her potassium was 2.4mmol/l. Clinically, she had moon face and proximal muscle weakness. Her workup showed metabolic alkalosis, renal loss of potassium and high 24-hour urine free cortisol (UFC) 825 nmol/l (24-140), which was 5.9x above the upper limit of normal (ULN). The paired baseline ACTH and morning cortisol were 22.1 and 469nmol/l respectively. 1mg ONDS...

Subcutaneous ossifications (SCO) represent a recognized manifestation of pseudohypoparathyroidism type 1A (PHP1A) and pseudopseudohypoparathyroidism (PPHP), posing significant morbidity to affected individuals. This report details the case of a 37-year-old woman with PHP1A with extensive scalp calcifications, an unusual and unexpected finding. The patient presented with multiple firm skin nodules on the right knee and dorsum of both hands. Having been diagnosed with hypothyroi...

We present the case of a 19-year old male who presented with a generalized tonic clonic seizure associated with visual loss. Examination revealed severe visual field defects and arrested pubertal development. Laboratory evaluation revealed a very elevated prolactin of 298 410 mU/l, hypogonadotrophic hypogonadism, secondary adrenal insufficiency, and secondary hypothyroidism. He was also found to have thrombocytosis due to JAK 2 essential thrombocythaemia. Pituitary MRI reveale...

We present the case of a 19-year old male who presented with a generalized tonic clonic seizure associated with visual loss. Examination revealed severe visual field defects and arrested pubertal development. Laboratory evaluation revealed a very elevated prolactin of 298 410 mU/l, hypogonadotrophic hypogonadism, secondary adrenal insufficiency, and secondary hypothyroidism. He was also found to have thrombocytosis due to JAK 2 essential thrombocythaemia. Pituitary MRI reveale...

Introduction: Diabetic Ketoacidosis (DKA) is a potentially life threatening complication of type-1 diabetes mellitus (T1DM) in children and young people (CYP). An Integrated Care Pathway (ICP) for management of DKA is based on the current British Society for Paediatric Endocrinology and Diabetes (BSPED) guidelines. The BSPED guideline moved away from cautious fluid replacement toward a liberal approach for resuscitation and maintenance fluids based on current evidence. The ICP...