Searchable abstracts of presentations at key conferences in endocrinology
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26th European Congress of Endocrinology

Stockholm, Sweden
11 May 2024 - 14 May 2024

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We are pleased to announce that ECE 2024 will be held in Stockholm, Sweden from 11-14 May 2024. We will, once again, be offering the hybrid format next year so you can join us in person in Sweden or remotely with ECE@Home.

Poster Presentations

Calcium and Bone

ea0099p33 | Calcium and Bone | ECE2024

Elevated serum uric acid in asymptomatic primary hyperparathyroidism: a biomarker of disease severity?

Malagrino Matteo , Bisceglia Nicolo , Vandi Giulia , Piazza Anna , Pagotto Uberto , Zavatta Guido

Context: Numerous studies propose a potential role of PTH in uric acid (UA) metabolism, particularly through its impact on the ABCG2 transporter, which is responsible for UA excretion in the intestines and kidneys. Another suggested mechanism involves increased tubular reabsorption of UA due to hypercalcemia-induced extracellular volume contraction. Elevated UA levels constitute a well-established risk factor for cardiovascular disease, nephrolithiasis, and chronic kidney dise...

ea0099p34 | Calcium and Bone | ECE2024

Extensive scalp calcification in pseudohypoparathyroidism type 1A: A case report and genetic insight

Kang Ho-Cheol , Kim HeeKyung

Subcutaneous ossifications (SCO) represent a recognized manifestation of pseudohypoparathyroidism type 1A (PHP1A) and pseudopseudohypoparathyroidism (PPHP), posing significant morbidity to affected individuals. This report details the case of a 37-year-old woman with PHP1A with extensive scalp calcifications, an unusual and unexpected finding. The patient presented with multiple firm skin nodules on the right knee and dorsum of both hands. Having been diagnosed with hypothyroi...

ea0099p35 | Calcium and Bone | ECE2024

Utility of 18F-choline PET-CT in the localization of adenomas in primary hyperparathyroidism

Silla Elena Martinez , Charneco Migueluesada , Sanchez Javier Garcia , Rodriguez Juarez Raul , Montoya Juan Luis Delgado , Lozano Pablo Jose Lopez-Ibarra

Objective: The definitive treatment of primary hyperparathyroidism (PPH) is the removal of the affected gland(s). However, its localization can be complicated. The usefulness of 18F-Choline PET-CT versus classical techniques is unknown. The aim of this study was to evaluate the results of 18F-Choline PET-CT in the detection of hyperfunctioning parathyroid tissue with respect to conventional imaging tests and to analyze the relationship between its findings and the levels of ca...

ea0099p36 | Calcium and Bone | ECE2024

Impact of parathyroidectomy on calcium metabolism, bone mineral density and trabecular bone score in patients with non-syndromic primary hyperparathyroidism

Kardalas Efstratios , Ntali Georgia , Mouxtouris Panagiotis , Papachristou Aglaia , Tzanela Marinella

Background/aim: Primary hyperparathyroidism (pHPT) is a relatively common endocrine disorder, which is associated with severe disruption of calcium metabolism and deterioration of bone density and quality. Our study aimed at examining the effect of parathyroidectomy on bone mineral density (BMD), T-Score in both the femoral neck (FN) and the lumbar spine (LS) and on trabecular bone score (TBS).Materials and methods: A cohort of 280 adult patients (195 ma...

ea0099p37 | Calcium and Bone | ECE2024

Intrathyroidal parathyroid adenoma: Two case reports

Andrei Anca Maria , Manole Andreea , Ungureanu Alicia , Varlan Delia , Dobre Ramona , Burcea Iulia , Poiana Catalina

Introduction: The basis of treatment of primary hyperparathyroidism (pHPT) is parathyroidectomy of the responsible lesion, and thus, preoperative localization is important. Ectopic parathyroid adenomas are rare, and they can be accounted for persistent or recurrent hyperparathyroidism. An intrathyroidal parathyroid adenoma (IPA) is an ectopic variant where the adenoma is either partly (>50%) or completely enveloped by the thyroid gland. The incidence of IPAs ranges from 0....

ea0099p38 | Calcium and Bone | ECE2024

Hypoparathyroidism following thyroid surgery: Risk factors and the role of early postsurgical PTH determination

Matos Tania , Dias Daniela , Silvestre Catarina , Serra Filipa , Marques Pedro , Leichsenring Carlos , Pinheiro Nuno , Sapinho Ines

Introduction: Hypoparathyroidism is one of the most common complications following thyroidectomy and it is associated with significant morbidity. It usually occurs within the first 48 h after thyroid surgery, however hypocalcemia symptoms may only begin up to 64 h after surgery. Therefore, early detection of hypoparathyroidism is essential to a secure postsurgery discharge.Objectives: We aimed to evaluate the potential risk factors for postsurgical hypop...

ea0099p39 | Calcium and Bone | ECE2024

Co-morbidities in adults with hereditary hypophosphatemia compared to controls – a retrospective Danish register study

Beck-Nielsen Signe , Johansen Ulla Ege , Hansen Rikke Faergemann , Gleisner Jennifer , Williams Angela

Background: Hereditary hypophosphatemia (HH) are rare diseases, characterized by excessive renal phosphate wasting and inappropriately low 1,25-dihydroxy-vitamin D causing hypophosphatemia. In children, the disease manifests as rickets and osteomalacia, in adults osteomalacia.Aim: The study aims to describe the co-morbidities more prevalent in adults (18y+) with HH and the median age at first diagnosis compared to controls.Methods:...

ea0099p40 | Calcium and Bone | ECE2024

Comparative effects of vitamin D supplementation on serum calciotropic hormone profile, in orthodox nuns with hypovitaminosis d in different regions of greece, versus intermittent fasting and western diet in lay women

Karras Spyridon , Georgopoulos Neoklis , Mouslech Zadalla , Koukoulis Georgios , Talidis Filotas , Pilz Stefan , Hewison Martin

Introduction: Greek Orthodox monasteries due to their sartorial habits, comprise a population with high prevalence of hypovitaminosis D. Intermittent religious fasting is adopted by this population, as well as from a large part of general lay Greek population. Comparative effects of vitamin D supplementation and intermittent fasting on vitamin D equilibrium and calciotropic profiles remain scarce.Aim: To comparatively evaluate effects of vitamin D supple...

ea0099p41 | Calcium and Bone | ECE2024

Frequency and causes of hypophosphatemia in internal medicine patients

Hubener Lisa , Haas Christian , Harbeck Birgit

Background: Hypophosphatemia is of relevant clinical importance, especially in its severe form. Hypophosphatemia occurs when serum phosphate levels are below 0.84 mmol/l. It can be divided into a mild form (serum phosphate between 0.5 and 0.83 mmol/l), a moderate form (serum phosphate between 0.3 and 0.5 mmol/l) and a severe form (serum phosphate <0.3 mmol/l). Approximately 2.2 to 3.1% of hospitalized patients not requiring intensive care are affected (Brunelli et al., 200...

ea0099p42 | Calcium and Bone | ECE2024

Unveiling unique clinical phenotypes of hip fracture patients and the temporal association with cardiovascular events in Hong Kong and the United Kingdom: A retrospective study

Cheung Ching-Lung , Hsu Warrington , Zhang Xiaowen , Sing Chor-Wing , Tan Kathryn , Wong Ian , Lau Wallis

Major adverse cardiac events (MACE) are the leading cause of death among hip fracture patients. This study aimed to: (1) identify hip fracture subphenotypes using LCA and (2) evaluate the prognosis of the hip fracture subphenotypes on CVE-related outcomes in two extensive hip fracture cohorts from Hong Kong (HK CDARS; n=78,417) and the United Kingdom (UK THIN; n=27,948), employing both the conventional cohort (between-individual comparison) design and the sel...

ea0099p43 | Calcium and Bone | ECE2024

The association between the ‘time to first fracture’ and imminent fracture risk – data from the FRISBEE cohort

de Filette Jeroen M.K. , Charles Alexia , Bellanger Amelie , Laura Iconaru , Baleanu Felicia , Surquin Murielle , Pierre Bergmann , Body Jean-Jacques

Background: Risk factors for fragility fractures were assessed in several prediction models (e.g. FRAX®, Garvan, FRISBEE, …). The predictors of a shorter ‘time to first fracture’ and its impact on imminent fracture risk, however, remain to be determined.Methods: The concept of ‘time to first fracture’ between inclusion in the FRISBEE cohort (‘Fracture RIsk Brussels Epidemiological Enquiry’; 3560 postmenopausal wom...

ea0099p44 | Calcium and Bone | ECE2024

Risk of sarcopenia can predict quality of life in Primary Hyperparathyroidism

Manani Christina , Tzikos Georgios , Papavramidis Theodosios S

Background: A specific self-administered health-related quality of life questionnaire for sarcopenia, the sarcopenia and Quality of life (SarQol®) has been recently developed. The questionnaire is composed of 55 items and organized into seven domains of quality of life. The Pasieka Quality of life questionnaire (PAS-Qol) is a specific self-administered quality of life questionnaire that has been developed for patients with primary hyperparathyroidism. The questionnaire ha...

ea0099p245 | Calcium and Bone | ECE2024

Education, and early retirement in patients with hereditary hypophosphatemia compared to controls – a retrospective Danish register study

Beck-Nielsen Signe , Johansen Ulla Ege , Hansen Rikke Faergemann , Gleisner Jennifer , Williams Angela

Background: Hereditary hypophosphatemia (HH) are rare diseases, characterized by excessive renal phosphate wasting and inappropriately low 1,25-dihydroxy-vitamin D causing hypophosphatemia. In children, the disease manifests as rickets and osteomalacia, in adults osteomalacia. Complications from the disease appear with increasing age, in adults characterized by pain, arthrosis, persisting deformities of long bones if not corrected during childhood causing compromised functions...

ea0099p246 | Calcium and Bone | ECE2024

A rare cause of bone pain: Fibrodysplasia ossificans progressiva

Ertuna Gokcen Nailer , Altay Feride Pınar , Gurbuz Fatih , Tam Abbas Ali , Ozdemir Didem , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

Introduction: Fibrodysplasia ossificans progressiva (FOP), also known as stone man disease, is a rare connective tissue disorder with a prevalence of 1 in 2 million. It is caused by a mutation in ACVR1 gene, usually sporadic and sometimes with autosomal dominant (AD) inheritance. These patients are normal at birth except for the short great toes and hallux valgus. Over time soft tissues such as ligaments, skeletal muscles or tendons ossify. Diaphragm, tongue, extraocular and c...

ea0099p247 | Calcium and Bone | ECE2024

More potent antiresorptive effect of denosumab versus zoledronate in osteoporotic postmenopausal women with primary hyperparathyroidism

Kozamernik Katarina Mlekus , Ležaić Luka , Hočevar Marko , Kocjan Tomaž

Introduction: Primary hyperparathyroidism (PHPT) is a state of increased bone turnover that can result in secondary osteoporosis. Antiresorptive treatment can be used to preserve bone mineral density (BMD). We compared the impact of zoledronate and denosumab on bone-related biochemical parameters.Methods: We analyzed interim data from our ongoing randomized trial on osteoporotic postmenopausal women with PHPT who are being treated with either zoledronate...

ea0099p248 | Calcium and Bone | ECE2024

Comparison of fractional excretion of calcium from different urine samples in the differentiation between primary hyperparathyroidism and familial hypocalciuric hypercalcemia

Koster Markus , Martin Siegenthaler , Stefan Bilz

Background: Calculation of the fractional excretion of calcium (FECa) from 24-hour (24h) urine collections is recommended to identify patients with suspected familial hypocalciuric hypercalcemia (FHH) during the work-up of primary hyperparathyroidism (pHPT). The current study was designed to test whether calculating the FECa or calcium-to-creatinin clearance obtained from 24h urine specimen can be substituted by results obtained from second morning or spontaneous void urine sa...

ea0099p249 | Calcium and Bone | ECE2024

Burosumab treatment for FGF23-related hypophoshatemia in an adult patient with severe fibrous dysplasia in McCune-Albright syndrome

Stelmachowska-Banaś Maria , Cylke-Falkowska Karolina , Zgliczyński Wojciech , Misiorowski Waldemar

Background: McCune Albright syndrome (MAS) is a rare mosaic genetic disorder affecting 1/100 000 to 1/1 000 000 of the population. It arises from a somatic gain-of-function mutation in GNAS gene. The clinical picture is complex and includes fibrous dysplasia (FD), café-au-lait spots, precocious puberty and other hyperactive endocrinopathies. The degree of FGF23 overproduction is correlated with FD severity, and frank hypophosphatemia occurs only in patients with extensive...

ea0099p250 | Calcium and Bone | ECE2024

Cystic parathyroid adenomas – a rare case of primary hyperparathyroidism: Two case reports

Veraguth Katja , Kolb Walter , Maas Ole , Bilz Stefan

Less than 0.5% of parathyroid lesions are cysts out of which only 10–20% are endocrine active. Depending on their localisation, the most frequent symptom of a parathyroid cyst (PC) is neck mass (41.7%) with possible compressive symptoms. Women are more frequently affected and tend to have hormone-inactive PCs. Men tend to have endocrine-active PCs. The best diagnostic approach is still under debate as PCs are relatively rare.Case report 1: A 68-year...

ea0099p251 | Calcium and Bone | ECE2024

Age-associated changes of fast-twitch skeletal muscle fibers in male rats

Filipović Branko , Šošić-Jurjević Branka , Trifunovć Svetlana , Ristic Natasa , Manojlović-Stojanoski Milica , Nestorović Nataša , Ajdžanović Vladimir

Aging process is accompanied by structural and functional changes in different organs including bone and muscle tissues. Between these tissues there is a mutual interaction mediated by endocrine factors such as the peptide hormone osteocalcin, produced by osteoblasts. Since the skeletal muscles is composed of two basic fiber types, slow-twitch (type I) and fast-twitch (type II), the aim of this study was to examine the age-related changes in rat fast-twitch skeletal muscle fib...

ea0099p252 | Calcium and Bone | ECE2024

Role of variants of uncertain significance in determining bone fragility or low bone mineral density in adults: A multicenter study

Carrara Silvia , Vai Silvia , Mihalich Alessandra , Blasio Anna Di , Ponti Emanuela , Guabello Gregorio , Guarnieri Vito , Pigni Stella , Lania Andrea , Mazziotti Gherardo , Corbetta Sabrina

Osteoporosis causes bone fragility usually affecting the elderly. Genetic susceptibility plays a crucial role in determining the risk of fragility fractures and is involved in early-onset osteoporosis. When fragility fractures or low bone mineral density (BMD) occur in young adults without evident secondary osteoporosis, an underlying monogenetic bone disease should be assessed. The list of genes related to low BMD and their mutations is increasing. Nevertheless, little is kno...

ea0099p253 | Calcium and Bone | ECE2024

Alterations in phosphate metabolism in patients with Klinefelter’s syndrome

Indirli Rita , Lanzi Valeria , Petria Iulia , Mantovani Giovanna , Ferrante Emanuele

Background: Patients with Klinefelter’s syndrome (KS) present a high prevalence of osteopenia, osteoporosis and fragility fractures. Several factors may contribute to skeletal fragility, e.g. hypogonadism, derangements in vitamin D metabolism, reduced testicular secretion of Insulin-like Factor 3. However, phosphate metabolism has never been investigated.Methods: A retrospective analysis was conducted to investigate prevalence and characteristics of...

ea0099p254 | Calcium and Bone | ECE2024

Hypocalcemia after hyperthyroidism surgical treatment: Besides iatrogenic hypoparathyroidism

Rocha Jose Vicente , Vaz Lopes Marta , de Severino Mariana , Peixe Carolina , Gomes Ana , Alexandre Maria Ines , Bugalho Maria Joao

Introduction: Hypocalcemia is a possible complication of thyroid surgery, usually assumed in the context of iatrogenic hypoparathyroidism. On the other hand, Hungry Bone Syndrome (HBS) is a complication classically described after surgical correction of primary hyperparathyroidism. It is characterized by hypocalcemia with normal or elevated PTH values (usually accompanied by hypophosphatemia and hypomagnesemia) and occurs consequently to a compensatory bone formation after a p...

ea0099p255 | Calcium and Bone | ECE2024

Evaluating novel bone biomarkers (FGF2, lipocalin, sclerostin) in patients with tumor induced osteomalacia (TIO) and acromegaly

Gronskaia Sofia , Zuraeva Zamira , Nikankina Larisa , Belaya Zhanna

Background: Bone tissue is a non-classical endocrine organ, which controls phosphate metabolism through production of fibroblast growth factor 23 (FGF-23) mainly by osteocytes. Recent studies have demonstrated that specific proteins involved in paracrine regulation of bone remodeling can be measured in serum samples and may be involved in human metabolism.Aims: To evaluate serum biomarkers related to endocrine and paracrine function of bone tissue in pat...

ea0099p256 | Calcium and Bone | ECE2024

The association of vasomotor symptoms with fracture risk and bone mineral density in postmenopausal women: a systematic review and meta-analysis of observational studies

Anagnostis Panagiotis , Lallas Konstantinos , Pappa Anna , Avgeris Georgios , Beta Kristina , Damakis Dimitrios , Fountoukidou Eirini , Zidrou Maria , Lambrinoudaki Irene , Goulis Dimitrios

Purpose: Vasomotor symptoms (VMS) adversely affect postmenopausal quality of life. However, their impact on bone health has not been elucidated. This study aimed to systematically review and meta-analyze the evidence regarding the association of VMS with fracture risk and bone mineral density (BMD) in peri- and postmenopausal women.Methods: A literature search was conducted in PubMed, Scopus and Cochrane databases until 31 August 2023. Fracture, low BMD ...

ea0099p443 | Calcium and Bone | ECE2024

22q11.2 deletion syndrome diagnosed in the context of seizure and hypocalcemia in adulthood

Galani Maria , Effraimidis Grigoris , Gkountios Ioannis , Georgiou Eleni , Sakali Anastasia-Konstantina , Pappa Dimitra , Barmpa Eleftheria , Adamopoulos Nektarios , Bargiota Alexandra

Introduction: The 22q11.2 deletion syndrome (22q11.2DS) caused by a microdeletion of the 22q11.2 region of chromosome 22 is the most common deletion in humans causing a variety of disorders, including DiGeorge syndrome (OMIM #188400), velocardiofacial syndrome (OMIM #192430) and distal chromosome 22q11.2 deletion syndrome (OMIM #611867). Most individuals diagnosed with this condition are identified in early childhood and the diagnosis in adults is uncommon. It is characterized...

ea0099p444 | Calcium and Bone | ECE2024

Hyperostosis frontalis interna – a case of Morgagni–Stewart–Morel syndrome

Radulescu Vlad , Stanescu Anastasia , Stancu Cristina , Badiu Corin

Introduction: Morgagni–Stewart–Morel syndrome is defined as the absolute presence of hyperostosis frontalis interna, associated with metabolic, endocrine, and neuropsychiatric disorders. There are very few cases reported in the literature and some experts do not even recognize it but the exact etiology of the syndrome remains unclear; some theories relate to estrogen dysfunction, obesity and leptin dysfunction, and genetic alterations....

ea0099p445 | Calcium and Bone | ECE2024

Clinical characterization of a cohort of patients with multiple endocrine neoplasia syndrome type 1 (MEN1): role of the MEN1 gene mutation on the phenotypic expression of the syndrome

Pierotti Laura , Pardi Elena , Sardella Chiara , Valentina Simone/////Della , Lago Anna Dal , Piaggi Paolo , Bogazzi Fausto , Caligo Maria Adelaide , Cetani Filomena

The clinical diagnosis of MEN1 is established when a proband manifests at least two of the manifestations of the triad (Primary Hyperparathyroidism (PHPT), Pituitary adenoma, Gastroenteropancreatic Neuroendocrine Tumor (GEP-NET)). Typically, it is a familial disease (F-MEN1), while in about 10% of cases the disease is sporadic. In sporadic forms (S-MEN1), up to 70% of patients may exhibit a negative genetic analysis (MEN1-negative). These patients seem to have distinc...

ea0099p446 | Calcium and Bone | ECE2024

Investigating the etiology of non-surgical hypoparathyroidism: insights from a sponsored genetic testing program

Mannstadt Michael , Marelli Claudio , Sridhar Ananth , Smith Lyndsay , Roberts Mary Scott , Adler Scott , Mathew Arun

Hypoparathyroidism is a rare endocrine disorder characterized by inadequate production of parathyroid hormone to maintain normal blood calcium levels. Hypoparathyroidism is most frequently caused by damage to or removal of the parathyroid glands but can also be associated with genetic etiologies. Genetic forms of hypoparathyroidism can present as isolated or as part of a syndrome and include disorders of parathyroid gland formation, parathyroid hormone secretion, and damage to...

ea0099p447 | Calcium and Bone | ECE2024

Optimal strategies for vitamin D supplementation in the management of severe vitamin D deficiency

Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Mohamed Shayma

Introduction: The uncertainty surrounding the optimal dose to rectify severe vitamin D deficiency (VDD) necessitates further investigation.Aim: To review and analyze various vitamin D (VD) supplementation doses, durations, and their effects on 25-hydroxyvitamin D (25OHD) levels, along with their biochemical and clinical outcomes, in the management of VDD.Methods: We reviewed intervention studies targeting VDD from databases (PubMed...

ea0099p448 | Calcium and Bone | ECE2024

Formation of new bone lesions in an adult patient with fibrous dysplasia/McCune–Albright syndrome over 19 years and the effect of postoperative hypoparathyroidism on bone turnover markers – case report

Zajickova Katerina , Vcelak Josef

Introduction: Fibrous dysplasia (FD) is a rare mosaic disorder originating from the activating mutation in the gene encoding the alpha subunit of the Gs stimulatory protein (GNAS) in multipotent skeletal stem cells that cannot differentiate into bone-forming osteoblasts. FD is thought to be a self-limited disease with a peak of activity in childhood and a waning of activity in adulthood.Case presentation: We report a 39-year-old woman with mild ...

ea0099p449 | Calcium and Bone | ECE2024

The incidence of fractures in cancer patients initiating immune check-point inhibitors

Karov Ruth , Feigin Eugene , Osher Etty , Greenman Yona , Rouach Vanessa

Introduction: Immune check-point inhibitors (ICI) can cause adverse events in many organs due to the activation of T-cells. Data on the effect of ICI on bones and incidence of fracture is still scarce.Aim: To quantify the rate of osteoporotic fracture before and after the use of ICI in cancer patients.Methods: We retrospectively retrieved pertinent data of all patients who were treated with ICI between 2015 and 2023 at the Tel-Aviv...

ea0099p450 | Calcium and Bone | ECE2024

A pharmacoeconomic analysis from Italian guidelines for the management of sporadic primary hyperparathyroidism

Attanasio Roberto Samperi Irene , Scoppola Alessandro , Paoletta Agostino , Novizio Roberto , Vescini Fabio , Borretta Giorgio , Chiodini Iacopo , Papini Enrico , Persichetti Agnese , Basile Michele , Boniardi Marco , Carotti Marina , Castellano Elena , Cipriani Cristiana , Eller-Vainicher Cristina , Giannini Sandro , Iacobone Maurizio , Salcuni Antonio/////Stefano , Saponaro Federica , Spiezia Stefano , Versari Annibale , Zavatta Guido , Mitrova Zuzana , Giovannazzi Alexia , Saulle Rosella , Vecchi Simona , Antonini Debora , Calo Giorgio , Cetani Filomena , Cianferotti Luisella , Corbetta Sabrina , De Rimini Maria Luisa , Falchetti Alberto , Iannetti Giovanni , Laureti Stefano , Lombardi Celestino/////Pio , Madeo Bruno , Marcocci Claudio , Mazzaferro Sandro , Miele Vittorio , Minisola Salvatore , Palermo Andrea , Pepe Jessica , Tonzar Laura , Scillitani Alfredo , Grimaldi Franco , Cozzi Renato , Attanasio Roberto

Background: Primary hyperparathyroidism (PHPT) is the third most common endocrine disease and the most frequent cause of hypercalcemia in outpatients with an estimated incidence of 20/100 000/year and prevalence in the general population of 0.1%–0.4%. Parathyroidectomy (PTX) is the only treatment that can achieve PHPT cure but a few medications can be used to control calcium levels, bone and kidney impairment.Aims: 1) To assess costs associated with...

ea0099p451 | Calcium and Bone | ECE2024

Bone responsiveness in PTH resistance syndromes: preliminary data of a single centre retrospective study

Del Sindaco Giulia , Pagnano Angela , Cremaschi Arianna , Mantovani Giovanna

Inactivating PTH/PTHrP signaling disorders (iPPSDs, historically named pseudohypoparathyroidism (PHP)) are primarily characterized by end-organ resistance to parathormone (PTH), which leads to hypocalcemia, hyperphosphatemia and elevated PTH levels. The extent to which bone is responsive to PTH in these patients remains controversial. Until now, variable bone phenotypes have been associated to different subtypes of iPPSDs and increased concentrations of bone turnover markers (...

ea0099p452 | Calcium and Bone | ECE2024

Clustering of clinical and biochemical data for defining primary hyperparathyroidism ‘phenotypes’ and predicting parathyroid imaging results

Kucharczyk Karolina , Drynda Anna , Podlewski Jacek , Trofimiuk-Muldner Malgorzata , Hubalewska-Dydejczyk Alicja

Introduction: Primary hyperparathyroidism (PHPT) is a prevalent endocrinopathy typically identified through biochemical testing. PHPT is characterized by hypercalcemia accompanied by increased or inappropriately normal plasma parathyroid hormone (PTH) concentrations. Preoperative imaging is conducted when surgery is indicated to pinpoint parathyroid adenomas. MIBI scintigraphy is highly specific and sensitive in diagnosing PHPT, with a higher adenoma detection rate demonstrate...

ea0099p453 | Calcium and Bone | ECE2024

Mild hyponatremia is not associated with degradation of trabecular bone microarchitecture despite bone mass loss

Bioletto Fabio , Sibilla Michela , Berton Alessandro Maria , Prencipe Nunzia , Varaldo Emanuele , Maiorino Federica , Cuboni Daniela , Pusterla Alessia , Gasco Valentina , Grottoli Silvia , Ghigo Ezio , Arvat Emanuela , Procopio Massimo , Barale Marco

Context: Hyponatremia is associated with an increased risk of osteoporosis and fractures, and in recent years increasing evidence is accumulating in favor of a likely causal relationship between hyponatremia and bone loss. In rat models, the induction of hyponatremia enhances osteoclast activation and bone catabolism. In humans, the correction of hyponatremia by tolvaptan or SGLT2-inhibitors has a favorable effect on bone turnover markers, possibly due to an interplay both wit...

ea0099p454 | Calcium and Bone | ECE2024

The clinical presentation of primary hyperparathyroidism: effects of obesity and vitamin D deficiency

Zikan Vit , Hrdlicka Jan , Klimova Judita , Hana Jr Vaclav , Wagnerova Monika , Libansky Petr , Michalska Dana , Vlasakova Renata , Raska Jr Ivan

Our understanding of modifiable risk factors for developing primary hyperparathyroidism (PHPT) may support interventions to prevent the development of the disease or reduce its severity and deepen our insights into its pathogenesis. Obesity has been associated with elevated serum parathyroid hormone (PTH) in the general population and may also alter the clinical presentation in patients with PHPT.Objectives: The objectives of the study were to compare th...