Endocrine Abstracts

Body composition is a major determinant of fitness and health. Many of the problems of aging are caused by detrimental changes in body composition. Hormones play a central role in the regulation of body composition. Our laboratory has been investigating the metabolic and molecular mechanisms of GH action and its interaction with sex steroids in the regulation body composition in adult human. The liver is an important site of physiological interaction as it is a sex steroid res...

Ken K Y Ho, University of New South Wales, Sydney, Australia AbstractKen Ho is a professor of Medicine at the University of New South Wales and is the Head, Pituitary Research Unit, Garvan Institute of Medical Research and Chairman, Department of Endocrinology, St. Vincent's Hospital, Sydney.He graduated in medicine at the University of Sydney in 1975, undertook research studies towards a Doctora...

Patients with adult onset GHD (AO-GHD) manifest features of the metabolic syndrome (MetS) (abdominal obesity, dyslipidemia and insulin resistance), a condition associated with increased risk of diabetes mellitus (DM).We assessed metabolic status before and after 2 years of GH treatment and the occurrence of de novo DM in 712 patients with AO-GHD from HypoCCS drawn from the US (32.2%) and Europe (67.8%). Patients were divided into four BMI categori...

Somapacitan is a once-weekly, long-acting growth hormone (GH) derivative approved for the treatment of adult GH deficiency (AGHD). Our objective was to evaluate the effects of somapacitan on glucose metabolism compared with daily GH or placebo in patients with AGHD using data from three previously published phase 3 trials: REAL 1 (NCT02229851), REAL 2 (NCT02382939) and REAL Japan (NCT03075644). REAL 1 was a randomised, placebo-controlled (double-blind) and active-controlled (o...

Introduction: Growth hormone (GH) replacement therapy is safe and confers significant benefits in body composition, bone health, cardiometabolic risk factors, and quality of life in adults with GH deficiency. However, longer term safety and efficacy data are limited by the lack of consistency in data collection between studies. The study aim was to develop a simple global register by standardising and developing a minimum data set (MDS) to facilitate international collection o...