ea0029oc12.2 | Obesity Clinical | ICEECE2012
Arafat A.
, Homssi S.v.G.
, Weickert M.
, Kraatz J.
, Spranger J.
, Frystyk J.
, Pfeiffer A.
, Mohlig M.
Objectives: Insulin interacts with the GH insulin-like growth factor (IGF) system by a reciprocal regulation of IGF-binding proteins (IGFBPs) and GH, which in turn interact to regulate insulin sensitivity (IS). We previously showed that IGFBP-2 is involved in the insulin-induced reduction in IGF1 bioactivity. We here address the modulation of IGF1 bioactivity during acute lipid-induced insulin resistance.Methods: 18 healthy men (30.8±2.6 year...