Searchable abstracts of presentations at key conferences in endocrinology

ea0077op6.4 | Endocrine Cancer and Late Effects | SFEBES2021

Virtual Blood Pressure Monitoring in the Pre-operative Management of Phaeochromocytoma Patients in a Tertiary Centre during the COVID-19 Pandemic

Mile Rebecca , Bi Yixi , Gulamhusein Aziz , Hoong Ho Jan , Adam Safwaan

The usual management at our centre for patients awaiting phaeochromocytoma surgery involves pre-operative titration of alpha blockade with frequent clinic visits for blood pressure (BP) and heart rate (HR) monitoring. The COVID-19 pandemic restricted our ability to consult with patients frequently. To reduce infection risk, we incorporated virtual BP monitoring using a Microsoft Excel template coupled with regular remote consultations. We present a clinical case highlighting o...

ea0094p302 | Endocrine Cancer and Late Effects | SFEBES2023

Thyroid function in patients receiving immune checkpoint inhibitors: a large real-world cohort study

Kennedy Oliver , Hoong Ho Jan , Monaghan Phillip , Lorigan Paul , Adam Safwaan

Objective: This study aimed to characterise the relationship between immune checkpoint inhibitors (ICIs), which are commonly used to treat cancer, and thyroid dysfunction in terms of the proportions affected, timing of onset, sequalae and risk factors.Design: Retrospective cohort studyMethods: Patients with normal baseline thyroid function who received an ICI were included. Proport...

ea0094p93 | Neuroendocrinology and Pituitary | SFEBES2023

The clinical course of pituitary metastases: illustrations from clinical cases

Shaikh Sheeba , Iqbal Zohaib , Garcez kate , Waddell Tom , Hoong Ho Jan , Adam Safwaan

Pituitary metastases are reportedly uncommon. Here we report two cases illustrating metastases responding to systemic anticancer therapy (SACT). A 49-year-old woman with metastatic renal cell carcinoma treated with combination ipilimumab and nivolumab immunotherapy was referred for hypocortisolaemia (morning cortisol 74 nmol/l). Biochemical screening revealed an adrenocorticotropic hormone of 16ng/l (0-46), thyroid-stimulating-hormone 0.1mU/l (0.55-4.78), free thyroxine 7 pmol...

ea0077p224 | Neuroendocrinology and Pituitary | SFEBES2021

Three cases of metastatic spinal cord compression secondary to malignant pheochromocytoma and paraganglioma

Khan Amber , Kapoor Ashutosh , Manoharan Prakash , Chander Amarjot , Westwood Thomas , Woolf David , Hoong Ho Jan , Adam Safwaan

Approximately 15-20% of phaeochromocytomas and paragangliomas (PPGL) are metastatic. Metastatic spinal cord compression (MSCC) has been reported infrequently. We present three cases of MSCC secondary to metastatic PPGLs. MSCC can occur in patients with PPGLs and should be considered in patients with either spinal symptoms or spinal metastases on imaging. Our series has shown radiotherapy followed by therapeutic MIBG to be effective in treating spinal metastases. Each case shou...

ea0090p666 | Endocrine-related Cancer | ECE2023

A rare case of immunotherapy related adrenalitis

Ganawa Shawg , Mashamba Chiedza , Ilyas Waqas , Higham Claire , Cooksley Tim , Hoong Ho Jan , Adam Safwaan , Dhage Shaishav

Introduction: Immunotherapy has transformed the outcomes of various cancers. Monoclonal antibodies against cytotoxic T lymphocyte antigen 4 (CTLA4), programmed cell death 1 (PD1) and its ligand, PDL1 target mainly T cells, unleashing the immune system against tumour cells. Immune checkpoint inhibitor therapy results in a variety of immune related adverse events, including various endocrinopathies. Thyroid disorders, pituitary disorders are relatively more common compared to pr...

ea0086p45 | Endocrine Cancer and Late Effects | SFEBES2022

Emergency Ambulatory Outpatient Management of Immune Checkpoint Inhibitor-mediated Hypocortisolaeamia

Ganawa Shawg , Muhammad Haris , Knight Tom , Dhage Shaishav , Hoong Ho Jan , Gupta Avinash , Lorigan Paul , Higham Claire , Cooksley Tim , Adam Safwaan

Background: Immunotherapy mediated adrenocorticotrpic hormone (ACTH) deficiency is an important toxicity related to immune-checkpoint inhibitors (ICPi) potentially resulting in significant morbidity. Early diagnosis and optimal management are essential and frequently necessitate inpatient hospital treatment. We have previously reported an ambulatory management pathway for ICPi-induced ACTH deficiency in 4 patients. We sought to report the outcomes of this pathway in a larger c...

ea0094cc5 | Section | SFEBES2023

A case of an ACTH-secreting phaeochromocytoma: Biochemical response to metyrapone suggests the presence of a glucocorticoid-driven positive feedback loop

Michaelidou Maria , Phillips Benjamin , Man Mung Sai , Al-Hayali Mohammed , Chen Lilian , Allcock Rebecca , Monaghan Phillip , Thirkettle Sally , Clarke Noel , Gulamhusein Aziz , Beards Sue , Hoong Ho Jan , Kaushal Kalpana , Howell Simon , Adam Safwaan

Phaeochromocytoma-driven Ectopic ACTH Syndrome (EAS) is rare. We report the case of a 31-year-old female, who presented with abdominal pain and vomiting. She had clinical features of severe Cushing’s syndrome (proximal myopathy, bruising, refractory hypertension and acute confusion). Admission investigations revealed hypokalaemia (2.1mmol/l [3.5-5.5mmol/l]) and a 4.5cm left adrenal lesion with a ’bulky’ right adrenal on CT abdomen. She was diagnosed with hyperte...