Searchable abstracts of presentations at key conferences in endocrinology

ea0020p479 | Obesity and Metabolism | ECE2009

Short term elevation of estradiol concentrations does not affect hepatic VLDL-TG production

Gormsen Lars C , Host Christian , Gravholt Claus , Christiansen Jens S , Nielsen Soren

Background: Hormone replacement therapy (HRT) in post-menopausal women carries an increased risk of cardiovascular disease due to an unfavorable effect on lipid profile. Thus, HRT treatment increases concentrations of very-low-density-lipoprotein-triglycerides (VLDL-TGs) which have been demonstrated to possess atherogenic properties. However, the exact mechanisms whereby VLDL-TG concentrations are increased by estradiol are not fully understood. Estradiol acts on both rapid re...