Searchable abstracts of presentations at key conferences in endocrinology

ea0018p23 | (1) | MES2008

The need for a coordinated multidisciplinary approach in the management of morbid obesity

Mukherjee Leena , Hussain Sufyan , Flood John , Kaushal Rashmi

We describe the case of a 22-year-old South Asian male presenting to Endocrine Services with morbid obesity (BMI>50), sexual immaturity and agoraphobia. Born at full term following an uncomplicated pregnancy, he reached all developmental milestones appropriately. His problems began aged 15 after witnessing a murder, with reactive depression and hyperphagia. By the age of 18, he weighed over 140 kg, had poor self-image and suicidal ideation. He was managed initially by seve...

ea0021p178 | Diabetes and metabolism | SFEBES2009

Investigating the role of ventromedial hypothalamic glucose-sensing neurones in the response to hypoglycaemia

Richardson Errol , Sufyan Hussain Syed , Robert Counsell John , Bewick Gavin , Bloom Stephen , Gardiner James

Hypoglycaemia and hypoglycaemia unawareness severely limit the optimal management of diabetes mellitus and cause recurrent morbidity and even mortality in intensively controlled patients. Altered hypothalamic glucose sensing has been implicated in the development of defective counter regulatory responses to insulin induced hypoglycaemia and hypoglycaemic unawareness. This change in hypothalamic glucose sensing has been attributed, at least in part, to an increase in glucokinas...

ea0059oc3.5 | Obesity & diabetes | SFEBES2018

Hypothalamic arcuate glucokinase and its downstream pathways are critical in glucose homeostasis

Ratnasabapathy Risheka , Ma Yue , Izzi-Engbeaya Chioma , Nguyen-Tu Marie-Sophie , Richardson Errol , Hussain Sufyan , De Backer Ivan , Holton Christopher , Norton Mariana , Carrat Gaelle , Schwappach Blanche , Rutter Guy A , Dhillo Waljit S , Gardiner James V

As the nation gets fatter, the incidence of diabetes is also rising. The brain is now emerging as a critical mediator of blood sugar control, re-directing focus away from the traditional pancreas-centred model. The enzyme glucokinase (GK) acts as a glucose sensor in many tissues including glucose-sensitive neurones within the hypothalamic arcuate nucleus. However, the role of GK here is unclear. We investigated the role of arcuate GK in glucose homeostasis in both healthy and ...