Searchable abstracts of presentations at key conferences in endocrinology

ea0063p646 | Interdisciplinary Endocrinology 1 | ECE2019

Spingosine-1-phosphate induces cAMP/PKA-independent pCREB activation, but not steroidogenesis, in human granulosa cells

Paradiso Elia , Lazzaretti Clara , Riccetti Laura , Sperduti Samantha , Antoniani Francesco , Brigante Giulia , Feo Gaetano De , Morini Daria , Iannotti Francesca , Simoni Manuela , Poti Francesco , Casarini Livio

Sphingosine-1 phosphate (S1P) is a lysosphingolipid present in the ovarian follicular fluid at the nanomolar concentration. The physiological functions of S1P are mediated through five specific G protein-coupled receptors (GPCRs), known as S1PR1-5. S1PR1 and S1PR3 are expressed in human primary granulosa lutein cells (hGLC), as well as in the immortalized human primary granulosa cell line hGL5. S1PRs are activated at nanomolar concentrations inducing specific activation or inh...