Endocrine Abstracts

Background: Inflammatory cytokines in children with juvenile idiopathic arthritis (JIA) may modulate growth through systemic and local mechanisms.Aims: To study the relationship between inflammatory cytokines in serum /synovial fluid (SF) with growth and to assess the effects of serum/SF on the fetal rat metatarsal model.Subjects & Methods: 17 children with JIA (F,10): 8 oligoarticular, 2 extended oligoarticular, 6 polyarticula...

IntroductionCushing’s disease is the result of prolonged exposure to excess cortisol caused by a pituitary tumor, known as corticotropinoma, which hypersecretes adrenocorticotropin (ACTH). Treatment with somatostatin analogs (SSA) has been shown to reduce hormone secretion and, to a lower extent, tumor growth in some subtypes of pituitary tumors, such as growth hormone secreting tumors. However, SSA are commonly ineffective in corticotropinomas. Pre...

IntroductionDysregulation of alternative splicing is emerging as a new hallmark of cancer. This dysregulation may originate from mutations and/or altered expression of specific components of the splicing machinery. Indeed, our group has shown that the expression profile of the splicing machinery is altered in several types of cancer, including endocrine-related cancers. However, to date, the status of alternative splicing and its putative dysregulation h...