Endocrine Abstracts

Objective: We determined the prevalence of abnormal secretion of dopamine and other catecholamines in relation to clinical symptoms in patients with head and neck paragangliomas (PGL). The association of catecholamine production with nuclear imaging was also assessed.Methods: Thirty-six consecutive patients with head and neck PGLs, who were referred for follow-up and/or treatment between 1993 and 2009, were included. Clinical symptoms, dopamine excess (u...

Objectives: Thyroglobulin (Tg) is an established tumor marker for differentiated thyroid carcinoma (DTC) patients. However, Tg immunoassays can be subject to autoantibody (TgAb) interference resulting in incorrect Tg values. Tg measurement with liquid chromatography-tandem mass spectrometry (LC-MS/MS) could be promising in patients with TgAbs. In this study, we compared a Tg immunoradiometric assay (Tg-IRMA) and a Tg-LC-MS/MS analytically in the presence of TgAbs. Furthermore,...

Background: Patients with secondary adrenal insufficiency show increased risk of cardiovascular disease. Higher doses of glucocorticoid replacement are related to an unfavourable metabolic profile. In the absence of randomized controlled trials assessing the effect of hydrocortisone dose on haemodynamics and blood pressure regulation, we determined effects of a higher vs a lower glucocorticoid replacement dose on blood pressure, the renin-angiotensin-aldosterone system (RAAS) ...