Searchable abstracts of presentations at key conferences in endocrinology

ea0021oc1.1 | Diabetes and metabolism | SFEBES2009

IGF1 receptor and insulin receptor stoichiometry is a critical determinant of nitric oxide bioavailablity

Abbas Afroze , Viswambharan Hema , Imrie Helen , Rajwani Adil , Wheatcroft Stephen , Grant Peter , Kearney Mark

Introduction: Accumulating evidence suggests a role for IGF1 in insulin resistance and cardiovascular disease. IGF1 enhances glucose uptake and nitric oxide (NO) production, via similar mechanisms to insulin. Previously we have reported a mouse model with global heterozygous knockout of the IGF1 receptor (IGF1RKO) that has enhanced insulin sensitivity and increased nitric oxide (NO) production in the vasculature.Methods: To investigate this further we us...

ea0015p149 | Diabetes, metabolism and cardiovascular | SFEBES2008

Metabolic and vascular IGF-1 resistance is a marker of dietary-induced obesity

Imrie Helen , Viswambharan Hema , Rajwani Adil , Abbas Afroze , Cubbon Richard , Kahn Matthew , Gayle Chris , Wheatcroft Stephen , Kearney Mark

Endothelial dysfunction is a key step in the initiation of atherosclerosis, resulting from a decrease in bioavailability of nitric oxide (NO). IGF-1 may play a part in regulation of NO production via the PI3-kinase/Akt/eNOS pathway. We have investigated whether disturbances of this pathway occur in dietary-induced obesity.Obesity was induced in mice fed a high fat diet for 20 weeks (n=12), compared to chow fed controls, with an age-related increas...

ea0013p275 | Steroids | SFEBES2007

Genetic variation at the CYP11B locus accounts for heritabilities of aldosterone excretion and 11-beta hydroxylase activity

Freel E Marie , Imrie Helen , Avery Peter , Ingram Mary , Mayosi Bongani , Farrall Martin , Watkins Hugh , Fraser Robert , Davies Eleanor , Connell John , Keavney Bernard

Aldosterone is a key cardiovascular hormone: 15% of hypertensives have altered aldosterone regulation, defined by a raised ratio of aldosterone to renin. However, the causes of aldosterone excess are not understood. Polymorphic variation in the gene encoding aldosterone synthase (CYP11B2) is associated with hypertension, but the most robust phenotype is a relative reduction in efficiency of 11ß-hydroxylation (conversion of deoxycortisol to cortisol), which reflects functi...

ea0065p170 | Metabolism and Obesity | SFEBES2019

Chronic disruption of endothelial Insulin/IGF1 signaling pathway enhances whole body insulin sensitivity

Viswambharan Hema , Yuldasheva Nadira , Imrie Helen , Cubbon Richard , Bridge Katherine , Haywood Natalie , Skromna Anna , Porter Karen , Hemmings Karen , Clark Emily , Gatenby Victoria , Abudushalamu Yilizila , Cordell Paul , Simmons Katie , Makava Natallia , Walker Andrew , Futers Simon , Shah Ajay , Beech David , Wheatcroft Stephen , Kearney Mark , Sukumar Piruthivi

Type 2 diabetes is preceded by insulin resistance, followed by increased endothelial cell production of superoxide and reduction in bioavailability of the vasoprotective signalling molecule, nitric oxide (NO). We demonstrated in preclinical models that type 2 diabetes also causes resistance to insulin-like growth factor-1 (IGF-1) mediated glucose lowering and endothelial NO release. This study aimed to examine the effect of the endothelial cell-specific combination of insulin ...