Searchable abstracts of presentations at key conferences in endocrinology

ea0081p391 | Endocrine-Related Cancer | ECE2022

Effect of mitotane on male gonadal function

Innocenti Federica , Di Persio Sara , Taggi Marilena , Maggio Roberta , Lardo Pina , Elena Aloini Maria , Canipari Rita , Stigliano Antonio

Mitotane (MTT) currently represents the treatment of choice for adrenocortical carcinoma (ACC). Clinical evidence shows the occurrence of hypogonadism following treatment with this drug, observed more frequently in male patients. The aim of the study, therefore, was to evaluate the impact of MTT treatment on male gonadal function on adult CD1 mice. At the end of the 45 days of treatment, testes were collected for morphological examination, and a blood sample of each animal was...

ea0090p186 | Reproductive and Developmental Endocrinology | ECE2023

Gene expression differences between small and large follicles

Baschieri Lara , Cimadomo Danilo , Davolio Federica , Sperduti Samantha , Mascolo Elisa , Paradiso Elia , Lazzaretti Clara , Perri Carmela , Roy Neena , Innocenti Federica , Albricci Laura , Rienzi Laura , Vaiarelli Alberto , Maria Ubaldi Filippo , Simoni Manuela , Casarini Livio

In assisted reproduction, poor ovarian response to controlled ovarian stimulation (COS) leads to poor oocyte yield and depends on the genetic background. We compared the expression of key-genes, coding proteins regulating follicular development, between small (<10 mm) and large ovarian follicles (>16 mm), assuming the size as a hallmark of follicle maturation and oocyte fate. Twenty-two patients undergoing COS were enrolled in a fertility clinics. Granulosa cells and folli...