Endocrine Abstracts

Mitotane (MTT) currently represents the treatment of choice for adrenocortical carcinoma (ACC). Clinical evidence shows the occurrence of hypogonadism following treatment with this drug, observed more frequently in male patients. The aim of the study, therefore, was to evaluate the impact of MTT treatment on male gonadal function on adult CD1 mice. At the end of the 45 days of treatment, testes were collected for morphological examination, and a blood sample of each animal was...

In assisted reproduction, poor ovarian response to controlled ovarian stimulation (COS) leads to poor oocyte yield and depends on the genetic background. We compared the expression of key-genes, coding proteins regulating follicular development, between small (<10 mm) and large ovarian follicles (>16 mm), assuming the size as a hallmark of follicle maturation and oocyte fate. Twenty-two patients undergoing COS were enrolled in a fertility clinics. Granulosa cells and folli...