Searchable abstracts of presentations at key conferences in endocrinology

ea0031p315 | Steroids | SFEBES2013

11βHSD1 deficiency increases susceptibility to liver fibrosis by activating hepatic stellate cells

Zou Xiantong , Pellicoro Antonella , Aucott Rebecca , Ramachandran Prakash , Clarkson Michelle , Webster Scott P , Iredale John P , Walker Brian R , Michailidou Zoi

Background: Liver fibrosis in cirrhosis is characterized by accumulation of extracellular matrix from activated hepatic stellate cells (HSCs). Glucocorticoids (GCs) limit HSC activation in vitro. Local GC levels are regulated by 11β-hydroxysteroid dehydrogenase-1 (11βHSD1) which converts inactive GCs (11-dehydrocorticosterone) into active GCs (corticosterone). In this study we hypothesized that 11βHSD1 could potentially inhibit liver fibrosis.<p cla...

ea0059p169 | Obesity &amp; metabolism | SFEBES2018

Angiopoietin-like ptotein 4 and 8 (ANGPTL4 and ANGPTL8) in human fetal liver are dysregulated by in utero exposure to maternal smoking

Talia Chiara , Filis Panagiotis , Soffientini Ugo , Lucendo-Villarin Baltasar , Douglas Alex , Hay David , Shaw Sophie , Iredale John , Swortwood Madeleine , Huestis Marilyn , Bellingham Michelle , Connolly Lisa , O'Shaughnessy Peter , Fowler Paul

Introduction: Angiopoietin-like proteins (ANGPTLs) are a family of 8 glycoproteins with pleiotropic effects in metabolism, angiogenesis, inflammation and cancer. ANGPTL3, 4 and 8 play major roles in regulating lipid levels, via inhibition of lipoprotein lipase. Increased serum ANGPTL3, 4, 8 levels are associated with obesity, diabetes, metabolic syndrome and fatty liver. Furthermore, cord blood ANGPTL8 is higher than in maternal serum, suggesting a role in fetal development an...