Endocrine Abstracts

Background: A diagnosis of Addison’s disease means lifelong dependence on daily glucocorticoid and mineralocorticoid therapy and is associated with increased morbidity and mortality, as well as a risk of unexpected adrenal crisis. We wished to explore whether immunomodulatory therapy at an early stage of autoimmune Addison’s disease could lead to preservation or improvement in adrenal steroidogenic function.Design: We conducted an open-label, p...

Introduction: Subclinical hypothyroidism (SCH) is recognised as an increased risk for cardiovascular disease (CVD). Low number of circulating endothelial progenitor cells (EPC), defined as mononuclear cells, expressing endothelial (vascular endothelial growth factor receptor, VEGFR-2) and stem cell (CD-34, CD-133) markers is associated with CVD. Our aim was to identify whether reduced EPC number might contribute to increased CV risk in subclinical and overt hypothyroidism (Hy)...