Searchable abstracts of presentations at key conferences in endocrinology

ea0028oc3.5 | Obesity, thyroid and Addison's disease | SFEBES2012

Steroidogenic function following B lymphocyte depletion therapy in new onset autoimmune Addison’s disease

Pearce Simon , Mitchell Anna , Bennett Stuart , King Philip , Chandran Sukesh , Nag Sath , Chen Shu , Furmaniak Jadwiga , Isaacs John , Vaidya Bijay

Background: A diagnosis of AddisonÂ’s disease means lifelong dependence on daily glucocorticoid and mineralocorticoid therapy and is associated with increased morbidity and mortality, as well as a risk of unexpected adrenal crisis. We wished to explore whether immunomodulatory therapy at an early stage of autoimmune AddisonÂ’s disease could lead to preservation or improvement in adrenal steroidogenic function.Design: We conducted an open-label, p...

ea0015oc35 | Thyroid | SFEBES2008

Circulating endothelial progenitor cells are reduced in subclinical and overt hypothyroidism

Shakoor Abdul , Aldibbiat Ali , Ingoe Lorna , Campbell Susan , Sibal Latika , Isaacs John , Shaw James , Home Philip , Weaver Jolanta

Introduction: Subclinical hypothyroidism (SCH) is recognised as an increased risk for cardiovascular disease (CVD). Low number of circulating endothelial progenitor cells (EPC), defined as mononuclear cells, expressing endothelial (vascular endothelial growth factor receptor, VEGFR-2) and stem cell (CD-34, CD-133) markers is associated with CVD. Our aim was to identify whether reduced EPC number might contribute to increased CV risk in subclinical and overt hypothyroidism (Hy)...