Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 28 | SFEBES2012 | Next issue

Society for Endocrinology BES 2012

Oral Communications

Obesity, thyroid and Addison's disease

ea0028oc3.1 | Obesity, thyroid and Addison's disease | SFEBES2012

Metformin in obese children and adolescents (MOCA) trial

Kendall Deborah , Amin Rakesh , Barrett Timothy , Dimitri Paul , Ivison Fiona , Kibirige Mohammed , Mathew Verghese , Matyka Krystyna , Mc Govern Ann , Tetlow Lesley , Vail Andy , Wales Jerry , Wright Neil , Clayton Peter , Hall Catherine

Background and objective: Childhood obesity is associated with reduced insulin sensitivity and increased risk for type 2 diabetes (T2D). The objective of the MOCA trial was to investigate the effect of metformin in severely obese children and adolescents.Design and Methods: In a six month multi-centre randomized, double-blind placebo-controlled trial metformin (1.5 g daily) or placebo was given to children and adolescents (8–18 years) with insulin r...

ea0028oc3.2 | Obesity, thyroid and Addison's disease | SFEBES2012

Post-prandial high fat intake leads to acute exposure to circulating endotoxin in type 2 diabetes mellitus subjects

Harte Alison , Varma Madhusudhan , Tripathi Gyanendra , McGee Kirsty , Al-Daghri Nasser , Al-Attas Omar , Sabico Shaun , O'Hare Joseph , Ceriello Antonio , Saravanan Ponnusamy , Kumar Sudhesh , McTernan Philip

Habitual post-prandial absorption of saturated fatty acids (SFAs) increases systemic atherogenic lipoproteins and a pro-inflammatory response, a condition exacerbated by obesity, insulin resistance (IR) and type 2 diabetes mellitus (T2DM). Also, gut derived bacteria (endotoxin) is absorbed coupled to damaging lipoproteins as it crosses the mucosa, which could directly impact on adipose tissue, as our previous studies suggest. The current studies addressed whether a SFA rich me...

ea0028oc3.3 | Obesity, thyroid and Addison's disease | SFEBES2012

Risk of diabetes, cancer, large vessel disease and mortality in young women with Polycystic Ovary Syndrome: a retrospective database analysis

Morgan Chris , Jenkins-Jones Sara , Currie Craig , Rees Aled

Background: Polycystic Ovary Syndrome (PCOS) is associated with insulin resistance, hyperandrogenism and dyslipidaemia but the effects of these disturbances on long-term health are not known.Aims: To determine the relative risk of diabetes, cancer, large vessel disease (LVD) and death for young women diagnosed with PCOS.Design: Data were extracted from The General Practice Research Database (GPRD), a longitudinal, anonymised resear...

ea0028oc3.4 | Obesity, thyroid and Addison's disease | SFEBES2012

Glucose absorption capacity of the mature adipose tissue is increased after Bardet-Biedl syndrome induced ciliary defect in adipocytes’ precursors

Marion Vincent

A defining trait of modern civilization is easy access to food combined with minimum energy expenditure. This unbalance is responsible for the emergence of considerable wide-spread obesity and its harrowing cortege of life-threatening complications such as type-2 diabetes. Rare genetic disorders that manifest with obesity are of great value in discovering new pieces of the jigsaw on the origins of obesity as they allow us to link a phenotype with a specific protein or group of...

ea0028oc3.5 | Obesity, thyroid and Addison's disease | SFEBES2012

Steroidogenic function following B lymphocyte depletion therapy in new onset autoimmune Addison’s disease

Pearce Simon , Mitchell Anna , Bennett Stuart , King Philip , Chandran Sukesh , Nag Sath , Chen Shu , Furmaniak Jadwiga , Isaacs John , Vaidya Bijay

Background: A diagnosis of Addison’s disease means lifelong dependence on daily glucocorticoid and mineralocorticoid therapy and is associated with increased morbidity and mortality, as well as a risk of unexpected adrenal crisis. We wished to explore whether immunomodulatory therapy at an early stage of autoimmune Addison’s disease could lead to preservation or improvement in adrenal steroidogenic function.Design: We conducted an open-label, p...

ea0028oc3.6 | Obesity, thyroid and Addison's disease | SFEBES2012

GATA3 polymorphisms are associated with autoimmune Addison’s disease

Mitchell Anna , MacArthur Katie , Gan Earn , Baggott Lucy , Wolff Anette , Skinningsrud Beate , Short Andrea , Kampe Olle , Bensing Sophie , Betterle Corrado , Kasperlik-Zaluska Anna , Czarnocka Barbara , Fichna Marta , Hulting Anna-Lena , Badenhoop Klaus , Falorni Alberto , Ollier William , Undlien Dag , Husebye Eystein , Pearce Simon

Autoimmune Addison’s disease (AAD) is a rare, highly heritable endocrinopathy with an estimated λsibling (ratio of risk to a sibling vs the unrelated background population) of 160–210. The majority of the genetic risk to AAD has yet to be accounted for. We have used a tag-SNP approach to seek association between single nucleotide polymorphisms (SNPs) in the GATA3 gene and autoimmune Addison’s disease (AAD). 2001 AAD cases and 1898 controls were included in ...

ea0028oc3.7 | Obesity, thyroid and Addison's disease | SFEBES2012

Subclinical hypothyroidism is associated with fatigue and impaired functional status in males in the Whickham 20-year follow up cohort

Madathil Asgar , Razvi Salman , Vanderpump Mark , Pearce Simon , Weaver Jolanta

Introduction: The association between fatigue, functional status and subclinical hypothyroidism (SCH) remains unclear. The available data is not consistent, and this is likely to be due to selection bias in studies recruiting patients from clinic rather than unselected community populations. Only population surveys looking at prevalence of fatigue and functional status in SCH are likely to provide the answer.Objective and Methodology: We compared the pre...

ea0028oc3.8 | Obesity, thyroid and Addison's disease | SFEBES2012

Dietary factors augment the ability of the proto-oncogene PBF to induce goitrogenesis and hyperplasia in vivo

Read Martin , Smith Vicki , Lewy Greg , Ryan Gavin , Sharma Neil , Seed Robert , Fong Jim , Kwan Perkin , Warfield Adrian , Leadbeater Wendy , Watkinson John , Franklyn Jayne , Boelaert Kristien , McCabe Chris

Nodular thyroid disease is common and its pathogenesis remains poorly understood. Previously, we showed that thyroid-targeted overexpression of the proto-oncogene PTTG-Binding Factor (PBF) induced striking thyroid gland enlargement in transgenic mice (PBF-Tg)1. We have now investigated whether dietary factors influence goitrogenesis and the development of hyperplastic lesions in PBF-Tg mice. The mean weight of thyroids (5.8±0.9 mg; n=70) from 7 week old ...