ea0029p701 | Diabetes | ICEECE2012
Miyamoto L.
, Kono M.
, Nakagawa T.
, Hattori H.
, Ishizawa K.
, Yoshimura Y.
, Nemoto H.
, Tsuchiya K.
Probucol is a traditional anti-hyperlipidemic agent harboring marked antioxidant activity. While probucol is highly hydrophobic, its succinic acid ester, succinobucol, was reported as a water-soluble derivative and was in clinical trials. Succinobucol was shown to be more potent in lipid-lowering, anti-inflammatory and anti-atherogenic effects than probucol in animal models. In addition, succinobucol reduced HbA1c in diabetic patients. Although the clinical trials finally ende...