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Endocrine Abstracts

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ea0090oc6.3 | Oral Communications 6: Endocrine-related Cancer | ECE2023

Tumor microenvironment of adrenocortical carcinoma dissected by single-cell RNA-sequencing

Jouinot Anne , Martin Yoann , Foulonneau Thomas , Bendjelal Yanis , Calvet Philip , Violon Florian , Sibony Mathilde , Daniel De Murat , Armignacco Roberta , Perlemoine Karine , Letourneur Franck , Izac Brigitte , Andrieu Muriel , Berthon Annabel , Ragazzon Bruno , Groussin Lionel , Libe Rossella , Bertherat Jerome , Assie Guillaume

Background: Molecular classification is important for diagnosis and prognosis of adrenocortical tumors (ACT). Transcriptome profiles separate benign ACT (“C2” cluster) from carcinomas (ACC) and identify two groups of ACC, “C1A” (“steroid” and “proliferation” signatures) and “C1B” (“immune” signature), of poor and better prognosis respectively. However, these signatures were characterized at the tissue level (“bul...
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ea0070yi12 | Young Investigators | ECE2020

Identification of transcriptome profiles in paraffin samples using 3’ RNA-sequencing for the prognostic assessment of adrenocortical carcinoma

Jouinot Anne , Sibony Mathilde , Jeanpierre Lindsay , Septier Amandine , De Murat Daniel , Armignacco Roberta , Perlemoine Karine , Izac Brigitte , Letourneur Franck , Ragazzon Bruno , Leroy Karen , Gaujoux Sebastien , Dousset Bertrand , Groussin Lionel , Libe Rossella , Bertherat Jerome , Assié Guillaume

Background: Adrenocortical cancer (ACC) is an aggressive tumor with heterogeneous prognosis. Previous genomic studies have demonstrated the importance of molecular classification for the prognostic assessment. Among molecular markers, transcriptome profiles “C1A” (steroid and proliferative signature) and “C1B” (immune signature) show the strongest association with outcome. However these markers are determined so far only from frozen tissue samples, sinc...
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ea0099oc7.4 | Oral Communications 7: Endocrine-related Cancer | ECE2024

Single-nucleus atlas of adrenocortical carcinoma reveals tumor ecotypes associated with outcome

Assie Guillaume Jouinot Anne , Martin Yoann , Foulonneau Thomas , Bendjelal Yanis , Violon Florian , Calvet Philip , Izac Brigitte , Letourneur Franck , Bertholle Celine , Andrieu Muriel , Onifarasoaniaina Rachel , Favier Maryline , De Guitaut Charlene , Fraikin Archibald , De Murat Daniel , Armignacco Roberta , Benanteur Nesrine , Sibony Mathilde , Perlemoine Karine , Bonnet Fideline , Gaillard Martin , Dousset Bertrand , Pasmant Eric , Barat Maxime , Dohan Anthony , Haissaguerre Magalie , Tabarin Antoine , Libe Rossella , Guignat Laurence , Groussin Lionel , Berthon Annabel , Ragazzon Bruno , Bertherat Jerome , Assie Guillaume

Background: Bulk genomic studies have identified distinct molecular classes of adrenocortical tumors (ACT). Transcriptome profiles separate benign ACT (“C2” cluster) from carcinomas (ACC) and identify two groups of ACC, “C1A” (“steroid” and “proliferation” signatures) and “C1B” (“immune” signature), of poor and better prognosis respectively. However, these signatures were characterized at the tissue level (“bulk&...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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