Searchable abstracts of presentations at key conferences in endocrinology
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22nd European Congress of Endocrinology

Online
05 Sep 2020 - 09 Sep 2020

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Europe's leading endocrinology congress showcasing the very best in the study and treatment of endocrine disorders.

Oral Communications

Young Investigators

ea0070yi1 | Young Investigators | ECE2020

A mixed nutrient preload attenuates glucose-induced endothelial dysfunction in individuals with abnormal glucose tolerance

Trico Domenico , Nesti Lorenzo , Mengozzi Alessandro , Baldi Simona , Natali Andrea

Background: Postprandial hyperglycemia is an independent risk factor for cardiovascular disease and all-cause mortality. This excess cardiovascular risk may be partly explained by the impairment in endothelial function that typically follows an acute increase in plasma glucose levels. Recently, nutritional interventions focused on the sequence of macronutrient consumption within the meal have been proposed to normalize postprandial glycemia in subjects with abnormal glucose to...

ea0070yi2 | Young Investigators | ECE2020

Transcriptomic response of mouse thyroid to iodine by upregulating Nrf2-dependent and independent pathways

Chartoumpekis Dionysios , Ziros Panos , Habeos Ioannis , Kyriazopoulou Venetsana , Smith Adam , Marques Ana Claudia , Sykiotis Gerasimos

Introduction: Nrf2 (Nfe2l2) is a transcription factor that regulates a series of cytoprotective and antioxidant enzymes. Upon exposure to oxidative or electrophilic stress, Nrf2 enters the nucleus and induces its target genes expression. Follicular thyroid cells have physiologically high levels of reactive oxygen species as oxidation of iodine is essential for iodination of thyroglobulin and thyroid hormones synthesis. We have shown previously that Nrf2 pathway is active in th...

ea0070yi3 | Young Investigators | ECE2020

RNA-sequencing of adrenocortical tumors reveals novel pathogenetic insights

Di Dalmazi Guido , Altieri Barbara , Scholz Claus , Sbiera Silviu , Luconi Michaela , Waldmann Jens , Kastelan Darko , Ceccato Filippo , Chiodini Iacopo , Arnaldi Giorgio , Osswald Andrea , Reincke Martin , Beuschlein Felix , Sauer Sascha , Fassnacht Martin , Appenzeller Silke , Ronchi Cristina

Background: Genetic alterations underlying the pathogenesis of autonomous cortisol secretion and early adrenocortical tumorigenesis have been identified in 40% of adrenocortical tumors (ACT). Nonetheless, the molecular events leading to development of ACT and steroid secretion remain obscure for a large proportion of patients.Aim: Aims of our study were to investigate the relationship between transcriptome profile and genetic background in a large series...

ea0070yi4 | Young Investigators | ECE2020

Evidence for increased SSTR5 expression and improved pasireotide response in USP8 mutant corticotroph tumours

Albani Adriana , Perez-Rivas Luis Gustavo , Sicheng Tang , Buchfelder Michael , Rotermund Roman , Flitsch Jörg , Losa Marco , Stalla Günter , Reincke Martin , Theodoropoulou Marily

The somatostatin analogue pasireotide is approved for the treatment of Cushing’s disease, where it achieves biochemical normalization in ~40% of patients. Predicting pasireotide resistance would help avoid unnecessary treatment. Pasireotide mediates its antisecretory action by binding to somatostatin receptor 5 (SSTR5). Almost half of corticotroph tumours carry mutations in the ubiquitin specific protease 8 (USP8) gene that encodes for a deubiquitinase. Pre...

ea0070yi5 | Young Investigators | ECE2020

Splicing machinery is dysregulated in craniopharyngiomas: a novel source of diagnostic, prognostic and therapeutic biomarkers

Fuentes-Fayos Antonio C , Sanchez-Medianero Teresa , Cano David A , Martínez-Ortega Antonio J , Toledano-Delgado Álvaro , Dios Elena , Venegas-Moreno Eva , Cárdenas Eugenio , Martínez-Barbera Juan P , Castaño Justo P , Soto-Moreno Alfonso , Ortega Salas Rosa M , Luque Raúl M

Craniopharyngiomas are rare benign epithelial tumors derived from remains of Rathke’s pouch. They are more prevalent in childhood, adolescence, and adults <50 years, and, commonly, are usually diagnosed after being associated with serious comorbidities when the development of the tumor is already advanced. To date, first-line therapy is usually surgery, but frequently the resection is not complete, causing high rates of recurrence. Therefore, the identification of ne...

ea0070yi6 | Young Investigators | ECE2020

Dysregulation of splicing factor 3B SUBUNIT 1 (SF3B1) is associated with the pathological transformation of the liver: Pharmacological inhibition with pladienolide-B as novel therapeutic tool in liver disease

Jiménez Vacas1 Juan Manuel , López-Cánovas Juan L , Del Rio-Moreno Mercedes , García-Fernandez Helena , Sánchez-Frias Marina E , Amado Victor , L-López Fernando , Fondevila Marcos F , Ciria Ruben , Briceño Javier , Nogueiras Rubén , De la Mata Manuel , Castaño Justo P , Rodriguez-Perálvarez Manuel , Luque Raúl M , Gahete Manuel D

Development and progression of liver diseases, from non-alcoholic fatty liver disease (NAFLD) to steatohepatitis (NASH), and hepatocellular carcinoma (HCC), seem to be accompanied by a dysregulation of the expression of alternative splicing variants (SVs) and appearance of aberrant SVs. The splicing factor 3B subunit 1 (SF3B1) represents a crucial player for the functional assembly of the spliceosome, the core machinery that controls the splicing process, and its activity can ...

ea0070yi7 | Young Investigators | ECE2020

Congenital isolated follicle-stimulating hormone deficiency due to the FSHB gene mutation in a female patient – a rare case report

Paczkowska Katarzyna , Kolanowska Monika , Wikiera Beata , Bolanowski Marek , Jażdżewski Krystian , Daroszewski Jacek

Introduction: Mutations in FSHβ gene leading to isolated follicle-stimulating hormone (FSH) deficiency are very rare and the disorder is inherited in an autosomal recessive manner. Up to date, only few case reports have been described in the literature.Case report: 25-years old woman was admitted to the Endocrinology Department with a suspicion of FSH deficiency. She was firstly diagnosed with primary amenorrhoea and impaired pubertal development at...

ea0070yi8 | Young Investigators | ECE2020

Towards the development of an in vitro 3D human thyroid model

Vural Özlem , Daher Ugarit , Kadler Shirin , Mogl Martina , Goretzki Peter , Lauster Roland

Human and animal health has been exposed to endocrine disruptors (EDs) which are chemicals found in pesticides, food or personal care products. The main concern about these disruptors is caused by their interference with the endocrine system causing adverse effects, such as altered reproduction, abnormal neurological development in newborns and children or an elevated susceptibility to hormone-related cancers. The thyroid gland and its hormones belong to major targets that are...

ea0070yi9 | Young Investigators | ECE2020

Comparison between the efficacy of the Anti-BAFF monoclonal antibody belimumab vs methylprednisolone in active moderate-severe graves’ orbitopathy: an interim analysis

lazzaroni Elisa , Covelli Danila , Currò Nicola , Campi Irene , Vannucchi Guia , Dazzi Davide , Muller Ilaria , Guastella Claudio , Dolci Alessia , Arosio Maura , Salvi Mario

Background: BAFF is a Serum B cell stimulating factor shown elevated in Graves’ disease, compared to controls (Vannucchi 2012). BAFF and its receptor are expressed on lymphocytes infiltrating the thyroid in Graves’ disease as well as on thyrocytes themselves (Campi 2015).Aims: A single-blind randomized controlled trial (EudraCT 2015-002127-26) has been conducted to test the efficacy of the anti-BAFF monoclonal antibody belimumab (BMB) in acti...

ea0070yi10 | Young Investigators | ECE2020

Association of dietary and plasma fatty acids with adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) gene expression in human adipose tissues

Yuzbashian Emad , Asghari Golaleh , Zarkesh Maryam , mirmiran Parvin , Hedayati Mehdi , Khalaj Alireza

Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) are key enzymes involved in intracellular degradation of triacylglycerols. The environmental factors and circulating biomarkers can affect the expression of ATGL and HSL in adipocytes among rats. To our knowledge, however, no information is known about the dietary and plasma fatty acids composition on gene expression of ATGL and HSL in human adipose tissue. We aimed to determine how fatty acid species measur...

ea0070yi11 | Young Investigators | ECE2020

Growth hormone-releasing hormone (GHRH) antagonists increase the sensitivity to radiotherapy in lung cancer cells

Gesmundo Iacopo , Dematteis Alessandro , Fanciulli Alessandro , Romana Giglioli Francesca , Cai Renzhi , Sha Wei , Ricardi Umberto , Ghigo Ezio , Schally Andrew V , Granata Riccarda

Growth hormone-releasing hormone (GHRH), apart from stimulating GH secretion in the pituitary, exerts many extrapituitary functions, including stimulation of cell proliferation and survival. GHRH and its receptor splice variants (SVs) are expressed in different cancer cell types, where they modulate cell growth. It has been shown that GHRH antagonists exert anticancer activities in a variety of tumors, including malignant pleural mesothelioma and lung cancer, one of the leadin...

ea0070yi12 | Young Investigators | ECE2020

Identification of transcriptome profiles in paraffin samples using 3’ RNA-sequencing for the prognostic assessment of adrenocortical carcinoma

Jouinot Anne , Sibony Mathilde , Jeanpierre Lindsay , Septier Amandine , De Murat Daniel , Armignacco Roberta , Perlemoine Karine , Izac Brigitte , Letourneur Franck , Ragazzon Bruno , Leroy Karen , Gaujoux Sebastien , Dousset Bertrand , Groussin Lionel , Libe Rossella , Bertherat Jerome , Assié Guillaume

Background: Adrenocortical cancer (ACC) is an aggressive tumor with heterogeneous prognosis. Previous genomic studies have demonstrated the importance of molecular classification for the prognostic assessment. Among molecular markers, transcriptome profiles “C1A” (steroid and proliferative signature) and “C1B” (immune signature) show the strongest association with outcome. However these markers are determined so far only from frozen tissue samples, sinc...