Searchable abstracts of presentations at key conferences in endocrinology
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22nd European Congress of Endocrinology

05 Sep 2020 - 09 Sep 2020

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Europe's leading endocrinology congress showcasing the very best in the study and treatment of endocrine disorders.

Oral Communications

Reproductive and Developmental Endocrinology

ea0070oc9.1 | Reproductive and Developmental Endocrinology | ECE2020

Identification of a novel hypothalamic miRNA/Kisspeptin pathway as pathophysiological mechanism and putative target for management of obesity-induced hypogonadism

Perdices López Cecilia María , Avendaño Herrador María Soledad , Vázquez Villar María Jesús , Barroso Romero Alexia , Ruiz Pino Francisco , Morrugares Carmona Rosario , Correa Sáez Alejandro , Antonio Calzado Marco , Castellano Rodríguez Juan Manuel , Briones Alonso Ana María , Tena-Sempere Manuel

Among its numerous comorbidities, obesity is often linked to central hypogonadism in men, i.e., low circulating levels of gonadotropins and testosterone. While this condition of obesity-induced hypogonadism (OIH) is frequently neglected, it has been suggested to contribute to the metabolic complications of male obesity. However, the mechanisms of OIH, and even its actual role in the metabolic alterations of obesity remain ill defined. Our recent data suggest that OIH is bound ...

ea0070oc9.2 | Reproductive and Developmental Endocrinology | ECE2020

Kisspeptin as a biomarker for pregnancy complications

Phylactou Maria , Abbara Ali , Chia Eng Pei , Al-Memar Maya , Comninos Alexander , Nadir Rans , Izzi-Engbeaya Chioma , Clarke Sophie , Mills Edouard , Sykes Mark , Pacuszka Ewa , Yang Lisa , Fourie Hanine , Bech Paul , Kelsey Tom , Bourne Tom , Dhillo Waljit

Background: Placentation (invasion of the placenta into the maternal endometrium of pregnancy known as the decidua) is hypothesised to be critical for healthy placental function and is abnormal in two thirds of miscarriage. Kisspeptin has emerged as a putative regulator of physiological placentation; it is highly expressed in placental syncitio-trophoblasts, whereas its receptor is expressed in both syncitio- and cyto-trophoblasts, such that kisspeptin is hypothesized to play ...

ea0070oc9.3 | Reproductive and Developmental Endocrinology | ECE2020

Association between an AMH promoter polymorphism and serum AMH levels in PCOS patients

Moolhuijsen Loes , Louwers Yvonne V , Meun Cindy , Broer Linda , Uitterlinden Andre G , Sisk Ryan K , Dunaif Andrea , Laven Joop SE , Visser Jenny A

Introduction: Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age, is diagnosed based on three criteria, including a polycystic ovarian morphology. Moreover, women with PCOS have elevated serum Anti-Müllerian Hormone (AMH) levels, a hormone known to correlate with follicle number. In addition, AMH production per follicle is suggested to be higher in PCOS. Little is known about AMH gene regulation. Hence, this study aims to inv...

ea0070oc9.4 | Reproductive and Developmental Endocrinology | ECE2020

Demonstration of follicle-stimulating hormone receptor and G protein-coupled estrogen receptor heteromers in vitro via BRET and super-resolution imaging

Lazzaretti Clara , Sayers Niamh , Paradiso Elia , Sperduti Samantha , Fanelli Francesca , Simoni Manuela , Hanyaloglu Aylin , Casarini Livio

Introduction: The developmental stages of the ovarian follicle are characterized by changes of gonadotropin and steroid hormone receptor expression and their potential interactions on the surface of granulosa cells. In this study in vitro, we aim to evaluate whether the co-existing follicle-stimulating hormone receptor (FSHR) and G protein-coupled estrogen receptor (GPER) form heteromers, which may play role in selecting the dominant ovarian follicle.<p class="abs...

ea0070oc9.5 | Reproductive and Developmental Endocrinology | ECE2020

Genetic dissection of spermatogenic arrest through whole exome analysis: Clinical implications for the management of azoospermic men

Riera_Escamilla Antoni , Moreno-Mendoza Daniel , Holleman Kaylee , Casamonti Elena , Cioppi Francesca , Pietroforte Sara , Ruiz-Castané Eduard , Baarends Willy , Krausz Csilla

Background: Non-obstructive azoospermia affects about 1% of men and has a multifactorial etiology with heterogeneous testicular histology. Pure spermatogenic maturation arrest (MA) is a relatively rare NOA phenotype but its clinical relevance is high, since patients affected by MA should not undergo invasive testis surgery. A clear-cut distinction between MA and other spermatogenic disturbances leading to azoospermia is not possible with the currently available clinical tools....

ea0070oc9.6 | Reproductive and Developmental Endocrinology | ECE2020

Testosterone replacement therapy of opioid induced male hypogonadism improved body composition but not pain perception A double-blinded, randomized and placebo-controlled trial

Glintborg Dorte , Bjarke Vægter Henrik , Lehmann Christensen Louise , Bendix Emma , Graven-Nielsen Thomas , Andersen Per Grunwald , Andersen Marianne

Background: Hypogonadism is prevalent during opioid treatment, but the effect of testosterone replacement treatment (TRT) on body composition, pain perception, and adrenal function is unclear.Purpose: To measure changes in body composition, pain perception, quality of life and adrenal function after TRT or placebo in opioid treated men with chronic non-malignant pain.Methods: Double-blinded, placebo-controlled study in 41 men (&#62...