Endocrine Abstracts

Case History: A 26-year-old woman with known metastatic adrenocortical carcinoma (ACC) was transferred to our department with recurrent severe hypoglycaemic episodes. Her ACC was diagnosed in 2018 and a 175 × 130 × 89 mm 1200 g mass was surgically resected (ENS@T stage-II, Weiss score-5, Ki-67 20%, Helsinki score-28). Her disease progressed despite adjuvant radiotherapy, mitotane and three chemotherapy regimens. In January 2023, she began experiencing episodes of pro...

Background: The ESE-ENSAT guidelines emphasize the role of local therapies and suggest radiotherapy (RT) as an individualized treatment in patients with advanced ACC. However, the evidence for this recommendation is very low.Objectives: The aim of this study was to retrospectively investigate the efficacy and tolerance of RT in advanced ACC.Methods: We screened all patients in five European reference centers for ACC since 2000 for ...