Endocrine Abstracts

Background: Prostate cancer (PCa) is one the leading causes of cancer-related deaths among men in developed countries. Therefore, the identification of novel molecular targets for treatment is urgently needed to improve patients’ outcomes. In this scenario, our group has recently reported that elements of the cellular machinery controlling alternative-splicing processes might be used as potential novel therapeutic tools for PCa. In this context, although RBM22 has been id...

Background: Adrenocortical carcinoma (ACC) is an aggressive cancer originating from steroidogenic cells within the adrenal cortex. Unfortunately, half of patients present with metastatic spread upon initial diagnosis, and there is no curative therapy for advanced disease. Genomic analysis has identified that the most aggressive subgroup of ACC patients have overlapping alterations in the WNT/β-catenin pathway and the p53/RB signaling pathway.Objecti...

Introduction: Mitotane is an adrenolytic drug which is used in patients with adrenocortical carcinoma (ACC) and leads to adrenal insufficiency (AI). The aim of this study was to evaluate the time to recovery of the hypothalamus-pituitary-adrenal (HPA) axis after adjuvant mitotane treatment and to determine possible predictive factors.Materials and Methods: In this retrospective study, we included 19 patients with ACC, ENSAT stage I- III, who were treated...

Background: The ESE-ENSAT guidelines emphasize the role of local therapies and suggest radiotherapy (RT) as an individualized treatment in patients with advanced ACC. However, the evidence for this recommendation is very low.Objectives: The aim of this study was to retrospectively investigate the efficacy and tolerance of RT in advanced ACC.Methods: We screened all patients in five European reference centers for ACC since 2000 for ...

Adrenocortical carcinoma (ACC) is a very severe endocrine malignancy with poor prognosis. While cancer immunotherapies have revolutionized the treatment of several cancer entities, the results of initial studies of different immune checkpoint inhibitors in ACC were heterogeneous and clinically substantial responses were observed only in a subset of patients. Expression of immune checkpoint molecules - programmed cell death 1 (PD-1), its ligand PD-L1 and cytotoxic T Lymphocytes...

Background: Adrenocortical carcinoma is a rare endocrine malignancy with poor prognosis and few treatment options in advanced disease. Immune checkpoint inhibitors (ICI) have been studied in few clinical trials with a limited number of patients in ACC. No real-life data are available so far. In the present study we aimed at evaluating treatment response and safety of ICI treatment in advanced ACC and identifying clinical, biochemical, histological and molecular markers for pre...

Background: Papillary thyroid carcinomas are the most common thyroid malignancies. They are more prevalent in women and have a bimodal age distribution. Thyroglossal duct cyst carcinomas are extremely rare (occurring in only 1% of all thyroglossal duct cysts). The large majority of these carcinomas are of thyroid origin.Case presentation: A 25-year-old woman with no significant medical history was referred to the Endocrinologist with 1-month complaints o...

Primary squamous cell carcinoma of the thyroid gland (PSCCT) is a rare neoplasm of the thyroid with a poor prognosis. We present a 70-year-old male patient who presented with a progressively growing mass on the left side of the neck causing shortness of breath. The patient presented with suspicious poorly-differentiated malignancy as a result of the thyroid fine-needle aspiration cytology performed due to the rapidly growing mass. No other primary tumor focus was detected in t...

Background: Primary thyroid angiosarcoma (PTA), previously considered a vascular type of anaplastic thyroid carcinoma (ATC), is a rare, aggressive malignant mesenchymal tumor, with a peak incidence in the seventh decade of life. PTA can present as an ATC, a more frequent type of thyroid malignancy. Differential diagnosis is of major importance, as the management and prognosis differ significantly.Case report: A 72-year-old woman presented for a 2 month h...

Background: Prostate cancer is the most commonly diagnosed male malignancy. Androgen Deprivation Therapy (ADT) with GnRH agonist is commonly used intreating localized prostate cancer. Side effect of ADT is a loss of bone density resulting inosteopenia or osteoporosis. Research concerningpossible molecular and cellular mechanisms of ADT-induced bone changes are still incomplete. Matrix Gla Protein (MGP) is a vitamin-K-dependent protein which is synthesized in a variety of tissu...

Background: Papillary thyroid carcinoma (PTC) arising within an ovarian teratoma is an extremely rare condition that comes with certain difficulties in the preoperative diagnosis and postoperative treatment strategy. It is either asymptomatic (detected incidentally) or with nonspecific symptoms. Currently, no consensus exists on the surgical and postoperative treatment of patients with malignant struma ovarii.Case presentation: A 26-year-old female prese...