Searchable abstracts of presentations at key conferences in endocrinology

ea0029p831 | Endocrine tumours and neoplasia | ICEECE2012

Non pituitary effects of GnRH analogues in prostate cancer cells: revertion of maligant phenotype and synergism with bicalutamide and radiotherapy

Festuccia C. , Gravina G. , Marampon F. , Piccolella M. , Motta M. , Lenzi A. , Tobolini V. , Jannini E.

Background: Gonadotropin-releasing hormone (GnRH) receptor is a G protein-coupled receptor involved in the synthesis and release of pituitary gonadotropins. GnRH analogs constitute the most widely employed medical treatment for prostatic cancer. The predominant mechanism of action is presumed to be via the inhibition of gonadotropins and resultant decrease in androgen. Although pituitary and extra-pituitary GnRH-R transcripts appear identical, their functional characteristics ...

ea0029p1042 | Male Reproduction | ICEECE2012

Premature ejaculation and erectile dysfunction in a cohort of infertility men: clinical and ultrasonographic correlations

Lotti F. , Corona G. , Rastrelli G. , Forti G. , Jannini E. , Maggi M.

Introduction: Premature ejaculation (PE) and erectile dysfunction (ED) are considered pre-testicular causes of male subfertility. No previous study systematically evaluated the prevalence of ED and PE along with their possible correlations with clinical and colour-Doppler ultrasound (CDU) features in infertile men.Methods: Ejaculatory status, erectile function, prostatitis symptoms and psychopathological traits of 244 men complaining of couple infertilit...

ea0029p1052 | Male Reproduction | ICEECE2012

SIEDY scale 3, a new instrument to detect intrapsychic component in subjects with erectile dysfunction

Corona G. , Ricca V. , Bandini E. , Rastrelli G. , Casale H. , Jannini E. , Sforza A. , Forti G. , Mannucci E. , Maggi M.

Introduction: We previously developed and validated a structured interview (SIEDY) dealing with the organic (scale 1), relational (scale 2) and intrapsychic (scale 3) components of erectile dysfunction (ED). The aim of the present study is to identify a pathological threshold for SIEDY scale 3 and to analyze scale 3 score with biological and psychological correlates in subjects with sexual dysfunction.Method: A pathological threshold of SIEDY scale 3 sco...

ea0029p482 | Developmental endocrinology | ICEECE2012

Dimensional profiles of male to female gender identity disorder: an exploratory research

Fisher A. , Bandini E. , Ricca V. , Ferruccio N. , Corona G. , Meriggiola M. , Jannini E. , Manieri C. , Forti G. , Mannucci E. , Maggi M.

Introduction: Male-to-female gender identity disorder (MtF GID) is a complex phenomenon that could be better evaluated by using a dimensional approach.Aim: To explore the aggregation of clinical manifestations of MtF GID in order to identify meaningful variables describing the heterogeneity of the disorder.Methods: A consecutive series of 80 MtF GID subjects (mean age 37±10.3 years), referred to the interdepartmental Center fo...

ea0029p494 | Developmental endocrinology | ICEECE2012

Childhood maltreatment in subjects with male to female gender identity disorder

Fisher A. , Bandini E. , Ricca V. , Meriggiola M. , Jannini E. , Manieri C. , Corona G. , Monami M. , Forti G. , Mannucci E. , Maggi M.

Introduction: Childhood maltreatment is quite common and constitutes a non-specific risk factor for a range of different emotional and behavioural problems during lifespan. It has been demonstrated that sexual minorities are at higher risk of maltreatment and abuse, and a high proportion of transsexual subjects reports childhood maltreatment.Aim: To evaluate the prevalence of reported childhood maltreatment in a clinical sample of patients with male to f...

ea0029p832 | Endocrine tumours and neoplasia | ICEECE2012

Histone deacetylase inhibitor belinostat (PXD-101) represses androgen receptor expression and acts synergistically with castration and bicalutamide treatment to inhibit prostate cancer growth in hormone refractory models

Festuccia C. , Gravina G. , Marampon F. , Muzi P. , Mancini A. , Piccolella M. , Negri-Cesi P. , Motta M. , Tobolini V. , Lenzi A. , Jannini E.

Rationale and aims: Aberrant activation or “reactivation” of androgen receptor in the course of androgen-ablation therapy shows a potential cause for the development of castration-resistant prostate cancer. This study tested the hypothesis that belinostat (PXD101), a potent pan histone deacetylase inhibitor, may potentiate hormonal therapy and prevent onset of castration resistant phenotype Material and Methods. A panel of human prostate cancer (Pca) cells with grade...

ea0029p848 | Endocrine tumours and neoplasia | ICEECE2012

Hormonal Therapy Promotes Hormone-Resistant Phenotype by Increasing DNMT Activity and Expression in Prostate Cancer Models

Gravina G. , Festuccia C. , Piccolella M. , Motta M. , Ventura L. , Pomante R. , Zani B. , Pestell R. , Tombolini V. , Lenzi A. , Jannini E.

We hypothesized that hormonal therapy favors the development of the hormone-resistant (HR) phenotype through epigenetic mechanisms. Human prostate cancer (Pca) tissues and in vitro and in vivo models were used to verify this hypothesis. We demonstrated that tumor cells continuously treated with BCLT or cultured in androgen depleted medium progressively acquire higher DNMT activity and expression. Increased DNMT expression and activity also paralleled the up-regul...

ea0029oc11.5 | Thyroid Clinical 2 | ICEECE2012

Thyroid hormones and male sexual function

Corona G. , Frederick W. , Forti G. , Lee D. , O'Connor D. , O'Neill T. , Pendleton N. , Bartfai G. , Boonen S. , Casanueva F. , Finn J. , Giwercman A. , Thang H. , Huhtaniemi I. , Kula K. , Lean M. , Punab M. , Vanderschueren D. , Jannini E. , Mannucci E. , Maggi M.

Objective: The role of thyroid hormones in the control of erectile functioning has been only marginally investigated. The aim of this study is to investigate the association between thyroid and erectile function in a general population sample (European Male Aging study, EMAS study) and in patients seeking medical care for sexual dysfunction (University of Florence Study, UNIFI study).Participants: Two different cohorts of subjects were evaluated. The fir...