Searchable abstracts of presentations at key conferences in endocrinology

ea0063p1161 | Thyroid 3 | ECE2019

Do patients with differentiated thyroid cancer (DTC) harboring TERT promoter mutation require a more intensive treatment and follow-up? – proposal of a prospective study

Samborski Konrad , Krajewska Jolanta , Rusinek Dagmara , Oczko-Wojciechowska Magdalena , Jarzęb Barbara

Introduction: The importance of telomerase reverse transcriptase promoter (TERTp) mutations in DTC is widely discussed. It has been demonstrated that the presence of TERTp mutations is associated with higher cancer aggressiveness, reflected by lymph node metastases, distant metastases, advanced tumor stage, recurrence, and even disease-specific mortality. Nevertheless, there is no clear evidence-based data demonstrating how to manage these patients. Therefore...

ea0070ep2 | Adrenal and Cardiovascular Endocrinology | ECE2020

Pregnancy during adjuvant mitotane therapy because of adrenocortical carcinoma – case report

Stępiński Kamil , Jurecka-Lubieniecka Beata , Michalik Barbara , Gorki Karolina , Jarząb Barbara

Introduction: Primary adrenocortical carcinoma (ACC) is a highly malignant but rare neoplasm. It can occur as a hormonally active or an inactive tumor. It is considered that about three-fourths of ACC cases are hormonally active, although they do not always give clinical symptoms. Mitotane (Lysodren) is registered by the FDA for the therapy of ACC, either for monotherapy or as a combined chemotherapy.Case report: A 34-year-old woman, with a histopatholog...

ea0063ep8 | Adrenal and Neuroendocrine Tumours | ECE2019

Characteristics of factors affecting the survival of patients with adrenal cortical carcinoma treated with mitotane

Stępiński Kamil , Jurecka-Lubieniecka Beata , Michalik Barbara , Kotecka-Blicharz Agnieszka , Gawlik Tomasz , Soczomski Przemysław , Jarzęb Barbara

Introduction: Adrenal cortical carcinoma (ACC) is a rare malignant neoplasm of epithelial origin, derived from the adrenal cortex, with a high tendency to local invasion and distant metastases.Aim: The aim was to assess the effect of serum mitotane concentration during mitotane therapy and identify prognostic factors on the survival of ACC patients.Material and methods: It was a multifactorial analysis of patients from a single end...

ea0063p421 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

RET Y791F carriers’ medical history – experience from one center

Hasse-Lazar Kornelia , Kotecka-Blicharz Agnieszka , Oczko-Wojciechowska Małgorzata , Pawlaczek Agnieszka , Michalik Barbara , Gawlik Tomasz , Jurecka-Lubieniecka Beata , Krajewska Jolanta , Krol Aleksandra , Legutko Marta , Czarniecka Agnieszka , Zeman Marcin , Jarzęb Barbara

Introduction: Germline mutations of RET oncogene result in development of multiple endocrine neoplasia type 2 (MEN 2). There is a strong correlation between type of the RET sequence changes and the aggressiveness of main syndrome feature, medullary thyroid carcinoma (MTC), and the incidence of remaining manifestations, mainly pheochromocytoma (PHEO). For many of the RET germline mutations, the clinical risk have been precisely defined, but there are ...

ea0040p6 | (1) | ESEBEC2016

Toxicity of tyrosine kinase inhibitors in the treatment of thyroid cancer – a 10-year experience resume

Krajewska Jolanta , Kukulska Aleksandra , Paliczka-Cieślik Ewa , Handkiewicz-Junak Daria , Gawlik Tomasz , Olczyk Tomasz , Kropińska Aleksandra , Michalik Barbara , Gubała Elżbieta , Jarząb Barbara

Targeted therapy based on tyrosine kinase inhibitors (TKIs) constitutes a new treatment modality in thyroid cancer (TC). Their efficacy in prolongation of progression free survival in comparison to placebo has been documented in phase III studies. However, a problem of their tolerability has recently risen as numerous side effects influencing the quality of life may potentially limit their clinical use. Therefore, we decided to carry out a retrospective analysis of the frequen...

ea0099ep268 | Pituitary and Neuroendocrinology | ECE2024

Assessment of the effects of empty or partially empty sella on optic chiasm compression and displacement

Kaluza Bernadetta , Mariusz Furmanek , Jan Domański , Aleksandra Żuk-Łapan , Emilia Babula , Iga Poprawa , Małgorzata Landowska , Karolina Jarząbek , Justyna Popczyńska , Paulina Filipowicz , Małgorzata Wielglewska , Jerzy Walecki , Edward Franek

Herniation of the subarachnoid space into the sella turcica results in empty or partially empty sella syndrome. Primary sella turcica syndrome is idiopathic, whereas secondary empty sella is a result of central nervous system pathologies, which may manifest as visual disorders, due to optic chiasm compression or displacement. The purpose of this study was to determine whether empty and partially empty sella—either primary or secondary—are risk factors for optic chias...

ea0040p7 | (1) | ESEBEC2016

The genetic screening of RET proto-oncogene in Polish population during the past two decades

Oczko-Wojciechowska Małgorzata , Sromek Maria , Pawlaczek Agnieszka , Czetwertyńska Małgorzata , Kula Dorota , Żebracka-Gala Jadwiga , Rusinek Dagmara , Kowal Monika , Gubała Elżbieta , Szpak-Ulczok Sylwia , Gawlik Tomasz , Zub Renata , Tyszkiewicz Tomasz , Cyplińska Renata , Hasse-Lazar Kornelia , Wygoda Zbigniew , Krajewska Jolanta , Wiench Małgorzata , Dedecjus Marek , Jarzęb Barbara

Introduction: Gain of function mutations of RET protooncogene are associated with hereditary medullary thyrpoid cancer. There are mainly specific hot-spot RET gene mutations however they may differ between population.Aim of the study: In this study we report the prevalence of RET mutations in Polish population based on 20 years of experience of referral polish centers.Material and methods: RET ge...