Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep105 | Adrenal and Cardiovascular Endocrinology | ECE2022

Serum cortisol immunoassay performance in the overnight dexamethasone suppression test.

Atkins Jonathan , Owen Laura , Clayton Jonathan , Hawley James M , Scargill Jonathan , Keevil Brian

Background: The 1 mg overnight dexamethasone suppression test (ONDST) is recommended for the differential diagnosis of CushingÂ’s syndrome and the investigation of adrenal incidentalomas. However, diagnostic performance of the test relies on accurate methods to quantitate cortisol in serum. Although the variable performance of serum cortisol immunoassays has been well-documented, little has been published on their performance following the ONDST.Aims...

ea0086p75 | Metabolism, Obesity and Diabetes | SFEBES2022

Health Inequality and its link to HbA1c Test Recovery in a Developed Health Economy: In a ‘Nearly Post COVID-19’ World

Heald Adrian , Holland David , Duff Christopher J , Scargill Jonathan , Hanna Fahmy , Fryer Anthony

Background: We previously showed that in first 6 months of the UK Covid-19(C19) pandemic >6.6million HbA1c tests were missed, including 1.4million in people with diabetes(DM). Furthermore, C19 more significantly impacts people with DM / socioeconomically disadvantaged individuals.Aim: To examine variability in recovery rate of HbA1c testing, and links to demographics, including deprivation status.Methods: We examined HbA1c test...

ea0036P82 | (1) | BSPED2014

An audit to assess the impact of increasing the borderline blood spot TSH cut-off on the detection of cases of congenital hypothyroidism (CHT) identified via newborn screening

Tetlow Lesley , Ehtisham Sarah , Hird Beverly , Manfredonia Claire , Nice Daniella , Scargill Jonathan , Steele Caroline

Background: The UK Newborn Screening Programme Centre Clinical Referral Standards and Guidelines for CHT (2013) define TSH cut-offs for screen positive (>20 mU/l) and borderline (>10 and <20 mU/l) results. In Manchester levels >8 and <20 mU/l are classified as borderline. This audit aims to assess whether adopting the national cut-off would result in babies with significant and permanent hypothyroid disease being missed.Patient popula...

ea0077p64 | Metabolism, Obesity and Diabetes | SFEBES2021

The Variability In Glycosylated Haemoglobin (HbA1c) Testing Interval In People With Diabetes Is Linked To Long-Term Diabetes Control, Independent of HbA1c Test Interval

Heald Adrian , Holland David , Stedman Michael , Duff Chirstopher J , Green Lewis , Scargill Jonathan , Hanna Fahmy WF , Wu Pensee , Fryer Anthony A

Introduction: Worldwide guidance advocates regular HbA1c testing for people with diabetes mellitus, usually 2-4/yr. We previously showed that HbA1c testing frequency is linked to outcome in terms of HbA1c control. Here we examine the effect of variability (standard deviation = SD) in test interval on change in HbA1c over 7 yrs (Jun 2012-Jul 2019) using laboratory data.Methods: We focused on people with HbA1c within the first 2 years who also had a HbA1c ...

ea0065p28 | Adrenal and Cardiovascular | SFEBES2019

Recalibration of thinking about adrenocortical function assessment: How the random cortisol relates to the short Synacthen test ‘Verdict’

Michaelidou Maria , Yadegarfar Ghasem , Robinson Adam , Naseem Asma , Khan Inamullah , Kochhar Rupinder , Scargill Jonathan , Trainer Peter , Heald Adrian

Background: The short synacthen test (SST) is the most commonly performed investigation to assess for suspected adrenocortical dysfunction. We investigated how random cortisol levels may relate to pass/fail on the STT.Methods: We analysed the relation between random cortisol measurements taken between 04.40 and 20.52 in the day and results of SST baseline and 30/60 min cortisol performed over a 12 month period (338 SSTs) at Salford Royal Hospital. Serum ...