Searchable abstracts of presentations at key conferences in endocrinology

ea0085oc5.7 | Oral Communications 5 | BSPED2022

Salivary cortisol and cortisone in healthy children and young people

Dliso Silothabo , Park Julie , Jones Lily , Bright Orla , Shantsila Alena , Hawcutt Daniel , Lip Gregory , Blair Joanne

Background: Cortisol is inactivated to cortisone in the salivary gland by 11β-HSD type 2. Concentrations of cortisone and cortisone in saliva correlate strongly with serum cortisol concentrations (1). Only free, biologically active hormone is measured in saliva, testing is non-invasive and can be performed at home/school, reducing cost and inconvenience to families and NHS resources. We previously reported pilot data from healthy children and young people (CYP) (1). Here we de...

ea0085p3 | Adrenal 1 | BSPED2022

Mean glucose concentrations are increased, and cardiovascular risk factors are common in children and young people with secondary adrenal insufficiency (GRACE2)

Park Julie , Jones Lily , Dliso Silothabo , Hawcutt Daniel , Shantsila Alena , Lip Gregory , Blair Joanne

Background: Hypoglycaemia, possibly due to non-physiological hormone replacement, and poor cardiovascular outcomes are described in patients with adrenal insufficiency (AI), particularly in the adult population. In this study, we describe glucose profiles and risk factors for premature cardiovascular disease (CVD) in children with secondary AI (SAI).Methods: Participants underwent continuous glucose monitoring (CGM), for seven days (blinded Dexcom G6 mon...

ea0023p36 | (1) | BSPED2009

What do young people think about seeing the doctor alone in paediatric endocrine clinics?

Gleeson Helena , O'Shea Elaine , Jones Julie , Patel Leena , Hall Catherine , Banerjee Indi , Amin Rakesh , Clayton Peter

Background: Seeing the doctor alone has been associated with a better outcome following transition to adult services.Methods: A simple questionnaire was designed for young people (YP) to enquire about being seen alone in paediatric endocrine clinics.Results: The questionnaire was administered to 72 YP young people (37 male) with long term endocrine conditions. The mean age was 15.5 (2.5). 10% of YP thought they should be offered th...

ea0056p358 | Diabetes (to include epidemiology, pathophysiology) | ECE2018

Think insulin: a prospective study of the knowledge of insulin preparations and administration in a Cohort of nurses in district general hospital

Jade Shepherd Emma , Ashotush Surya , Jones Sian , Jones Julie , Mumford Beth , Harrison Gaynor , Abusahmin Hussam

Introduction: Blood glucose control in insulin-dependent diabetes is heavily influenced by compliance, and how insulin is administered, which is emphasised to those with diabetes. However, when a patient is admitted to hospital, the administration of insulin is often by a nurse. The aim of this study was therefore to assess the knowledge of nurses around this subject, and to identify if there was a need for further training.Method: We conducted a prospec...

ea0085p2 | Adrenal 1 | BSPED2022

Salivary adrenal biomarkers differ depending on age and sex in healthy children: preliminary data

Park Julie , Jones Lily , Dliso Silothabo , Bright Orla , Walker Laura , Grasim Ionela , Hawcutt Daniel , Shantsila Alena , Lip Gregory , Blair Joanne

Background: Saliva is ideal for measuring free, biologically active hormones. Measurements of salivary androgens may be valuable in diagnosis and monitoring of adrenal disorders, however the diurnal profile and robust reference ranges in healthy children are currently undefined. We report salivary testosterone, androstenedione (A4), 11-ketotestosterone (11-KT), 11-β hydroxyandrostenedione (11β-OHA4) concentrations measured throughout the day in healthy children.<...

ea0033p7 | (1) | BSPED2013

Audit on the characteristics and management of patients in a large tertiary hospital paediatric adrenal clinic

Knox Ailie , Ehtisham Sarah , Clayton Peter , Jones Julie , O'Shea Elaine , Patel Leena , Skae Mars , Banerjee Indie , Padidela Raja

Adrenal insufficiency (Adr-I) and congenital adrenal hyperplasia (CAH) are important conditions requiring specialist attention and management. Recent CAH genotype–phenotype studies have linked mutations with enzyme functioning and disease severity. Accurate diagnosis for the cause of adrenal insufficiency and the genetic cause of CAH is vital as it impacts management and prognosis.Methods: We audited patients with Adr-I and CAH seen in outpatients f...

ea0030p33 | (1) | BSPED2012

Karyotype-phenotype correlations in height and pubertal outcomes of Turners patients

Page Angela , O'Shea Elaine , Jones Julie , Banerjee Indi , Padidela Raja , Amin Rakesh , Skae Mars , Patel Leena , Clayton Peter , Ehtisham Sarah

Introduction: Turner syndrome (TS) is caused by the absence of all or some of the second sex chromosome. Consequences include short stature and ovarian failure. This study aimed to characterise karyotype-phenotype correlation in patients with TS.Methods: This was a retrospective audit of TS patients from the young person’s endocrine clinic (YPC). The karyotype, final height, pubertal progress and treatment were recorded for each patient and outcomes...

ea0030p58 | (1) | BSPED2012

Key efficacy issues in the use of recombinant human GH in children with prader–willi syndrome

Thornton Mary , Banerjee Indi , Padidela Raja , O'Shea Elaine , Jones Julie , Amin Rakesh , Patel Leena , Ehtisham Sarah , Clayton Peter , Skae Mars

Prader-Willi syndrome (PWS) is a rare genetic condition characterised by hypotonia, early feeding difficulties, hyperphagic obesity, hypogonadism and short stature; with an incidence between 1/15 000 and 1/25 000 live births in the UK. It is caused by failed expression of paternally inherited genes in the imprinting region of chromosome 15q11.2–q13. Recombinant human GH (rhGH) is the main pharmacological treatment used in PWS.Aims: We aimed to revie...

ea0023p34 | (1) | BSPED2009

What skills do young people attending paediatric endocrine clinics feel they need before transfer to adult services?

Yohananthan Keerthiga , Jones Julie , O'Shea Elaine , Amin Rakesh , Banerjee Indi , Hall Catherine , Patel Leena , Clayton Peter , Gleeson Helena

Background: A key element of the transition process is encouraging young people (YP) to become more independent in their healthcare. However it is not known what skills YP feel they need before being ready for transfer to adult services.Method: A simple questionnaire was designed for YP to rate out of 5 A. their current status in terms of 5 aspects of independence in healthcare (5 “yes, I do it all of the time” to 1 “no, my family does it ...

ea0019p320 | Steroids | SFEBES2009

Sexual dichotomy in long term growth trajectories of children with 21-hydroxylase deficiency congenital adrenal hyperplasia (CAH)

Chandrasekhar Sudha , Patel Leena , Gemmell Islay , Amin Rakesh , Banerjee Indi , Hall Catherine , Jones Julie , O'Shea Elaine , Clayton Peter

Objective: To evaluate longitudinal growth in 21-hydroxylase deficiency CAH, factors contributing to this and outcome for BMI, weight (Wt) and height (Ht) in adolescence.Methods: Multi-level longitudinal models were used to evaluate growth patterns of 28 males and 29 females with CAH. Age at adiposity rebound was derived from the roots of the fitted curves and compared to UK 1990 references. The influence of hydrocortisone (HC) and fludrocortisone (FC) d...