Endocrine Abstracts

: 39Y old male who was originally treated as child with CAH secondary to 21-Hydroxylase deficiency and was put on glucocorticoids and mineralocorticoids from first week of life due to salt wasting crises. He has had very high 17-OH progesterone and adrenal androgen due to noncompliance. He developed polycythemia secondary to androgen excess, resulted in venesection. Haematologist have investigated the mutation and EPO measurement and he felt that this was probably secondary po...

After diabetes, thyroid disorder is the second most common endocrine disorder in women of reproductive age. Thyroid disorders in pregnancy have been proven to have adverse maternal and foetal outcome if not treated adequately and timely.Aim: The aim of this audit was to assess management and therapeutic interventions and outcomes of pregnancies complicated by thyroid disorders.Method: A retrospective case notes analysis of 35 pregn...

After diabetes, thyroid disorder is the second most common endocrine disorder in women of reproductive age. Thyroid disorders in pregnancy have been proven to have adverse maternal and foetal outcome if not treated adequately and timely.Aim: The aim of this audit was to assess management and therapeutic interventions and outcomes of pregnancies complicated by thyroid disorders.Method: A retrospective case notes analysis of 35 pregn...

44 years old lady was referred to Endocrinology Clinic with history of secondary amenorrhea and hyperprolactinaemia (7800), that responded to Cabergolin treatment, which was discontinued after 2 months due to side effects (headaches). There was no galactorrhea or visual field defects. MRI Pituitary initially reported as Empty Sella. Her prolactin levels rose further along with headach after she discontinued Cabergoline (and refused alternatives). She eventually agreed for nigh...

Background: Treating life-threatening diabetic ketoacidosis (DKA) with a pH of <6.9 is extremely challenging and often refractory to treatment using standard fixed dose insulin DKA management protocols which may not work effectively at this low pH because of increased insulin resistance. I.v. bicarbonate (HCO3) use in this situation can be considered but remains controversial due to the risk of significant side effects as well as limited evidence in literature. ...

A 37-year-old Asian lady was diagnosed with T3 N1b Papillary carcinoma of the thyroid and operated in 1999. Post operatively she developed hypoparathyroidism and has been on regular calcium and thyroid hormone replacement.She was on her 5th pregnancy this year. She had 2 previous Caesarian sections and 1 normal vaginal delivery. She was referred to Good Hope Hospital for obstetric care & local tertiary centre for investigation of hypocalcaemia having...

Ovarian hyperthecosis is a rare cause of androgenic alopecia in postmenopausal women. The physiological levels of androgens, secreted by ovarian stromal cells, are greatly increased with hyperplastic or neoplastic transformation leading to possible clinical consequences.We report a case of a 56-year-old woman with type 2 diabetes presenting with hirsuitism and a history of male pattern hair loss over a two year period. Biochemistry showed elevated levels...

Case history: A 34-year old Caucasian nurse presented to her GP with a 7 month history of abdominal pain. She was found to have PTH-dependent hypercalcaemia with Stage 3A chronic kidney disease (corrected calcium 3.43 mmol/l, phosphate 0.62 mmol/l, total vitamin D 32 nmol/l, PTH 214.9 pmol/l, creatinine 117 μmol/l and eGFR 45 ml/min/1.73m2). On direct questioning, she reported fatigue, generalised weakness and intermittent joint pains affecting her lower back and bo...