Endocrine Abstracts

Personalized medicine is a crucial part of modern medicine. As a result, other therapeutic options apart from levothyroxine are considered when treating hypothyroidism. Desiccated thyroid pharmaceuticals, that in addition to thyroxine (T4), contain triiodothyronine (T3), are one of them. ETA recognized the rapid use of desiccated thyroid pharmaceuticals and described specific guidelines for its utilization. The biggest problem of their use is unresolved issues of content that ...

The cholesterol oxidation product 27-hydroxycholesterol (27OHC) is enzymatically produced from cholesterol by CYP27A1 in an alternative pathway of cholesterol degradation to bile acids. This oxysterol also acts as an endogenous selective estrogen receptor modulator (SERM). In healthy humans its concentration in circulation increases in hypercholesterolemia and with age, and is associated with increased risk of atherosclerosis, cardiovascular diseases and breast cancer. Several...