Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep41 | Adrenal cortex | ECE2015

Effect of stress-dosed hydrocortisone on physical capacity in patients with Addison's disease

Simunkova Katerina , Jovanovic Nevena , Oksnes Marianne , Lovas Kristian , Husebye Eystein Sverre

The current conventional glucocorticoid (GC) replacement therapy in primary adrenal insufficiency (Addison’s disease) and congenital adrenal hyperplasia (CAH) renders the cortisol levels unphysiological, resulting in very high levels alternating with almost undetectable levels of cortisol over the day. This reduces not merely the patient’s quality of life but increases the patient’s morbidity and mortality. The HPA axis is characterised by a dynamic circadian va...

ea0037ep1350 | Endocrine nursing | ECE2015

Continuous subcutaneous hydocortisone infusion replacement treatement in adrenal insufficiency – how to start the hydrocortisone infusion

Simunkova Katerina , Jovanovic Nevena , Rostrup Espen , Methlie Paal , Oksnes Marianne , Nilsen Roy Miodini , Henno Hanne , Tilseth Mira , Godang Kristin , Kovac Ana , Lovas Kristian , Husebye Eystein Sverre

Many patients with primary adrenal insufficiency (Addison’s disease) take extra doses of glucocorticoids before or during stressful events, but benefit has not been demonstrated. We aimed to test the effect of an extra dose of glucocorticoids on cardiorespiratory, hormonal and metabolic parameters in response to physical activity in a randomised placebo-controlled, 2-weeks cross-over, clinical trial ( NTC01847690). Ten women with Addison’s disease a...

ea0070aep69 | Adrenal and Cardiovascular Endocrinology | ECE2020

Pulsatile subcutaneous hydrocortisone replacement in primary adrenal failure, a proof of concept pilot trial

Simunkova Katerina , Øksnes Marianne , Methlie Paal , Jovanovic Nevena , Selemon Gebreslase Nebeyaet , Løvås Kristian , Sverre Husebye Eystein

Background: The pulsatile endogenous cortisol secretion is crucial for ultradian rhythmicity in blood and this rhythmicity triggers pulses of gene signaling in tissues. Disturbances in cortisol pulsatility can lead to cognitive, metabolic and cardiovascular dysfunction, and could explain why patients with primary adrenal insufficiency on conventional glucocorticoid replacement have reduced quality of life, increased mortality and are at risk of cardiovascular complications. Pu...