Searchable abstracts of presentations at key conferences in endocrinology

ea0035p567 | Endocrine tumours and neoplasia | ECE2014

Neuroendocrine carcinomas of the thymus: two case reports

Sepp Krisztian , Csajbok Eva , Magony Sandor , Julesz Janos , Valkusz Zsuzsanna

The neuroendocrine tumor of thymus (TNET) is an extremely rare disease. It can occur sporadically or as a part of the multiple endocrine neoplasia (MEN1) syndrome. TNET may secret hormons (ectopic ACTH production). It is a potentially malignant tumor which often develops distant metastases. Its prognostic factors are the tumor size, histological grade, Ki67 index, paraneoplastic symptoms, surgical resection and Masaoka staging. The options for treatment are radical surgery, ch...

ea0022p216 | Clinical case reports and clinical practice | ECE2010

10 years experience with somatostatin analogue (SSA) treatment in multiple endocrin neoplasia type 1 (a case report)

Krisztian Sepp , Zsuzsanna Valkusz , Ildiko Kiss , Laszlo Pavics , Janos Julesz

Multiple endocrine neoplasia (MEN-1) is a rare congenital disease with genetic background. The MEN-1 gene encodes the menin protein, which acts as a tumour suppressor. Mutation of one allele and the inactivation of the other allele of this gene lead to clonal proliferation and to the development of tumours. The clinical manifestation of MEN-1 is a combination of endocrine (most commonly parathyreoid adenomas, entero-pancreatic endocrine tumours, pituitary tumours) and non-endo...

ea0022p250 | Clinical case reports and clinical practice | ECE2010

Different manifestations of polyglandular autoimmune syndrome in HLA-identical monozygous twins

Csajbok Eva , Magony Sandor , Valkusz Zsuzsanna , Panczel Pal , Julesz Janos

The polyglandular autoimmune syndromes (PAS) comprise a wide spectrum of autoimmune disorders and are divided into a very rare juvenile (type I) and a relatively common adult type with (type II) or without adrenal failure (PAS III). For PAS II/III, susceptibility genes are known inreasing the risk for developing autoimmune disorders, but without being causative. Actual diagnosis of PAS involves serological measurement of organ-specific autoantibodies and subsequent functional ...

ea0032p570 | Endocrine tumours and neoplasia | ECE2013

Various neuroendocrine tumors in a multiple endocrin neoplasia type 1 family with the same genetic background

Sepp Krisztian , Csajbok Eva , Magony Sandor , Julesz Janos , Patocs Attila , Racz Karoly , Valkusz Zsuzsanna

Introduction: Multiple endocrine neoplasia (MEN) type 1 is a rare congenital disease with genetic background. The MEN-1 gene encodes menin protein, that acts as a tumor suppressor. Mutation of one allele and the inactivation of the other allele of this gene lead to clonal proliferation and to the development of tumors. The clinical manifestation of MEN type 1 is a combination of endocrine (parathyroid adenomas, entero-pancreatic neuroendocrine tumors, pituitary tumors) and non...

ea0022p31 | Adrenal | ECE2010

Adrenocortical cancer: any hope? case reports

Valkusz Zsuzsanna , Magony Sandor , Csajbok Eva , Gardi Janos , Kiss Ildiko , Julesz Janos

Adrenocortical cancer is a rare and heterogenous malignancy with incompletely understood pathogenesis and poor prognosis. Sometimes patients present with hormonal excess symptoms (e.g. virilization, CushingÂ’s syndrome) or local symptoms consistent with abdominal space-occupation (median tumor size at the time of diagnosis may be >10 cm). Three cases are presented to give an overview of how adrenocortical cancer is currently managed. Tumors typically appear inhomogenou...