Endocrine tumours and neoplasia

Pituitary tumorigenesis has been analysed from multiple perspectives, yet mRNA expression profiling studies are limited. In this study, microarray analysis was used to identify pathways and networks related to pituitary tumour physiology using key de-regulated genes and bioinformatics analysis. Eight pituitary adenomas (five non-functional tumours, two GH-secreting tumours and a TSH/prolactin-secreting tumour) and a pool of random normal control RNA were profiled for RNA expre...

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ea0035p515 | Endocrine tumours and neoplasia | ECE2014

Our experience in the evaluation criteria used for the genetic study of patients suspected of being affected by multiple endocrine neoplasia type 1 and mutational spectrum

Oriola Josep , Sitges Antoni , Goday Albert , Martinez S , Villabona Carles , Gomez Jose Manuel , Loidi Lourdes , Salinas Isabel , Puig-Domingo Manel , Gonzalez-Romero E , Garcia-Arnes J A , Lecube Albert , Mesa Jordi , Simo Rafael , Rosell J , Sanchez-Garcia F , Recas Immaculada , Biarnes Josefina , Pizarro Eduarda , Halperin Irene

Introduction: The autosomal dominant multiple endocrine neoplasia type 1 (MEN1), characterized by parathyroid hyperplasia (PH), neuroendocrine digestive tumours (NET) and pituitary adenomas (PA), is due to mutations in the tumor suppressor gene MEN1 encoding a 610-amino acid protein, menin. Guidelines recommend MEN1 mutational analysis in index cases with two or more MEN1-associated tumours, in first-degree relatives of mutation carriers and when clinical dat...

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ea0035p516 | Endocrine tumours and neoplasia | ECE2014

The truncated somatostatin receptor sst5TMD4 stimulates the production of pro-angiogenic factors in in vitro and in vivo breast cancer models

Luque Raul M , Duran-Prado Mario , Rincon-Fernandez David , Hergueta-Redondo Marta , Culler Michael D , Moreno-Bueno Gema , Gahete Manuel D , Castano Justo P

The presence of the truncated somatostatin receptor sst5TMD4 has been correlated with poor prognosis in breast cancer tumorsand its overexpression in breast cancer derived cell lines is associated with increased cell malignancy. The objective of this study was to examine the cellular and molecular mechanisms underlying this association in order to identify new molecular targets for diagnosis, prognosis or therapy of these tumors. Accordingly, in this study, a breast cancer der...

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ea0035p517 | Endocrine tumours and neoplasia | ECE2014

The effects of cAMP in different neuroendocrine tumorous cells: the role of Epac and PKA in cell proliferation and cell adhesion

Vitali Eleonora , Cambiaghi Valeria , Zerbi Alessandro , Peverelli Erika , Mantovani Giovanna , Loiarro Federica , Carnaghi Carlo , Spada Anna , Lania Andrea

cAMP is an ubiquitous second messenger that is implicated in the regulation of a wide variety of cell functions, including cell proliferation that is differently affected depending on the cell type. Although the effects exerted by cAMP were initially attributed to PKA activation, two exchange proteins directly activated by cAMP (Epac1/2) have been identified as cAMP targets able to mediate several cAMP effects. Aim of this study was to investigate the effect of cAMP on neuroen...

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ea0035p518 | Endocrine tumours and neoplasia | ECE2014

Molecular mechanisms of unexpected promoting effects of progesterone and mifepristone on granulosa cell tumorigenesis

Ponikwicka-Tyszko Donata , Chrusciel Marcin , Stelmaszewska Joanna , Bernaczyk Piotr , Li Xiangdong , Huhtaniemi Ilpo , Wolczynski Slawomir , Rahman Nafis A

Antiprogestine mifepristone (MF) has been shown to inhibit ovarian epithelial cancer (OEC) cell growth in vitro and in vivo. Recent clinical trials with MF for human OEC were unsuccessful, for unknown reasons. Progesterone (P4) is believed to have preventive measures towards breast, endometrial or hOEC cancers. Hereby we analyzed the effects of P4 and MF on ovarian granulosa cell tumorigenesis (GCT) in vitro and in vivo...

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ea0035p519 | Endocrine tumours and neoplasia | ECE2014

BRAF V600E mutation in washing liquid of thyroid fine-needle aspiration: a surprising tool in cytological benign nodules

Monzani Maria Laura , Brigante Giulia , Marino Marco , Bonacini Lara , Pignatti Elisa , Cioni Katia , Madeo Bruno , Rochira Vincenzo , Santi Daniele , Maiorana Antonino , Carani Cesare , Simoni Manuela

Objective: Thyroid fine-needle aspiration (FNA) cytology is indeterminate in 1525% of cases. Recently, cytological analysis was combined to molecular analysis to improve diagnostic accuracy. In the present study, washing liquid of FNA (wFNA) samples were tested for the BRAF V600E mutation, using high resolution melting (HRM) technology. The aim of this study was to demonstrate whether BRAF mutation analysis is accurate in wFNA and, when combined with cytological analysis...

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ea0035p520 | Endocrine tumours and neoplasia | ECE2014

Classic ductal sonographic criteria vs real-time elastography criteria in diagnosing nodular breast lesions

Stoian Dana , Ionac Mihai , Craciunescu Mihaela , Craina Marius

Objectives: We evaluated the diagnostic power of different used evaluation criteria in ultrasound 2B, Doppler and elastography.Method: Retrospective data analyses of all cases with breast lumps, that were evaluated and also operated during the study follow-up period. Study period: January 2011April 2013 (Table 1).Ductal breast ultrasound, Doppler and real-time elastography was performed with a HITACHI EUB 7500 HV machine, wit...

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ea0035p521 | Endocrine tumours and neoplasia | ECE2014

A case of insulinoma localized in pancreas tail that cannot be monitored with endosonography and abdominal MR but with contrast abdominal BT

Kutbay Nilufer Ozdemir , Ocek Levent , Nart Deniz , Erdogan Mehmet , Cetinkalp Sevki , Ozgen A Gokhan , Saygili Fusun

Introduction: Insulinoma is a rare neuroendocrine tumor. 90% of insulinoma is solitaire and benign, and 10% is malignant. Although seen at any age, it is most commonly noticed in 4th and 6th decades.Case: A 78-year-old man was referred to a neurology clinic upon a sudden faint, disability to remember and meaningless behavior, and diagnosed with epilepsy in 2008. In 2012, he had a hypoglycemia attack (blood glucose 30 mg/dl) and was referred to Ege Univer...

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ea0035p522 | Endocrine tumours and neoplasia | ECE2014

Adrenocortical carcinoma: a review of four cases

Kocak Mustafa , Ucuncu Ozge , Civan Nadim , Coskun Hulya , Turkyilmaz Serdar , Ersoz Halil Onder , Erem Cihangir

Background: Adrenal carcinoma is rare endocrine cancer. Survival time is short and primary treatment is surgery.Methods: Four patients with histopathologically diagnosed as adrenal carcinoma between 2007 and 2013 were evaluated retrospectively.Results: Two of the patients were female and others were male. Their ages were 39, 50, 55 and 61 respectively. All the patients were admitted to the hospital with abdominal pain. Tumor diamet...

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ea0035p523 | Endocrine tumours and neoplasia | ECE2014

A rare case of an androgen-producing stromal luteoma of the ovary in a postmenopausal woman, diagnosed by means of selective venous blood sampling

Bogdanou Dimitra , Meyer Gesine , Stucker Anja-Undine , Hansmann Martin-Leo , Thalhammer Axel , Bojunga Jorg

Background: Multiple diagnostic modalities may be needed to establish the source of excessive androgen production in women. The detection of testosterone-producing ovarian tumors by imaging techniques can be difficult because of their in same cases small size and radiological structure.Case report: We describe a 55-year-old postmenopausal woman presenting with progressive severe virilization (Ferriman Gallwey-Score: 2326), increased hair growth, ma...

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ea0035p524 | Endocrine tumours and neoplasia | ECE2014

Fnab and calcitonin wash-out during exenatide therapy

Taskiran Bengur

Aim: Medullary thyroid cancer (MTC) is 4.73 times higher among glucagon-like peptide-1 (GLP-1) agonist users. GLP-1 agonists are witheld in case of MTC or MEN. Serum calcitonin (Ct) does not increase to diagnostic level in small and nonmetastatic MTC. We report cytology and Ct wash-out results of fine-needle aspiration biopsy of thyroid nodules (FNAB) in type 2 diabetic patients receiving exenatide.Methods: Eleven male and 66 female patients (3176 ...

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ea0035p525 | Endocrine tumours and neoplasia | ECE2014

The presence of B-RAF V600E and K601E mutations in our Ligurian population

Eleonora Monti , Lorenzo Mortara , Simonetta Zupo , Gianluca Ansaldo , Mauro Truni , Francesco Minuto , Massimo Giusti

Introduction: Differentiated thyroid carcinoma (DTC) is the most common endocrine neoplasm and its rate its constantly increasing. Papillary thyroid carcinoma (PTC) represents 87% of all DTC and its incidence is raising at 89%. The thyroid carcinoma preoperative diagnosis consists in fine-needle ago aspiration (FNAB). However in the diagnostic cytology there actually is a grey zone, the follicular lesion of indeterminate significant or suspicious for fo...

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ea0035p526 | Endocrine tumours and neoplasia | ECE2014

The use of demeclocyclin in the syndrome of paraneoplastic inappropriated secretion of anti-diuretic hormone: about one observation

Garcia Cyril , Poncin Thibault , Legarlantezec Patrick , Bordier Lyse , Mayaudon Herve , Dupuy Olivier , Cremades Serge

Introduction: Hyponatraemia constitutes the most common hydro-electrolytic abnormality and the determination of its cause is important for patients treatment, which can include the use of a pharmacological agent.Observation: A 78-year-old woman suffering from a lung adenocarcinoma presents a chronic hyponatraemia ranging from 114 to 123 mmol/l, which cannot be corrected by fluid limitation alone. Clinical and biological assessment leads to diagnose...

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ea0035p527 | Endocrine tumours and neoplasia | ECE2014

Could non-functional adrenal incidentaloma be a risk factor for atherosclerosis and metabolic disturbances?

Emral Rifat , Kose Ayla Demir , Corapcioglu Demet , Demir Ozgur , Uysal Ali Riza

Introduction: Non-functional adrenal incidentalomas (AI) are currently quite important since they can also cause metabolic disturbances. This study was designed to evaluate possible insulin resistance indicators and cardiovascular risk factors in patients with non-functional AI.Patients and methods: 83 patients with non-functional AI were enrolled to the study. Control group consisted of 56 patients without any adrenal lesion. Fasting blood glucose, and ...

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ea0035p528 | Endocrine tumours and neoplasia | ECE2014

Retrospective evaluation of adrenal incidentalomas in a tertiary care institution

Askitis Dimitrios , Kloos Christof , Battefeld Wilgard , Wolf Gunter , Dirsch Olaf , Mueller Ulrich Alfons

Introduction: We retrospectively evaluated all patients with adrenal tumours treated in our Department from 1.1.1999 to 1.10.2013.Patients and methods: 189 patients (110 females: 79 males, mean age of 57.5 years) were treated because of adrenal tumours. All patients underwent hormonal analysis and testing in order to check for hormonal activity. Tumours were classified according to gender, age at diagnosis, tumour localisation and size, as well as benign...

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ea0035p529 | Endocrine tumours and neoplasia | ECE2014

A rare ovarian carcinoma

Oros Sabina Elena , Rosca Roxana Irina , Paun Diana Loreta , Dumitrascu Anda Simona , Vladoiu Susana Vilma , Caragheorgheopol Andra , Stefanescu Ana Maria , Voinea Silviu , Radu Madalina Gabriela , Terzea Dana Cristina

We present a rare association of ovarian carcinoid and virilization. A 65-year-old woman presented with a 9 years history of obesity, hypertension, dyslipidemia, stable angina, evaluated ambulatory for a postmenopausal virilization syndrome and flushes, with high testosterone and 17-hydroxyprogesterone (17OHP) levels without suppression during the 2×2 mg DXM test, normal gynecological evaluations with no tumor formation involving uterus, ovaries and adrenals at the pelvic...

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ea0035p531 | Endocrine tumours and neoplasia | ECE2014

Clinical management of insulinomas: a single institution’s experience

Gul Ozen Oz , Akkurt Aysen , Cander Soner , Ugras Nesrin , Yerci Omer , Erturk Erdinc

Background: Although very rare, insulinomas are the most commonly occurring endocrine tumor of the pancreas. The aim of this study was to review the clinical presentation, diagnostic approach and management of patients with an insulinoma.Methods: 22 insulinoma patients, with an age range of 2079, were included and evaluated according to their clinical presentation, blood biochemistry, imaging studies, operative management, pathological manifestatio...

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ea0035p532 | Endocrine tumours and neoplasia | ECE2014

Comparison of chromogranin A levels in serum and plasma (EDTA2K) and the respective reference ranges in healthy males

Glinicki Piotr , Jeske Wojciech , Kapuscinska Renata , Zgliczynski Wojciech

Introduction: Chromogranin A (CgA) is a main, nonspecific marker of neuroendocrine tumours (NET). There are various commercially assays for the measurement of CgA concentration in serum or plasma. These assays differ in analytical techniques (RIA, ELISA, CLIA), have different standardization, and use different antibodies which recognize different epitopes of CgA molecule.Aim of study: Our study was designed to confirm the noted earlier differences in CgA...

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ea0035p533 | Endocrine tumours and neoplasia | ECE2014

High JAG1 expression in adrenocortical carcinomas is associated with better prognosis

Ronchi Cristina , Sbiera Silviu , Steinhauer Sonja , Scott-Wild Vanessa , Fassnacht Martin , Allolio Bruno

Background: Adrenocortical tumors consist of benign adenomas (ACA) and highly malignant carcinomas (ACC). Dysregulation of the Notch signalling pathway is implicated in several cancers with oncogenic or tumor suppressor functions. JAG1 is a Notch1 ligand of the Jagged family and a common target gene for Notch and Wnt/β catenin pathways. It has been reported that upregulated expression of JAG1 enhances cell proliferation in ACC.Material and methods: ...

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ea0035p534 | Endocrine tumours and neoplasia | ECE2014

Role of metformin on recurrence-free survival in neuroendocrine tumors

Marciello Francesca , Modica Roberta , Marotta Vincenzo , Ramundo Valeria , Prete Michela Del , Buonomano Pasqualina , Carratu Anna Chiara , de Luca di Roseto Chiara , Picillo Ester , Colao Annamaria , Faggiano Antongiulio

Introduction: Recent data suggest that metformin has antineoplastic properties in different type of cancer. Effects of metformin have never been investigated in neuroendocrine tumors (NET).We aim to determine the role of metformine on recurrence-free survival (RFS) in NET patients.Materials and methods: A retrospective analysis was conducted comparing NET patients with recent diagnosis (<3 year) of diabetes mellitus (with HbA1c...

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ea0035p535 | Endocrine tumours and neoplasia | ECE2014

Expression of inhibitor of apoptosis protein BIRC7/livin in adrenocortical tumors

Altieri Barbara , Sbiera Silviu , Steinhauer Sonja , Fassnacht Martin , Allolio Bruno , Ronchi Cristina L

Introduction: Adrenocortical tumors consist in frequent benign adenomas (ACA) and rare highly malignant carcinomas (ACC). BIRC7/livin gene, a member of the inhibitors of apoptosis family, plays an important role in tumorigenesis in a variety of malignancies. Different studies demonstrated that BIRC7 overexpression represent a risk factor for cancer development and progression. The aim of our study was to evaluate the expression of BIRC7 in normal adrenals and adrenocortical tu...

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ea0035p536 | Endocrine tumours and neoplasia | ECE2014

Aurora kinases inhibitors Vx-680, SNS314 and ZM447439 in adrenocortical tumors

Pezzani Raffaele , Rubin Beatrice , Bertazza Loris , Cicala Maria Verena , Barollo Susi , Iacobone Maurizio , Mian Caterina , Scaroni Carla , Ulisse Salvatore , Mantero Franco

Background: Adrenocortical tumors (ACT) include benign and malignant forms. Adrenocortical carcinomas (ACC) are highly malignant neoplasms with poor prognosis and strong metastatic potential. Aurora kinase family members (AK) are serine/threonine kinase involved in the regulation of mitosis. Aurora kinase A (AKA) promotes centrosome maturation and spindle assembly, while aurora kinase B (AKB) is necessary for spindle assembly checkpoint and cytokinesis.A...

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ea0035p537 | Endocrine tumours and neoplasia | ECE2014

Sunitinib induced hypocalcaemia during treatment of pancreatic neuroendocrine tumours

Alexandraki Krystallenia , Karnezis James , Kaltsatou Maria , Chatzellis Eleftherios , Tsoli Marina , Chrysochoou Maria , Boutzios Georgios , Kaltsas Gregory

Background: Although sunitinib, an oral multitargeted tyrosine kinase inhibitor of RET, VEGFR, PDGFR, c-KIT used for cancer treatment, has a reported prevalence of hypocalcemia of 35%, this has not been documented in pancreatic neuroendocrine tumour (pNETs).Methods: We present three, out of 12, patients with pNETs treated with sunitinib who developed grade 1, 2 and 4 hypocalcemia according Common Terminology Criteria for Adverse Events v3.0 (CTCAE) crite...

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ea0035p538 | Endocrine tumours and neoplasia | ECE2014

Cyclin D1 levels are involved in the resistance to m-TOR inhibitors in human bronchial carcinoids

Benfini Katiuscia , Gagliano Teresa , Gentilin Erica , Minoia Mariella , Daniela Mole , Uberti Ettore degli , Zatelli Maria Chiara

Background: Bronchial carcinoids (BC) are still orphan of medical therapy. We previously demonstrated that the typical BC human cell line NCI-H727 is sensitive to Everolimus, in terms of cell viability reduction, while the atypical human BC cell line NCI-H720 is not. However, the mechanisms underlying this phenomenon have not been fully clarified.Aim: The aim of our study is to investigate the mechanisms of resistance to mTOR inhibitors in BC cells.<...

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ea0035p539 | Endocrine tumours and neoplasia | ECE2014

Follicular lesion of undetermined significance in thyroid nodules fine needle aspiration cytology: a revision of 95 cases

Moniz Catarina , Ferreira Rute , Serra Filipa , Fonseca Ricardo , Simoes Helder , Saraiva Catarina , Vasconcelos Carlos , Saraiva Antonio

Introduction: The Atypia of Undetermined Significance/Follicular lesion of Undetermined Significance (AUS/FLUS) category of the Bethesda Classification for thyroid nodules fine needle aspiration cytology (FNAC) is reserved for specimens that contain cells with architectural and/or nuclear atypia that is not sufficient to be classified as suspicious or malignant. Our objective is to report our experience in the follow-up and outcome of patients with AUS/FLUS in thyr...

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ea0035p540 | Endocrine tumours and neoplasia | ECE2014

Monitoring of pheochromocytomas development in proto-oncogene RET mutation’s carriers

Kotecka-Blicharz Agnieszka , Jurecka-Lubieniecka Beata , Michalik Barbara , Pawlaczek Agnieszka , Oczko-Wojciechowska Malgorzata , Hasse-Lazar Kornelia , Jarzab Barbara

Proto-oncogene RET encodes a receptor tyrosine kinase. Germline point mutations of RET result in development of multiple endocrine neoplasia, type 2 (MEN 2). MEN 2 phenotype is correlated with intragene localization of germline mutation. The disease has three main subtypes, MEN 2A, MEN 2B and FMTC. Each of subtypes is associated with high risk of medullary thyroid cancer, MEN 2A and MEN 2B with 50% risk of pheochromocytoma, MEN 2A with 1530% risk of primary hyperparathyr...

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ea0035p541 | Endocrine tumours and neoplasia | ECE2014

Efficiency of ultrasound-guided percutaneous thyroid nodule biopsy among patients hospitalized in the department of internal medicine

Maciejewski Marek , Kozlowska Beata , Budzynska-Nosal Renata , Sawicka Agnieszka , Slomian Michal , Marczewski Krzysztof

Introduction: Fine needle aspiration of thyroid nodules is the most frequently performed ambulatory and recommendations for its performance are quite accurately described in the national and international guidelines. However, there is always a need to analyze the effectiveness of such proceedings.The aim of this study was to analyze such effectiveness in group of hospitalized patients.Method: The reason for hospitalization in the v...

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ea0035p542 | Endocrine tumours and neoplasia | ECE2014

Multiple endocrine neoplasia type 1 and 2: a retrospective study

Yaker Fetta , Fedala Soumeya , Chentli Farida , Kabour Samia , Ali Leila Ahmed , Chikouche Mohamed , Griene Lakhdar

Introduction: Multiple endocrine neoplasia (MEN) are rare including MEN1:association of pituitary, pancreatic and parathyroid tumors and MEN 2 regrouping NEM2a: medullary thyroid cancer (MTC), pheochromocytoma and parathyroid tumor and NEM2b with ganglioneuromas. Theyre caused by autosomal dominant mutation: MEN1 gene (MEN 1) and RET protooncogen (MEN 2).Aim: Report the phenotypic and evolutionary characteristics of MEN.Popul...

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ea0035p543 | Endocrine tumours and neoplasia | ECE2014

The prevalence of malignancy in thyroid incidentalomas in an iodine-replete area

Balas Melania , Vlad Mihaela , Golu Ioana , Amzar Daniela , Urian Ananda , Gurban Camelia , Zosin Ioana

Background: Thyroid incidentalomas are reported with increasing incidence in the last decades. The rate of malignancy in these nodules may reach 9% or higher, depending on the patients selection.Material and methods: A retrospective study was done on 429 patients with nodular goiter (issued from an iodine-replete area), admitted in the Clinic of Endocrinology, Timisoara, Romania, from January 2011 to December 2013.Results: The prev...

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ea0035p544 | Endocrine tumours and neoplasia | ECE2014

A major Endocrine Unit’s experience: the combined role of ultrasound scans and fine needle aspiration in the management of thyroid nodules

Leung Kelvin , Elsaify Wael , Madhaven Anantha

Introduction: The first-line investigation of thyroid nodules is ultrasonography. Since the introduction of fine needle aspiration cytology (FNAC) in the last 2 decades, the diagnostic accuracy of thyroid malignancy has massively improved. This study aims to examine the sensitivities of ultrasonography and FNAC respectively, evaluating our centres practice.Methods: Retrospective data were collected from ultrasound scan and FNAC reports of patients ...

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ea0035p545 | Endocrine tumours and neoplasia | ECE2014

Ultrasonography as a first-line investigation of thyroid nodule: is it still the case? An audit to examine and reflect on our practice in a regional endocrine unit

Leung Kelvin , Elsaify Wael , Madhaven Anantha

Introduction: Ultrasonography is safe, fast and radiation-free. This audit, based on the American Thyroid Association (ATA) Management Guidelines (revised in 2009), aims to establish if our regional unit meets the recommended standards of using ultrasonography to aid the management of thyroid malignancy and to make further suggestions to improve practice.Methodology: Retrospective data were collected from ultrasound scan reports of patients who had thyro...

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ea0035p546 | Endocrine tumours and neoplasia | ECE2014

Pheochromocytoma and neurofibromatosis type 1: description of case

Monteiro Ana Margarida , Alves Marta , Souto Selma , Manso Fernando , Cruz Mariana , Marques Olinda

Introduction: The pheochromocytomas are rare neuroendocrine tumors that can occur sporadically or, in about 30% of cases, in the context of family syndromes. Ten percent are malignant. Neurofibromatosis type 1 is an autosomal dominant disease that is associated with the occurrence of these tumors. Pheochromocytoma appears at 0.1 5.7% of patients with neurofibromatosis type 1, and are usually solitary and benign lesions.Clinical case: A 50-year-old ...

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ea0035p547 | Endocrine tumours and neoplasia | ECE2014

Ganglioneuroma of the adrenal gland: a case report

Monteiro Ana Margarida , Alves Marta , Souto Selma , Luis Dina , Silva Ana Isabel , Marques Olinda

Introduction: The adrenal ganglioneuroma are rare, benign and well differentiated tumors that arise from neural crest tissue. Most patients with adrenal ganglioneuroma are asymptomatic, and most of these are non-secreting tumors. They are usually found incidentally on abdominal imaging study for another reason.Case: A 53-year-old female, with a history of hypertension diagnosed at age 30, dyslipidaemia, depressive disorder and hysterectomy for uterine pr...

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ea0035p548 | Endocrine tumours and neoplasia | ECE2014

Efficacy and safety of transarterial chemoembolization of unresectable neuroendocrine liver metastases

Ognjanovic Sanja , Petakov Milan , Elezovic Valentina , Isailovic Tatjana , Macut Djuro , Popovic Bojana , Bogavac Tamara , Bozic Ivana , Ilic Dusan , Colic Momcilo , Damjanovic Svetozar

Background: Trans-catheter arterial chemoembolization (TACE) is a method of treatment of unresectable liver metastases from neuroendocrine tumours (NETs) which is effective in the control of symptoms and tumour growth.Aim: To evaluate clinical outcome: radiologic, biologic, symptomatic response and safety of TACE procedure.Method: 31 patients underwent 140 TACE procedures during 20032011. Tumour responses were measured by CT ...

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ea0035p549 | Endocrine tumours and neoplasia | ECE2014

Efficacy of lanreotide autogel in men1-related gastrinomas: a case series

Iacovazzo Donato , Lugli Francesca , Bianchi Antonio , Capoluongo Ettore , Lucci-Cordisco Emanuela , Persiani Roberto , Doglietto Giovanni Battista , Pontecorvi Alfredo , Rindi Guido , De Marinis Laura

GEP NETs, especially gastrinomas, occur in 4070% of MEN1 patients and represent the main cause of death in these patients.We aim to investigate the efficacy of lanreotide autogel (ATG) in the treatment of MEN1-related gastrinomas.We report a monocentric series of seven MEN1 patients (three M, and four F) treated with lanreotide ATG (120 mg/4 weeks) for a mean period of 62.1 months. Plasma gastrin levels have been measured at ...

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ea0035p550 | Endocrine tumours and neoplasia | ECE2014

The effectiveness of yttrium90/lutetium177-labeled somatostatin analogues treatment in functional pNETs

Michalik Barbara , Handkiewicz-Junak Daria , Hasse-Lazar Kornelia , Jarzab Barbara

Introduction: Therapy with somatostatin analouges is usually ineffective to remove hormonal symptoms in patients with functional pancreatic neuroendocrine tumors (pNET). Alternative treatment modalities, to control symptoms of excessive hormonal production, are necessary. Thus, the aim of our study was to evaluate results of radiopeptide treatment in patient with functional pNET.Materials and methods: 92 patients with pNET (49 women and 43 men, median ag...

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ea0035p551 | Endocrine tumours and neoplasia | ECE2014

Evaluation of vegf and endocan/esm-1 expression in pnets and correlation with Ki67 and prognosis

Lugli Francesca , Iacovazzo Donato , Lanza Paola , Inzani Frediano , Waure Chiara De , Rindi Guido , Marinis Laura De

Endocan has been reported as specific of endothelial tumor cells and was shown to be expressed by tip cells during angiogenesis process.The principal aims of the study are the assessment of immunohistochemical VEGF and Endocan expression in functioning and non functioning pNETs and the comparison of these markers with clinical features, Ki67 and TNM staging.We collected a total number of 79 pNETs surgical specimens for immunohistoc...

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ea0035p552 | Endocrine tumours and neoplasia | ECE2014

Insulinoma, recurrent hypoglycaemia: a debilitating condition

Hussain Shazia , Abdin Ayman , Hawkins Anna , Casey Edel , Nikookam Khash

Insulinomas are rare neuroendocrine tumours that classically present with a combination of symptomatic hypoglycaemia, low serum glucose values and resolution of symptoms post glucose ingestion.We describe a 65-year-old lady who repeatedly presented over several years with recurrent infections, predominantly of the urinary tract, nausea and diarrhoea, necessitating frequent hospital admissions. Despite extensive investigations, no clear cause for her symp...

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ea0035p553 | Endocrine tumours and neoplasia | ECE2014

Gastro-entero-pancreatic neuroendocrine tumors (GEPNETs) – 10 year experience of one center

Lewkowicz Ewelina , Trofimiuk-Muldner Malgorzata , Pach Dorota , Kieltyka Agnieszka , Staszczak Agnieszka , Sowa-Staszczak Anna , Gilis-Januszewska Aleksandra , Hubalewska-Dydejczyk Alicja

GEPNETs are rare tumors of very variable biology, particularly proliferative potential. Improved knowledge of the clinical course of disease may lead to proper identification of patients requiring more aggressive approach.Aim: i) characteristics of GEP-NET patients of the Endocrinology Department, University Hospital in Krakow, Poland; ii) identification of factors influencing their 5-year survival.Material and methods: Study inclu...

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ea0035p554 | Endocrine tumours and neoplasia | ECE2014

Epidemiology of gastro-entero-pancreatic neuroendocrine tumors in Krakow and Krakow district area

Trofimiuk-Muldner Malgorzata , Lewkowicz Ewelina , Pach Dorota , Kieltyka Agnieszka , Stefanska Agnieszka , Sowa-Staszczak Anna , Gilis-Januszewska Aleksandra , Hubalewska-Dydejczyk Alicja

Cancer registers are important tools in improving the knowledge of epidemiology of rare malignancies, such as gastro-entero-pancreatic neuroendocrine tumors.Aim: To assess the epidemiology of GEPNETs in Krakow and Krakow district area between January 2007 and December 2011.Material and methods: To assess the epidemiology of GEPNETs in Krakow area a register was created, based on independent sources of information. 88 patients (49 f...

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ea0035p555 | Endocrine tumours and neoplasia | ECE2014

Factors influencing survival of patients diagnosed with gastro-entero-pancreatic neuroendocrine tumors in Krakow and Krakow district area

Trofimiuk-Muldner Malgorzata , Lewkowicz Ewelina , Pach Dorota , Kieltyka Agnieszka , Stefanska Agnieszka , Sowa-Staszczak Anna , Gilis-Januszewska Aleksandra , Hubalewska-Dydejczyk Alicja

Abstract Identification of factors influencing survival of the gastro-entero-pancreatic neuroendocrine tumors patients may improve their management by better selection of subjects requiring more closed follow-up and more aggressive therapeutic approach.Aim: To assess factors influencing survival of GEPNET patients livingin Krakow and Krakow district area.Material and methods: The data from GEPNETs register run in t...

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ea0035p556 | Endocrine tumours and neoplasia | ECE2014

Catecholamin crisis as a first manifestation of multiple endocrine neoplasia type 2A

Zwolak Agnieszka , Rudzki Grzegorz , Swirska Joanna , Tarach Jerzy

Introduction: Multiple endocrine neoplasia type 2A (MEN2A) is a multi-glandular autosomal dominant genetic disorder which, most typically, includes medullary carcinoma of the thyroid, pheochromocytoma and primary hyperparathyroidism. The authors present a case study of a young man in whom cardiogenic shock was the first manifestation of pheochromocytoma and MEN2A.Case report: A 30-year-old man without a past history of hypertension or any other chronic m...

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ea0035p557 | Endocrine tumours and neoplasia | ECE2014

Adrenal incidentaloma: is it a disease of elderly? A clinical study of 2650 cases registered at a single endocrinological center

Kasperlik-Zaluska Anna , Otto Maciej , Cichocki Andrzej , Slapa Rafal , Rozkowszka Katarzyna , Slowinska-Srzednicka Janina , Roslonowska Elzbieta , Jeske Wojciech , Zdunowski Piotr , Zgliczynski Wojciech

It is generally believed that frequency of incidentally found adrenal tumours (adrenal incidentaloma(AI)) increases with age. Our study aimed at an analysis of age patterns in our group of patients with AI.Design: Material: 2650 patients, 1943 womens, 707 men. The diagnostic basis: clinical examination, imaging studies, hormonal determinations, pathomorphological and cytochemical investigations of the surgically removed 755 adrenal tumours. The material ...

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ea0035p558 | Endocrine tumours and neoplasia | ECE2014

Abstract unavailable....

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ea0035p559 | Endocrine tumours and neoplasia | ECE2014

Evaluation of demographic data of patients with adrenal incidentalomas

Bahceci Mitat , Gorgel Ahmet , Tutuncuoglu Aliye Pelin , Oruk Gonca , Yilmaz Husnu

Background and aim: Adrenal incidentalomas are discovered incidentally. Incidence has been increasing proportionally to the use of radiographic imaging. We aimed to evaluate patients with adrenal incidentalomas demographically.Subjects and methods: This study was performed between January 2010 and February 2013. Total 320 patients (55.4±11.7 years) with adrenal incidentaloma (86 (26.8%) male (55.2±11.6 years) and 234 (73.1%) female (56.2±1...

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ea0035p560 | Endocrine tumours and neoplasia | ECE2014

Expression of FSH hormone receptors in pituitary adenomas: a marker of tumour aggressiveness?

Pawlikowski Marek , Kunert-Radek Jolanta , Jaranowska Maria , Radek Maciej , Swietoslawski Jacek , Winczyk Katarzyna

Background: In our earlier study we found that pituitary adenomas, like other human tumours, express ectopically follicle stimulating hormone receptors FSH in intratumoral blood vessels endothelia and/or tumoral cells. The aim of the present paper is to provide the more detailed data on FSHR expression in different subtypes of pituitary adenomas and to evaluate its possible role as a prognostic and/or predictive biomarker in these tumours.Material and me...

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ea0035p561 | Endocrine tumours and neoplasia | ECE2014

Malignacy prevalance and related conditions in adrenal incidetaloma

Bahceci Mitat , Gorgel Ahmet , Tutuncuoglu Aliye Pelin , Oruk Gonca , Yilmaz Husnu

Background and aim: Incidence of adrenal incidentaloma is increasing proportionally to the use of radiographic imaging and there were two questions that whether malignant or functional. We aimed to evaluate patients with adrenal incidentalomas in terms of malignancy.Subjects and methods: This study was performed between 2010 and 2013. From 320 patients with adrenal incidentaloma, total 52 patients who underwent surgical intervetion were evaluated. Indica...

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ea0035p562 | Endocrine tumours and neoplasia | ECE2014

Consolidation treatment with somatoatatin analogues after radiopeptide therapy

Sygula Aleksandra , Handkiewicz-Junak Daria , Kotecka-Blicharz Agnieszka , Hasse-Lazar Kornelia , Jurecka-Lubieniecka Beata , Krajewska Jolanta , Jarzab Barbara

Background: Although neuroendocrine tumours (NET) constitute a very heterogeneous group, most of them express somatostatin receptors that enable treatment with somatostatin analogues(SA), which proved to be effective both as bio- or radiopeptide therapy. However, little is now about combining this two treatment modalities.The aim of our prospective study was to evaluate results of radiolabeled somatostatin analogues (PRRT) with or without long lasting cold SA as co...

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ea0035p563 | Endocrine tumours and neoplasia | ECE2014

Analysis of ultrasonographic parameters influencing thyroid nodules elasticity

Wolinski Kosma , Szczepanek-Parulska Ewelina , Stangierski Adam , Gurgul Edyta , Ruchala Marek

Introduction: Elastography is a method of tissue stiffness assessment. It was already demonstrated that thyroid cancers are less elastic than benign lesions. However, little is known about other factors, which might influence the stiffness of thyroid nodules and disrupt the prediction of malignancy using this technique. The aim of this study was to conduct the first systematic assessment of factors potentially affecting elasticity of thyroid lesions.Meth...

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ea0035p564 | Endocrine tumours and neoplasia | ECE2014

Differential TNFα and Toll-like-receptor 4-signaling in endocrine tumors after tumor- vascular- disrupting Agent ASA404 (Vadimezan) and TNFα treatment

Hantel Constanze , Lira Regia , Ozimek Alexandra , Frantsev Roman , Reincke Martin , Mussack Thomas , Beuschlein Felix

ASA404 (Vadimezan) belongs to a class of agents with disrupting properties against tumor vasculature. Herein, putative therapeutic applicability was investigated in preclinical models for neuroendocrine tumors of the gastroenteropancreatic system (BON) and adrenocortical carcinoma (NCIh295). Upon treatment of tumor bearing mice we detected a significant disruption of microvessels, decrease in cell proliferation, increase of apoptotic cells and extensive necrosis in BON tumors ...

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ea0035p565 | Endocrine tumours and neoplasia | ECE2014

Effect of thiazolidinediones: PPARγ agonists on hormones secretion by cells of human adrenocortical cancer in vitro

Fuss-Chmielewska Julita , Lawnicka Hanna , Swietoslawski Jacek , Beda-Maluga Karolina , Winczyk Katarzyna

Introduction: Adrenocortical carcinoma (ACC) is characterized by the high malignancy of the lesion, poor prognosis and high mortality rate. The surgical treatment and available chemotherapy have generally low efficacy so the search for new therapeutic options is still necessary. Some research indicated that thiazolidinediones (TZDs)synthetic ligands of peroxisome proliferator-activated receptor γ (PPARγ) have oncostatic action on neoplasm, including endocrine t...

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ea0035p566 | Endocrine tumours and neoplasia | ECE2014

Primary neuroendocrine carcinoma of renal: a rare case report

Budlewski Tadeusz , Szydlarska Dorota , Szalus Norbert , Kijek Jolanta , Chrapko Beata Ewa

We report a case of local recurrence and multiple lymph node and pulmonary metastases of renal carcinoid 1 year after nephrectomy in a 61-year-old woman. Primary renal carcinoid tumor arising from renal parenchyma or renal pelvis is a rare neoplasm. The patient was incidentally found to have a mass lesion in the left kidney and left nephrectomy was performed. Histological examination including immunohistochemical for chromogranin A and synaptophysin studies confirmed the diagn...

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ea0035p567 | Endocrine tumours and neoplasia | ECE2014

Neuroendocrine carcinomas of the thymus: two case reports

Sepp Krisztian , Csajbok Eva , Magony Sandor , Julesz Janos , Valkusz Zsuzsanna

The neuroendocrine tumor of thymus (TNET) is an extremely rare disease. It can occur sporadically or as a part of the multiple endocrine neoplasia (MEN1) syndrome. TNET may secret hormons (ectopic ACTH production). It is a potentially malignant tumor which often develops distant metastases. Its prognostic factors are the tumor size, histological grade, Ki67 index, paraneoplastic symptoms, surgical resection and Masaoka staging. The options for treatment are radical surgery, ch...

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ea0035p568 | Endocrine tumours and neoplasia | ECE2014

Expression of prolactin receptor in aldosterone-producing adrenal adenomas

Sustarsic Elahu , Riester Anna , Bielohuby Max , Beuschlein Felix , Reincke Martin , Bidlingmaier Martin

Scattered case reports have described patients who have been diagnosed with both primary hyperaldosteronism and prolactinoma. Prolactin receptor (PRLR) is known to be expressed in human adrenal cortex. Furthermore, PRLR mRNA and protein have both been detected in human adrenal tumors. It has also been shown that PRL treatment of adrenal cells is capable of stimulating aldosterone secretion. The contribution of PRL to the development of hyperaldosteronism is u...

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ea0035p569 | Endocrine tumours and neoplasia | ECE2014

Patient with dissemination of neuroendocrine neoplasm of unknown origin and carcinoid syndrome: diagnostic and therapeutic difficulties

Stefanka Agnieszka , Sowa-Staszczak Anna , Hubalewska-Dydejczyk Alicja , Mikolajczak Renata

Introduction: Serotonin producing neuroendocrine tumors are usually well differentiated, small lesions localised in the small intestine. Visualisation of the primary tumor might be difficult due to its small size.Case report: A 52 years old man presented with diarrhoea and flushes. Ultrasound examination and computed tomography of the abdomen revealed numerous lesions in the liver. Gastroscopy, colonoscopy and magnetic resonance imaging did not reveal th...

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ea0035p570 | Endocrine tumours and neoplasia | ECE2014

Uncertain clinical prognosis of pancreatic neuroendocrine tumour: case report

Stefanska Agnieszka , Sowa-Staszczak Anna , Hubalewska-Dydejczyk Alicja

Introduction: Despite development of diagnostic and therapeutic possibilities pancreatic neuroendocrine tumours remain still a clinical challenge.Case report: A 31-year-old woman after cholecystectomy performed in 2007. MRI performed in November 2008 due to abdominal pain revealed tumour of the pancreas 35×42×32 mm. In May 2009 patient underwent partial excision of the pancreas. On histopathological examination neuroendocrine tumour NET ...

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ea0035p571 | Endocrine tumours and neoplasia | ECE2014

Androgens regulate gene expression of glucose transporters and glycolytic enzymes in prostate cancer cells

Vaz Catia V , Alves Marco G , Marques Ricardo , Moreira Paula I , Oliveira Pedro F , Cavaco Jose E , Maia Claudio J , Socorro Silvia

Prostate cancer (PCa) is an endocrine tumor that presents distinct metabolic features associated with neoplastic development, namely in the transition from the androgen-dependent to the androgen-independent phenotype that characterizes advanced stages of prostate cancer. Recently, we have found that LNCaP (androgen-responsive) and PC3 (androgen-nonresponsive) PCa cells present distinct glycolytic metabolism profiles in consequence of altered gene expression and/or activity of ...

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ea0035p572 | Endocrine tumours and neoplasia | ECE2014

Peptide receptor radionuclide therapy as neoadjuvant treatment

Stefanska Agnieszka , Sowa-Staszczak Anna , Hubalewska-Dydejczyk Alicja , Mikolajczak Renata

Introduction: Peptide receptor radionuclide therapy is indicated in case of patients with disseminated neuroendocrine tumors and is usually considered as palliative treatment.Case reports: 55 years old man diagnosed with tumor of the pancreatic head. On laparotomy performed in June 2012 tumor was stated unresectable. Histopathological examination revealed the mixed adeno-neuroendocrine cancer (MANEC). Patient was qualified to chemotherapy with gemcitabin...

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ea0035p573 | Endocrine tumours and neoplasia | ECE2014

CD56 immunohistochemical expression: a useful tool for the diagnosis of in thyroid carcinomas of follicular origin

Cornianu Marioara , Golu Ioana , Amzar Daniela , Taban Sorina , Muresan Anca , Dema Alis

Introduction: CD56 (neural cell adhesion molecule/NKH1/LEU19 and LEU7/NHK-1) is an antigen related to follicular epithelium differentiation.Materials and methods: We evaluated the expression of CD56 protein in normal follicular thyroid tissue, 15 non-neoplastic thyroid lesions (nodular hyperplasiaNH, GravesBasedow disease (GB) and chronic lymphocytic/Hashimoto is thyroiditis (HT) and 38 thyroid neoplasias derived from follicular cells (25 PTC...

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ea0035p574 | Endocrine tumours and neoplasia | ECE2014

A clinical case of effective treatment of giant prolactinoma in patient with morbid obesity

Vorotnikova Svetlana , Dzeranova Larisa , Pigarova Ekaterina , Markina Natalya

Introduction: Numerous literature sources indicate the potential role of hyperprolactinemia in the development of obesity. Prolactin modulates the functional activity of several enzymes and transporters in adipose tissue and islets of Langerhans, potentially influencing fat and glucose metabolism. On the other hand, elevated prolactin level may induce eating disorders due to dysfunction of dopaminergic regulation of the CNS. We present a clinical case of a man with morbid obes...

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ea0035p575 | Endocrine tumours and neoplasia | ECE2014

Chemoembolization as a locoregional treatment for metastatic disease on a liver transplant from a bronchial carcinoid neuroendocrine tumor

Baena Juan Manuel Guardia , Luque Pedro Segura , Alonso Aurora Aragon , Justo Aisa Fornovi , Cascales Ana Belen Hernandez , Sajardo Raul Ballester , Gonzalez Luz Martinez , Espallardo Maria de los Angeles Campillo , Ortega Paloma Portillo , Monllor Marta Arraez , Gil Maria Dolores Hellin , Gomez Mercedes Ferrer , Sanchez Jose Ramon Cuenca , Conesa Juan Madrid , Martinez Antonio Hernandez , Masso Francisco Javier Tebar

Introduction: We present the results of chemoembolization used as a locoregional treatment for liver metastases (on a transplanted liver) from a bronchial carcinoid neuroendocrine tumor with stage IV disease progression.Case report: A 60-year-old man diagnosed of bronchial carcinoid NET in 2002, underwent surgery by lung lobectomy and excision of lymph node metastases. Treated also with somatostatin analogues (SA) after subsequent discovery of liver meta...

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ea0035p576 | Endocrine tumours and neoplasia | ECE2014

Correlation between atypical pituitary adenomas and Ki-67 Li: clinical and prognostic aspects

Chiloiro Sabrina , Bianchi Antonio , Giampietro Antonella , Iacovazzo Donato , Trapasso Barbara , Piacentini Serena , Tartaglione Linda , Lugli Francesca , De Marinis Laura

Introduction: In 2004, the WHO defined atypical pituitary adenomas (APAs) those with Ki-67 >3%, excessive p53 expression and increased mitotic activity. The usefulness of this classification is still controversial.Aim: To compare the clinical and prognostic features in a series of typical and atypical pituitary adenomas.Materials and methods: We retrospectively reviewed 343 consecutive PAs. APAs represented 18.7% of the cases. ...

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ea0035p577 | Endocrine tumours and neoplasia | ECE2014

Patient-reported outcomes associated with lanreotide Autogel (LAN-ATG) for symptom control of carcinoid syndrome in gastroenteropancreatic neuroendocrine tumour patients: results of SYMNET, a large International Multicentre Observational Study

Ruszniewski Philippe , Caplin Martyn , Valle Juan , Lombard-Bohas Catherine , Poston Graeme , Perros Petros , Holubec Lubos , Fave Gianfranco Delle , Smith Denis , Niccoli Patricia , Maisonobe Pascal , Atlan Philippe

Introduction: Somatostatin analogues are widely used to reduce the incidence and severity of carcinoid syndrome symptoms. However, their impact on patients satisfaction with symptom control needs further investigation. SYMNET was a large international multicentre observation study that assessed PROs during LAN-ATG treatment of carcinoid syndrome in gastroenteropancreatic neuroendocrine tumour (GEPNET) patients.Methods: At routine clinic visit...

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ea0035p578 | Endocrine tumours and neoplasia | ECE2014

Antiproliferative effects of lanreotide Autogel in patients with enteropancreatic neuroendocrine tumours: results of CLARINET, a large international phase 3 study

Caplin Martyn , Ruszniewski Philippe , Pavel Marianne , Cwikla Jaroslaw , Phan Alexandria , Raderer Markus , Sedlackova Eva , Cadiot Guillaume , Wall Lucy , Rindi Guido , Langley Alison , Blumberg Joelle

Introduction: Data demonstrating antiproliferative effects of somatostatin analogs (SSAs) in enteropancreatic NETs are limited; only one prospective trial so far has shown this for patients with midgut tumors and low hepatic tumor load (HTL). CLARINET is the first large phase 3, randomized, placebo-controlled trial evaluating such effects for the SSA lanreotide in patients with non-functioning enteropancreatic NETs.Methods: Patients who had well/moderate...

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ea0035p579 | Endocrine tumours and neoplasia | ECE2014

Efficacy and safety of lanreotide Autogel treatment for carcinoid syndrome in patients with gastroenteropancreatic neuroendocrine tumors: results of ELECT, a large multinational phase 3 study

Gomez-Panzani Edda , Vinik Aaron , Wolin Edward , Audry Helen

Introduction: Somatostatin analogues (SSAs) are the mainstay treatment for carcinoid syndrome. ELECT is a large multinational phase 3 study evaluating rescue therapy use as a measure for control of carcinoid syndrome symptoms with LAN-ATG.Methods: Eligible patients had histologically-confirmed GEP-NETs and history of carcinoid syndrome, and were SSA-naïve or responsive to conventional doses of octreotide LAR (≤30 mg/4 weeks) or short-acting (&...

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ea0035p580 | Endocrine tumours and neoplasia | ECE2014

Plasma free metanephrine, normetanephrine and 3-methoxytyramine for the differential diagnosis of pheochromocytoma and paraganglioma

Gupta Poonam , Khurana Madan Lal , Sharma S C , Bal C S , Ammini A C

Background: Pheochromocytoma (PHEO) and paraganglioma (PGL) of abdominal origin secrete catecholamines which are metabolized to metanephrines. Head-and-neck paraganglioma (HNPGL) are considered as non secretary tumors.Objectives: To find the utility of plasma free metanephrine (MN), normetanephrine (NMN) and 3-methxytyramine (3-MT) for the differential diagnosis PHEO/PGL after excluding MEN2 and VHL patients.Methods: A total of 79 ...

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ea0035p581 | Endocrine tumours and neoplasia | ECE2014

Is early repeat surgery a feasible concept for potential incomplete resection in acromegaly?

Rotermund Roman , Lautenbach Anne , Burkhardt Till , zur Wisch Clarissa Schulze , Aberle Jens , Flitsch Jorg

Transsphenoidal surgery is the treatment of choice for acromegaly. Cure is defined by normalization of age-related IGF1 and sufficient suppression of GH in the oral glucose tolerance test (OGTT). We investigated, if early postoperative hormone testing gives reliable information whether complete resection of a tumor was achieved and compared these findings with further follow-up data.So far, 22 patients underwent OGTT within a week after surgery, starting...

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ea0035p582 | Endocrine tumours and neoplasia | ECE2014

Eleven base pair (AACACTCTAGC) deletion of SDHB Ex-4 from c.325 to c.335 in the patient with malignant Vaginal Paraganglioma – A case report

Gupta Poonam , Khurana Madan Lal , Ammini A C , Bal C S

Background: Pheochromocytoma (PHEO) and paraganglioma (PGL) are the tumors of adrenal medulla and extra adrenal ganglia respectively. Most of these PHEO/PGL are benign and may become malignant, if remain undiagnosed/untreated for a longer time. Vaginal PGL are extremely rare. There is not much published literature on vaginal PGL.Objective: To carry out biochemical and genetic analysis of the patient with MIBG negative malignant vaginal PGL.<p class="...

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ea0035p583 | Endocrine tumours and neoplasia | ECE2014

^99mTc-GLP-1 scintigraphy, an efficient method for the detection of insulinoma: results of 3 years’ experience

Hubalewska-Dydejczyk Alicja , Sowa-Staszczak Anna , Pach Dorota , Tomaszuk Monika , Stefanska Agnieszka , Buziak-Bereza Monika , Jabrocka-Hybel Agata , Gilis-Januszewska Aleksandra , Malecki Maciej , Bednarczuk Tomasz , Kaminski Grzegorz , Kowalska Aldona , Trofimiuk-Muldner Malgorzata , Mikolajczak Renata , Janota Barbara

Introduction: The aim of this study was to assess the diagnostic efficiency of [Lys40(Ahx-HYNIC-99mTc/EDDA)NH2]-exendin-4 scintigraphy in the detection of hardly detectable or not diagnosed by other available method insulinomas.Materials and methods: 37 patients (24 women and 13 men, mean age 46.5±17.8 years, min. 16.0 years, max. 77.0 years) were enrolled in this study. There were 32 patients with clinical and bioch...

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ea0035p584 | Endocrine tumours and neoplasia | ECE2014

The first experience of video-assisted resection of the thyroid gland in the Republic of Kazakhstan

Arzykulov Zhetkergen , Shaikhiyev Yerbol , Juraev Shakir , Shokebayev Adil , Aliev Arman , Imammyrzayev Nurmakhan , Tanabaev Janat

Background: Videoassisted resection of the thyroid gland with unilateral nodular lesions of the thyroid gland, as compared to the conventional method is a safe and effective method.Materials and methods: Patient M, a woman 30 years old, BMI 30.37. Admitted with complaints of discomfort and a feeling of constriction in the neck, mild shortness of breath on exertion. The cervical lymph nodes were not enlarged. According to the USI are found nodes in the ri...

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ea0035p585 | Endocrine tumours and neoplasia | ECE2014

Combined therapy PRRT with long acting somatostatin analogue: results of 7 years’ experience

Sowa-Staszczak Anna , Stefanska Agnieszka , Buziak-Bereza Monika , Trofimiuk-Muldner Malgorzata , Mikolajczak Renata , Tomaszuk Monika , Hubalewska-Dydejczyk Alicja

Introduction: The aim of this study was to assess the survival rate of patients with disseminated or inoperable neuroendocrine tumors (NETs) after PRRT with the use of 90Y-DOTATATE combined with long acting somatostatin analogue.Materials and methods: 72 patients were treated with PRRT in our Department. The 90Y-DOTATATE therapeutic activity was calculated per total body surface area up to a total of 7.4 GBq/m2 administra...

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ea0035p586 | Endocrine tumours and neoplasia | ECE2014

The anti-proliferative effect of anti-EGFR tyrosine kinase inhibitor in combination with mitotane on H295R adrenocortical cancer cells

Dworakowska Dorota , Dudka Dorota , Weistman Gregory , King Peter , Diaz-Cano Salvador , Korbonits Marta , Grossman Ashley B , Aylwin Simon , Schulte Klaus-Martin , Sworczak Krzysztof , Ng Tony

Introduction: Adrenocortical carcinoma (ACC) is a rare disease with a poor prognosis and limited therapeutic options. Mitotane is considered as a first-line therapy but only 30% of the patients showing an objective tumour response.Erlotinib and gefitinib (tyrosine kinase inhibitors TKI) inhibit the epidermal growth factor receptor (EGFR), which is highly expressed and occasionally mutated in various cancers. EGFR expression was found to be a good ...

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ea0035p587 | Endocrine tumours and neoplasia | ECE2014

Gonadal tumor incidence in 45,X/46,XY and 46,XY female patients: experience from one clinical center

Gawlik Aneta , Antosz Aleksandra , Zachurzok Agnieszka , Matusik Pawel , Kaminska Halla , Kudela Grzegorz , Koszutski Tomasz , Malecka-Tendera Ewa

Type II germ cell tumors are predictable complications in patients with disorder of sex development (DSD) and with Y chromosome present. The risk of tumor development varies significantly between subsets of DSD and in some cases early gonadectomy is perceived as overtreatment.The aim of the study was to analyze the gonadal tumor incidence in 45,X/46,XY and 46,XY patients who were reared as female and managed at single institution between 1997 and 2013.</...

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ea0035p588 | Endocrine tumours and neoplasia | ECE2014

Ovarian tumors in endocrinology: about a series of 17 cases

Laloui Amina , Haddam Ali El Mahdi , Fedala Soumeya , Meskine Djamila , Chentli Farida

Introduction: The ovarian tumors are benign or malignant, primary or secondary proliferative processes, cystic aspect, solid or vegetating, whose growth is not directly related to a Hormonal dysfunction. They can grow at the coating tissue, be embryonic or endocrine origin.Aim: Assess the frequency of ovarian tumors and clarify their phenotypic and evolutionary characteristics.Population and methodology: This is a retrospective stu...

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ea0035p589 | Endocrine tumours and neoplasia | ECE2014

Asymptomatic advanced neuroendocrine ovarian tumor: case report

Krcma Michal

Introduction: Incidence of neuroendocrine neoplasms is still growing very rapidly. Many of these tumours are long term asymptomatic, definitive diagnose is confirmed in very advanced stage and make treatment difficult. Our case report illustrates diagnostic contribution of endoscopic adrenal biopsy.Our patient was a woman, 68 years old in time of diagnosis, with good quality of life. One year before she was undergone hysterectomy with bilateral adnexecto...

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ea0035p590 | Endocrine tumours and neoplasia | ECE2014

Analysis of factors affecting the repeatability and reproducibility of elastographic measurements of thyroid nodules

Brzozowski Kamil , Wojtaszek-Nowicka Martyna , Lukowska Joanna , Klencki Mariusz , Slowinska-Klencka Dorota

Background: Elastography is an ultrasound technique that allows to predict risk of malignancy of examined lesion by assessing their stiffness. Its effectiveness in thyroid nodules is equivocal which may result from insufficient standardization.Aim: Analysis of factors affecting the repeatability and reproducibility of elastographic measurements of thyroid nodules.Methods: 124 nodules in 118 patients were analyzed. Elastographic mea...

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ea0035p591 | Endocrine tumours and neoplasia | ECE2014

Should unifocal papillary thyroid microcarcinoma be treated as much radically as multifocal one?

Guminska Anna , Bakula-Zalewska Elwira , Benke Malgorzata , Bruszewska Elzbieta , Czetwertynska Malgorzata , Dlugosinska Joanna , Garszel Anna , Godlewska Paulina , Musial Emilia , Niewiadomska Joanna , Dedecjus Marek

Introduction: Multifocal papillary thyroid microcarcinama (PTmC) has been considered as more aggressive than the unifocal one.Aim of the study: This paper aims to compare this two groups considering histopatological sign of aggressivity, presence of inflammation and radioiodine uptake.Materials and methods: The analysis concerned 81 patient with microcarcinoma (PTmC) selected from group of 961 (8%) diagnosed and treated in conventi...

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ea0035p592 | Endocrine tumours and neoplasia | ECE2014

Pancreatic neuroendocrine tumour with a silent long evolution: case report

Manolachie Adina , Crumpei Felicia , Volovat Constantin , Bodescu Ioana , Idriceanu Jeanina , Vasiliu Ioana , Fadur Alina , Preda Cristina , Vulpoi Carmen

Pancreatic neuroendocrine tumors (pNET) represent 1.3% of pancreatic tumours, ~65% patients presenting with metastatic/unresectable disease. Clinically, pNET may be asymptomatic, accompanied by carcinoid syndrome or abdominal pain.Patient N.A. aged 73, with a history of hemorrhagic pancreatitis, was diagnosed in 2003 with a hyperechoic heterogeneous solid pancreatic tumour of 28/28 mm. No therapy/monitoring were proposed. After 7 years of asymptomatic ev...

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ea0035p593 | Endocrine tumours and neoplasia | ECE2014

IGF1 gene polymorphism and thyroid cancer

Soyluk Ozlem , Aral Ferihan , Boztepe Harika , Kapran Yersu , Erbil Yesim , Ustek Duran , Abaci Neslihan , Colak Nese

Aim: Several studies suggested that there is a relationship between serum levels of IGF1 or their polymorhisms and some cancer types. The genetic polymorphism in the region of IGF promoter region which is composed of cytosineadenine repeats, affects the promoter activity. It is suggested that serum IGF1 levels are inversely associated with the length of CA repeats. There are studies reporting that the carriers of the CA 19 allele are more likely to develop some cancer ty...

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ea0035p594 | Endocrine tumours and neoplasia | ECE2014

Comparison of elastography and conventional ultrasonography in the diagnostics of thyroid nodules, elastographic features of follicular lesions of undetermined significance

Wojtaszek-Nowicka Martyna , Brzozowski Kamil , Lukowska Joanna , Sporny Stanislaw , Popowicz Bozena , Klencki Mariusz , Slowinska-Klencka Dorota

Background: Elastography is a procedure that widen diagnostic ultrasonography (US) but its significance in thyroid diagnostics has not been settled.Aim: Comparison of usefulness of elastography and conventional malignancy risk features (MRF) in the diagnostics of thyroid nodules, analysis of elastographic characteristics of follicular lesions of undetermined significance (FLUS).Methods: Analysis included 38 benign lesions (BL), 15 ...

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ea0035p595 | Endocrine tumours and neoplasia | ECE2014

Preoperative octreotide therapy in acromegaly: associations between effects on glucose homeostasis and biochemical cure

Helseth Ragnhild , Carlsen Sven , Bollerslev Jens , Svartberg Johan , Oksnes Marianne , Skeie Svein , Fougner Stine L

Objective: In acromegaly, high GH/IGF1 levels are associated with abnormal glucose metabolism. Treatment with somatostatin analogues (SSAs) reduces the GH and IFG-1 levels. However, SSAs may worsen glucose homeostasis despite this, due to concomitant inhibition of insulin secretion. We studied the possible association between biochemical cure and glucose homeostasis in de novo patients with acromegaly.Design: Post hoc analysis from a ra...

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ea0035p596 | Endocrine tumours and neoplasia | ECE2014

Pulmonary neuroendocrine tumor presenting with thyroid gland metastasis: a case report

Radu Cristina Corina Pop

Introduction: Neuroendocrine tumors (NET) represent ~20% of all primary neoplasms of the lung. Histologic confirmation is important for treatment and prognosis determination. NET are classified according to four subtypes in the lung: typical carcinoid tumor (TC), atypical carcinoid tumor (AC), small cell carcinoma (SCC), and large cell neuroendocrine carcinoma (LCNEC). TC is low-grade, AC is intermediate-grade, and SCC and LCNEC are high-grade malignancies.<p class="abstex...

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ea0035p597 | Endocrine tumours and neoplasia | ECE2014

Everolimus in monotherapy as a therapeutic option in paragangliomas/pheochromocytomas

Cuadro Alberto Torres , Rodriguez Jose Perez , Tamarit Ana Albero , Hernandez Tomas Martin , Rivera Natividad Gonzalez , Zoilo Juan Jose Reina , Carrasco Fernando Henao , Merino Luis De La Cruz

Introduction: Everolimus is a drug selective inhibitor of mTOR. In 2012 a Phase 2 study* of everolimus monotherapy demonstrated modest efficacy in patients with pheochromocytomas/paragangliomas. Our objective was to evaluate the efficacy and safety of everolimus in a patient with paraganglioma. (*Phase 2 study of everolimus monotherapy in patient with nonfunctioning neuroendocrine tumor or pheochromocytomas/paraglangliomas. Do-Young Oh et al. Cancer 2012 <str...

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ea0035p598 | Endocrine tumours and neoplasia | ECE2014

Expression of somatostatin and dopamine receptors in neuroendocrine tumors: correlation of immunohistochemical findings with somatostatin receptor scintigraphy visual scores

Diakatou Evanthia , Tsolakis Apostolos , Alexandraki Krystallenia , Chatzellis Eleftherios , Leonti Anastasia , Kontogeorgos Georgios , Kaltsas Gregory

Background: The expression and/or co-expression of somatostatin (sstr15) and dopamine (DR) receptors in neuroendocrine tumors (NETS) is of clinical interest as their expression implies that NETS could be treated with combined targeted therapy. In addition, the expression of sstrs permits tumour visualization with radiolabelled sst analogs (111In-DTPA-OctreoScan).Methods: We analyzed preoperative Octreoscans findings (also graded for the ...

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ea0035p599 | Endocrine tumours and neoplasia | ECE2014

Analysis of allelic imbalance frequency in 10q region covering PAPSS2 and PTEN loci in follicular cell-derived thyroid tumours

Migdalska-Sek Monika , Czarnecka Karolina H , Kusinski Michal , Nawrot Ewa , Pastuszak-Lewandoska Dorota , Domanska Daria , Kiszalkiewicz Justyna , Brzezianska Ewa

Genetic instability, i.e. loss of heterozygosity (LOH) and microsatellite instability (MSI) represent molecular disorders acquired by the cell during neoplastic transformation. Genetic instability is a frequent molecular event in thyroid pathogenesis, found at the early and the late stages of thyroid tumorigenesis. In thyroid neoplasms genetic instability was found in many chromosomal regions and is observed especially in cell-derived thyroid tumours. Alterations in PTEN loci ...

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ea0035p600 | Endocrine tumours and neoplasia | ECE2014

Cushing’s syndrome caused by ectopic corticotrophin secretion

Przybylik-Mazurek Elwira , Kuzniarz-Rymarz Sylwia , Pach Dorota , Sowa-Staszczak Anna , Gilis-Januszewska Aleksandra , Hubalewska-Dydejczyk Alicja

Cushings syndrome caused by ectopic ACTH secretion (EAS) constitutes ~10% of Cushings syndrome (CS).The aim of this study was to present experience of our Clinic with EAS.).Patients: Twelve patients, aged 1470 years: four females and eight males.Outcomes and measurements: Clinical features, medical examination, morning electrolytes, glucose level, serum cortisol, ACTH levels, midnight plasma...

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ea0035p601 | Endocrine tumours and neoplasia | ECE2014

Expression of proliferating markers: PCNA and Cdk1 in hyperplastic lesions of the parathyroid glands

Segiet Oliwia , Bula Grzegorz , Deska Mariusz , Gawrychowski Jacek , Wojnicz Romuald

Background: Proliferating cell nuclear antigen (PCNA) is a cell cycle marker protein. It interacts with more than 100 proteins involved in DNA replication, DNA repair, cell cycle control, chromatin remodeling/epigenetic inheritance, chromatid cohesion and transcription. Cyclin-dependent kinase 1 (Cdk1) is a serine/threonine protein kinase which regulates diverse cell cycle transitions (G1/S, S and G2/M phases) and associates with different cell-cycle stage-specific cyclins. Bo...

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ea0035p602 | Endocrine tumours and neoplasia | ECE2014

Immunohistochemical assessment of parafibromin in primary hyperparathyroidism

Segiet Oliwia , Deska Mariusz , Bula Grzegorz , Gawrychowski Jacek , Wojnicz Romuald

Background: Parafibromin is an ubiquitously expressed protein and a member of the polymerase-associated factor 1 complex associated with RNA polymerase II, which regulates transcription elongation, histone modification and cell proliferation. It is encoded by the CDC73 gene also known as the HRPT2 gene. Endogenous parafibromin inhibits expression of MYC gene that encodes the c-Myc proto-oncogene. Parafibromin has three nuclear localization signals, a...

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ea0035p603 | Endocrine tumours and neoplasia | ECE2014

Apoptotic cell index in non-neoplastic lesions of the parathyroid glands

Segiet Oliwia , Michalski Marek , Piecuch Adam , Gawrychowski Jacek , zaba Malgorzata , Wojnicz Romuald

Background: Primary hyperparathyroidism is one of the most common endocrine disorders caused by adenoma (80%), hyperplasia (15%) and carcinoma (5%). It is often difficult to differentiate between hyperplasia from an adenoma of a parathyroid gland. Accordingly, the aim of this study was to assess apoptotic index as a potentially useful in diagnosis.Methods: Apoptotic cells was investigated in the parathyroid specimens of 21patients (4M, 17F, average age o...

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ea0035p604 | Endocrine tumours and neoplasia | ECE2014

Neuroendocrine cancer of the ampulla of Vater: clinical course in seven patients: material of Department of Endocrinology in Szczecin, Poland

Andrysiak-Mamos Elzbieta , Sowinska-Przepiera Elzbieta , Lubikowski Jerzy , Syrenicz Justyna , Zochowska Ewa , Kiedrowicz Bartosz , Starzynska Teresa , Syrenicz Anhelli

Introduction: Neuroendocrine cancer of the ampulla of Vater area belongs to the most rare GEP-neuroendocrine tumors (NET). In the literature, there are few reports of extremely malignant course of this cancer. Among 242 patients with NET from the Department of Endocrinology in 20092013, 58 pancreatic NET were discovered, among which seven patients had neuroendocrine cancer of the ampulla of Vater. The aim of this study was to determine the clinical characteristics, stagi...

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ea0035p605 | Endocrine tumours and neoplasia | ECE2014

‘Noninsulinoma pancreatogenous hypoglycemia syndrome’; a case report of adult nesidioblastosis from Turkey

Cander Soner , Gul Ozen Oz , Erturk Erdinc

The most common reason for the rare condition of hyperinsulinemia-related hypoglycaemia is insulinoma, a tumor of pancreatic islet cells. However, nesidioblastosis characterized by diffuse or focal hyperplasia of the pancreatic islet cells is the most common cause of hyperinsulinemic hypoglycemia in newborns. Nesidioblastosis seen in newborns is now called persistent hyperinsulinemic hypoglycemia of infancy (PHHI) while the condition in adults is called nonin...

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ea0035p606 | Endocrine tumours and neoplasia | ECE2014

Breast metastasis from medullary thyroid carcinoma in a man

Mandanas Stylianos , Margaritidou Efterpi , Georgopoulos Konstantinos , Boudina Maria , Chrisoulidou Alexandra , Pazaitou-Panayiotou Kalliopi

Introduction: Medullary thyroid carcinoma (MTC) originated from parafollicular C cells of the thyroid gland is a rare histological type of malignancy. Common sites of metastases are liver, lungs and bones, while metastases in other sites are extremely rare. Breast metastases from MTC are reported in 20 cases, and only in women.Case report: A 67-year-old man was presented after thyroidectomy for further evaluation and treatment. Histology was positive for...

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ea0035p607 | Endocrine tumours and neoplasia | ECE2014

A rapid thymic carcinoma in a patient with multiple endocrine neoplasia type 1

Lila Brakni , Zahra Kemali

Introduction: Thymic neuroendocrine (NE) tumors associated with multiple endocrine neoplasia type 1 (MEN1) are rare, variably documented in 18% cases. They are malignant and aggressive tumors and form a major cause of mortality in MEN1.We report a case of thymic NE carcinoma developing rapidly after parathyroidectomy in a MEN1 patient.Case: A 45 years old man was allowed for headaches, the biology showed a hypercalcemia, a hy...

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ea0035p608 | Endocrine tumours and neoplasia | ECE2014

Metastatic bone disease in patients with neuroendocrine tumors

Alexandraki Krystallenia , Chrysochoou Maria , Kaltsatou Maria , Chatzellis Eleftherios , Tsoli Marina , Boutzios Georgios , Thomas Dimitrios , Kaltsas Gregory

Objective: The prevalence of metastatic bone disease in patients with neuroendocrine tumours (NETs) and their response to first line treatment with biphosphonates.Methods: We studied 271 patients (141 females) with NETs: 54 gastric, nine duodenal, 102 pancreatic, 29 small intestine, 29 appendix, 14 colon, 15 lung, one thymic, 20 unknown primary and ten elsewhere. Since September 2012 all patients with NETs and bone metastases were recruited to receive 4 ...

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ea0035p609 | Endocrine tumours and neoplasia | ECE2014

Adrenocortical carcinomas: retrospective analysis of the last 22 years

Guelho Daniela , Paiva Isabel , Vieira Alexandra , Saraiva Joana , Moreno Carolina , Vicente Nuno , Cardoso Luis , Carrilho Francisco

Introduction: Adrenocortical carcinoma (ACC) is a rare disease, with a severely adverse prognosis. Clinical reports, even when including a limited number of cases, can contribute to its knowledge. This study aims to characterize patients followed at our department between 1991 and 2013.Methods: Retrospective analysis of the clinical records of patients with pathological confirmation of ACC. Statistical analysis: SPSS21.Results: 22 ...

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ea0035p610 | Endocrine tumours and neoplasia | ECE2014

The value of parathyroid hormone determination in ultrasound-guided fine-needle aspirates (FNA–PTH) for preoperative localization of parathyroid lesions.

Kochman Magdalena , Misiorowski Waldemar , Papierska Lucyna , Stachlewska-Nasfeter Elzbieta , Chudzinski Witold , Cwikla Jaroslaw

Introduction: Ultrasound imagining of parathyroid lesions is often challenging, as they may be difficult to distinguish from thyroid lesions or enlarged lymph nodes.Aim: The aim of the study was to assess the value of parathyroid hormone determination in ultrasound-guided fine-needle aspirates-(FNA) in preoperative localization of parathyroid lesions.Materials and methods: We measured FNAPTH in 30 consecutive patients with pr...

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ea0035p611 | Endocrine tumours and neoplasia | ECE2014

TSH suppressive therapy accelerates progression of sacropenia in post-menopausal women

Diedhiou Demba , Klein Marc , Weryha Georges , Feigerlova Eva

Background: TSH-suppressive therapy in patients with differentiated thyroid carcinoma (DTC) leads to iatrogenic thyrotoxicosis and may be associated with alterations in body composition and bone mineral density (BMD). Its effects on a sarcopenia in elderly have not been in detail investigated.Objective: The objective was to compare changes in total and areal lean body mass (LBM), body fat mass (BFM) and BMD in postmenopausal female patients with DTC duri...

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ea0035p612 | Endocrine tumours and neoplasia | ECE2014

Metabolic and cardiovascular complications in patients with adrenal incidentalomas

Gheorghiu Monica Livia , Voicu Alina , Caragheorgheopol Andra , Coculescu Mihai , Poiana Catalina

Introduction: We evaluated the prevalence of metabolic and cardiovascular complications in a Romanian population with adrenal incidentalomas in comparison with an age-matched control group, evaluated in our clinic.Patients and methods: After excluding patients with overt functioning adrenal tumors, subclinical pheochromocytomas, malignant tumors, myelolipomas, data were retrieved from the files of 190 patients with adrenal incidentalomas ≥1 cm and ...

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ea0035p613 | Endocrine tumours and neoplasia | ECE2014

Circulating tumor cells in neuroendocrine tumor patients

Ehlers Margret , Allelein Stephanie , Dringenberg Till , Haase Matthias , Schinner Sven , Willenberg Holger S , Schott Matthias

Introduction: Neuroendocrine tumors (NET) are heterogenous tumors with variable survival and the frequently occurring ability to metastasize. A basis for metastasis of tumors is invasive growth. One factor participating in this process is the existence of the so called circulating tumor cells (CTC) in the peripheral blood. Up to now there is only rare data available regarding the number of CTCs in NET patients.Methods: EpCAM protein expressio...

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16th European Congress of Endocrinology

BiosciAbstracts