Endocrine Abstracts

Background: Alpelisib is a novel phosphotidylinositol 3-kinase (PI3K) inhibitor which, in combination with fulvestrant, has been shown to increase progression-free survival in patients with HR+/HER2-/PI3KCA mutated advanced breast cancer[1]. Hyperglycaemia, including alpelisib-induced diabetic ketoacidosis is a known adverse effect, along with rash, diarrhoea and stomatitis. No other associated endocrinopathy has been reported to date. Case presentation: We present th...

The causative link between circulating glucocorticoid excess and osteoporosis is established. Although circulating cortisol levels do not change significantly with age, local tissue metabolism may be implicated in age-related bone loss. The enzyme11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) increases local cortisol production, is expressed in human osteoblasts and its activity increases with age leading to a decrease in bone formation. We hypothesised that sele...

Phaeochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumours, the majority of which secrete excess catecholamines resulting in significant hypertension and tachycardia. Pre-operative blood pressure control with alpha-adrenoceptor blockade is therefore implemented. The aim of the study was to assess the pre-, intra- and post-operative outcomes of patients undergoing outpatient alpha-blockade in our centre. A retrospective chart analysis was conducted on patients w...