Searchable abstracts of presentations at key conferences in endocrinology

ea0031p181 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

The role of hepatic 11β-hydroxysteroid dehydrogenase type 1 in cholesterol homeostasis

Manwani Kajal , Man Tak Y , Kenyon Christopher J , Andrew Ruth , Chapman Karen E , Seckl Jonathan R

11β-Hydroxysteroid dehydrogenase type one (11β-HSD1) converts inert glucocorticoids to active forms, amplifying intracellular glucocorticoid action. 11β-HSD1 also catalyses the reduction of seven-ketocholesterol (7KC) to 7β-hydroxycholesterol (7βHC). 7KC may inhibit cholesterol biosynthesis (Brown et al. 2002). Alteration of cholesterol homeostasis is a major atherosclerotic risk factor. 11β-HSD1 deficiency/inhibition is atheroprotective ...

ea0031p189 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

The role of glucocorticoid metabolism in bile acid homeostasis

Opiyo Monica Naomi , Kenyon Christopher , Manwani Kajal , Man Tak , Seckl Jonathan , Andrew Ruth , Chapman Karen

Background and aims: Bile acids regulate cholesterol metabolism and the digestive system. They are conserved through enterohepatic circulation, a glucocorticoid-modulated process. We investigated whether the regeneration of active glucocorticoid by 11β-hydroxysteroid dehydrogenase type one (11β-HSD1) affects bile acid release and enterohepatic transport after re-feeding.Methods: Bile acid turnover was assessed in global (Hsd11b11<...