Obesity, diabetes, metabolism and cardiovascular

Association of calcium-sensing receptor polymorphisms with vascular calcification and glucose homeostasis in renal transplant recipients

Babinsky Valerie N Hannan Fadil M Youhanna Sonia Devuyst Olivier Thakker Rajesh V

¹Academic Endocrine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK; ²Institute of Physiology, University of Zurich, Zurich, Switzerland.

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Testosterone stimulates cholesterol efflux and metabolism in human macrophages via liver X receptor

Kilby Elizabeth Jones Hugh

¹University of Sheffield, Sheffield, UK; ²Barnsley Hospital NHS Foundation Trust, Barnsley, UK.

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FGF21 action on human adipose tissue compromised by reduced [beta]Klotho and FGFR1 expression in type 2 diabetes mellitus

Piya Milan K Harte Alison L Chittari Madhu V Tripathi Gyanendra Kumar Sudhesh McTernan Philip G

¹Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry, UK; ²Warwickshire Institute for the Study of Diabetes Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.

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A component of transcriptional PRC2 complex, enhancer of zest homology, modulates endothelial cell responses to hypoxia and post-ischemic angiogenesis in a mouse model of limb ischemia

Mitic Tijana Anannya Orchi Emanueli Costanza

Bristol Heart Institute, University of Bristol, Bristol, UK.

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The role of hepatic 11[beta]-hydroxysteroid dehydrogenase type 1 in cholesterol homeostasis

Manwani Kajal Man Tak Y Kenyon Christopher J Andrew Ruth Chapman Karen E Seckl Jonathan R

University of Edinburgh, Edinburgh, UK.

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Vitamin B12 and folate imbalance induces cholesterol synthesis and endoplasmic reticulum stress in human adipocytes

Adaikalakoteswari Antonysunil Moore Jonathan Ciara Mccarthy Voyais Philip Mcternan Philip Saravanan Ponnusamy Tripathi Gyanendra

¹Division of Metabolic and Vascular Health, University of Warwick, Warwick, UK; ²Systems Biology Centre, University of Warwick, Warwick, UK.

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The effects of Syzygium aromaticum-derived oleanolic acid on reactive oxygen species in the heart, liver and kidney of STZ-induced diabetic rats

Mkhwanazi Blessing Sibiya Ntethelelo Serumala Metse Myburg Rene Musabayane Cephas T

University of KwaZulu-Natal, KwaZulu-Natal, South Africa.

ePoster

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Effects of vitamin D supplementation on blood pressure, glucocorticoids and cardiovascular risk markers in healthy subjects

Al-dujaili Emad Giudice Veronica Fyfe Lorna Kita Joanna

Queen Margaret University, Edinburgh, Scotland, UK.

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Knockdown of brain 11[beta]-HSD1 does not lower body weight or improve insulin sensitivity

Harno Erika Cottrell Elizabeth C DeSchoolmeester Joanne Turnbull Andrew V Leighton Brendan White Anne

¹University of Manchester, Manchester, UK; ²AstraZeneca, Alderley Park, UK.

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C-type natriuretic peptide down regulates interferon [gamma] mediated pro-inflammatory gene expression in human endothelium

Day Amy Fowkes Robert Lawson Charlotte

Royal Veterinary College, London, UK.

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Acute effects of co-infusion of peptide YY (3[ndash]36) and glucagon-like peptide-1 on insulin secretion and insulin sensitivity

Tan Tricia Salem Victoria Troke Rachel De Silva Akila Alsafi Ali Misra Shivani Baynes Kevin Ghatei Mohammed Minnion James Field Ben Godsland Ian Bloom Stephen R

¹Division of Diabetes, Endocrinology and Metabolism, Imperial College London, Hammersmith Hospital, London, UK; ²Division of Endocrinology and Metabolic Medicine, Department of Medicine, Imperial College London, St Mary’s Hospital, London, UK.

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Human abdominal subcutaneous adipocytes as an active source of LpPLA2, influenced by fat depot and metabolic state, with LpPLA2 converting LDL into more potent atherogenic Ox-LDL, in vitro

Kumsaiyai Warunee Harte Alison Al-Naji Fadi Al-Daghri Nasser Kyrou Ioannis Barber Thomas Sabico Shaun Tripathi Gyanendra McTernan Philip

¹Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry, UK; ²Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia; ³Human Metabolism Research Unit, WISDEM, UHCW, Coventry, UK.

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The role of glucocorticoid metabolism in bile acid homeostasis

Opiyo Monica Naomi Kenyon Christopher Manwani Kajal Man Tak Seckl Jonathan Andrew Ruth Chapman Karen

Endocrinology Unit, Centre for Cardiovascular Science, Edinburgh University, QMRI, Edinburgh, UK.

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Testosterone differentially regulates lipid and glucose metabolism in visceral and subcutaneous fat in the testicular feminised mouse

Kelly Daniel Muraleedharan Vakkat Akhtar Samia Channer Kevin Jones T Hugh

¹University of Sheffield, Sheffield, UK; ²Barnsley Hospital NHS Foundation Trust, Barnsley, UK; ³Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

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Novel inositol pyrophosphate and insulin sensitivity in response to muscle contraction in glucose intolerant humans

Naufahu Jane Watt Peter Mellish Louise Elliott Bradley Kerekgyarto Anna Mackenzie Richard

¹University of Westminster, London, UK; ²Brighton University, Brighton, UK; ³King’s College Hospital, London, UK.

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Augurin stimulates food intake in male Wistar rats

Patterson Michael Tadross John Suzuki Keisuke Beale Kylie Boughton Charoltte Ghatei Mohammad Bloom Stephen

¹Imperial College, London, UK; ²University of Roehampton, London, UK.

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Abstract unavailable

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Intracellular delivery of therapeutic siRNA via an antennapedia-double stranded RNA binding domain fusion protein as a novel strategy for PTP1B translation attenuation in type 2 diabetes

Tsimon Myrsini Murphy John Barr Alastair

University of Westminster, London, UK.

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Replication of genome wide association-validated loci for type 2 diabetes mellitus in the Saudi Arabian population

Al-Daghri Nasser Alkharfy Khalid Alokail Majed Alenad Amal Al-Attas Omar Mohammad Abdul Khader Sabico Shaun Albagha Omar

¹King Saud University, Riyadh, Saudi Arabia; ²University of South Hampton, South Hampton, UK; ³Warwick Medical School, University of Warwick, Coventry, UK; ⁴University of Edinburgh, Edinburgh, UK.

ePoster Contact

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Cellular consequences for insulin signal transduction of the naturally occurring AKT2 p.Glu17Lys mutation

Minic Marina Rocha Nuno Challis Ben Groeneveld Matthijs Rahilly Stephen O' Semple Robert

Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, Cambridgeshire, UK.

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DPPIV and macronutrients regulate the expression of PYY3[ndash]36 in human gut epithelial cells

Kosicka Anna Renshaw Derek Zariwala Mohammed Gulrez

University of Westminster, London, UK.

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Inflammatory markers in diabetic foot and impact of vitamin D deficiency

Kota Sunil Kumar Meher Lalit Kumar Jammula Sruti Modi Kirtikumar D

¹Medwin Hospital, Hyderabad, Andhrapradesh, India; ²MKCG Medical College, Berhampur, Orissa, India; ³Roland Institute of Pharmaceutical Sciences, Berhampur, Orissa, India.

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The possible involvement of the receptor for advanced glycation end products in vascular senescence in diabetes

Joharatnam Nalinie Yoshimoto Takanobu

¹Tokyo Medical and Dental University, Tokyo, Japan; ²Imperial College London, London, UK.

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Effects of Syzygium aromaticum-derived oleanolic acid administration on postprandial glucose concentration and key intestinal carbohydrate hydrolyzing enzymes of streptozotocin-induced diabetic rats

Hadebe Silindile Dube Sinenkosi Khathi Andile Serumula Metse Myburg Rene Musabayane Cephas T

University of KwaZulu-Natal, KwaZulu-Natal, South Africa.

ePoster Contact

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Unfolded protein response pathway, IRE1[alpha]-XBP1 is altered during adipogenesis in obese human adipocytes

Voyias Philip McCarthy Ciara Antonysunil Adaikala Kumsaiyai Warunee Harte Alison McTernan Philip Tripathi Gyanendra

Warwick Medical School, University of Warwick, Coventry, UK.

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Vitamin D and insulin resistance: no association in healthy overweight people at high risk of cardiovascular disease

Wallace Ian McEvoy Claire Hamill Lesley Ennis Cieran Bell Patrick Hunter Steven Woodside Jayne Young Ian McKinley Michelle

¹Regional Centre For Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK; ²Nutrition and Metabolism Group, Centre for Public Health, Queen’s University Belfast, Belfast, UK.

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Evaluation of efficacy of transdermal delivery of chloroquine on Plasmodium berghei-infected male Sprague[ndash]Dawley rats and effects on blood glucose and renal electrolyte handling

Murambiwa Pretty Tufts Mark Mukaratirwa Samson Van Heerden Fanie R Murabayane Cephas T

University of KwaZulu-Natal, Durban, South Africa.

ePoster Contact

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Altered mitochondrial dynamics in obesity: redressing the balance through bariatric surgery?

McCarthy Ciara Voyias Philip Antonysunil Adaikala Harte Alison Saravanan Ponnusamy Kyrou Ioannis Tripathi Gyanendra McTernan Philip

¹Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry, UK; ²University of Warwick and George Eliot Hospital, Warwick Medical School, Coventry, UK.

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Irisin as a central regulator in energy homeostasis?

Piya Milan K Harte Alison L Sukumar Kavitha James Sean Tripathi Gyanendra Kumar Sudhesh Vatish Manu McTernan Philip G

¹Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry, UK; ²Warwickshire Insitute for the Study of Diabetes, Endocrinology and Metabolsim, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK; ³Division of Reproductive Health, Warwick Medical School, University of Warwick, Coventry, UK; ⁴Department of Pathology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.

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Ileal interposition with diverted sleeve gastrectomy for treatment of type 2 diabetes

Kota Sunil Kumar Ugale Surendra Gupta Neeraj Modi Kirtikumar D

¹Medwin Hospital, Hyderabad, Andhrapradesh, India; ²Kirloskar Hospital, Hyderabad, Andhrapradesh, India.

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Polycystic ovary syndrome has no independent effect on vascular, inflammatory or thrombotic markers when matched for obesity

Kahal Hassan Aburima Ahmed Ungvari Tamas Rigby Alan Dawson Alison Coady Anne-Marie Vince Rebecca Ajjan Ramzi Kilpatrick Eric Naseem Khalid Atkin Stephen

¹Hull York Medical School, Hull, UK; ²Hull and East Yorkshire NHS Trust, Hull, UK; ³University of Hull, Hull, UK; ⁴Leeds Institute for Genetics, Health and Therapeutics, University of Leeds, Leeds, UK.

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Leptin in serum and vitreous humor, and retinal ob mRNA, in human diabetes

Imran Syed A Wilkinson Diane A Tan Alex Y Dickinson John D O'Brien Dan M Samad Arif Wilkinson Michael

¹Obs Gyn, IWK Health Centre, Dalhousie University, Halifax, Canada; ²Division of Endocrinology, VG Hospital, Halifax, Canada; ³Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Canada.

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The endocrine and metabolic characteristics of a large Bardet[ndash]Biedl syndrome clinic population

Mujahid Safa Huda Mohammed Forsythe Elizabeth Hazlehurst Jonathan Tomlinson Jeremy Beales Philip Carroll Paul McGowan Barbara

¹Guy’s and St Thomas’ NHS Foundation Trust, London, UK; ²Queen Elizabeth Hospital, Birmingham, UK.

ePoster Contact

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Maternal B12 insufficiency predicts neonate's metabolic risk factors

Adaikalakoteswari Antonysunil Alexander Lawson Webster Craig Wood Catherine Anderson Neil Sivakumar Kavitha McTernan Philip Tripathi Gyanendra Vatish Manu Saravanan Ponnusamy

¹University of Warwick, Warwick, UK; ²Heartlands Hospital, Birmingham, UK; ³George Eliot Hospital, Nuneaton, UK.

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The use of GLP-1 receptor agonists to manage unwanted weight gain in patients with 'hypothalamic' obesity secondary to structural pituitary pathology

Kyaw Ye Mogford Julianne Hordern Victoria Russell-Jones David

CEDAR Centre, Royal Surrey County Hospital, UK.

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The public distress domain of quality of life correlates directly and independently with BMI in pre-operative morbidly obese patients awaiting metabolic surgery

Aftab Syed Abdus Saboor Reddy N Piya MK Fraser I Menon V Bridgwater S halder L Kendrick D Kumar S Barber TM

¹Warwick Medical School, Warwickshire Institute for Diabetes, Endocrinology and Metabolism, The University of Warwick, Coventry, West Midlands, UK; ²Division of General Surgery, University Hospitals of Coventry and Warwickshire (NHS Trust), Coventry, West Midlands, UK; ³Warwickshire Institute for Diabetes, Endocrinology and Metabolism, University Hospitals of Coventry and Warwickshire (NHS Trust), Coventry, West Midlands, UK.

ePoster

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Pregestational BMI predicts neonatal hypoglycemia in women with gestational diabetes

Ahmad Ayesha Jindal Radhika Siddiqui Mohammad Wangnoo Subhash

¹Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India; ²Indraprastha Apollo Hospital, New Delhi, India.

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Effectiveness of bariatric surgery in women with and without polycystic ovarian syndrome

Kyriacou Angelos Hunter Louise Tolofari Sotonye Syed Akheel

¹Salford Royal NHS Foundation Trust, Salford, UK; ²The University of Manchester, Manchester, UK.

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Octreotide therapy of chronic urticaria and angioedema after gastric bypass procedure

Varghese Jeanny Malik Mohamed Sewell Carrock

Scunthorpe General Hospital, Scunthorpe, UK.

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Prevalence of vitamin D insufficiency in severely obese patients seeking bariatric surgery

Smith Rachel Batterham Rachel Finer Nick

¹Department of Medicine, University College London, London, UK; ²UCL Institute of Cardiovascular Science, London, UK; ³UCLH Centre for Weight Loss, Metabolic and Endocrine Surgery, London, UK.

ePoster Contact

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Appetite regulation during a 6-month military tour to Afghanistan

Hill N E Fallowfield J L Delves S K Brett S J Wilson D R Frost G Dhillo W Bloom S R Murphy K G

¹Imperial College London, London, UK; ²Institute of Naval Medicine, Alverstoke, UK; ³Royal Centre for Defence Medicine, Birmingham, UK.

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Weight loss after bariatric surgery in women of childbearing age

Alatishe Aderinsola Ammori Basil J New John P Syed Akheel A

¹Salford Royal NHS Foundation Trust and University Teaching Hospital, Salford, UK; ²The University of Manchester, Manchester, UK.

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Eating more quickly heightens overall systemic exposure to glucose and NEFA in the post-prandial phase, irrespective of energy expenditure in obese women

Reddy Narendra Peng Chen Piya Milan K Aftab Saboor A S Campbell Alison Hattersley John Halder Louise Harte Alison L Randeva Harpal Tripathi Gyanendra McTernan Philip G Kumar Sudhesh Barber Thomas M

Division of Metabolic and Vascular Health, University of Warwick, Coventry, UK.

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Hepatic 11[beta]-hydroxysteroid dehydrogenase type 1 is elevated following weight loss secondary to bariatric surgery

Woods Conor Taylor Angela Hughes Beverly Corrigan Michelle Stewart Paul Tomlinson Jeremy Shea Donal O Sherlock Mark

¹Education and Research Centre, St Vincent’s University Hospital and St Columcille’s Hospital, Dublin, Ireland; ²Centre for Endocrinology, Diabetes and Metabolism, Institute of Biomedical Research, University of Birmingham, Birmingham, UK; ³Department of Endocrinology, Adelaide and Meath Hospital, Tallaght l, Dublin, Ireland.

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Brown adipose tissue identification in an adult human using IDEAL MRI

Reddy Narendra Jones Terence Wayte Sarah Adesanya Oludolapo Yeo Yen Randeva Harpal Kumar Sudhesh Hutchinson Charles Barber Tom

¹University of Warwick, Coventry, UK; ²University Hospitals of Coventry and Warwickshire, Coventry, UK.

ePoster Contact

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Vitamin D supplementation as influenced by diabetic therapies

Alkharfy Khalid Al-Daghri Nasser Al-Othman Abdulaziz Moharram Osama Alokail Majed Al-Saleh Yousef Sabico Shaun McTernan Philip

¹King Saud University, Riyadh, Saudi Arabia; ²King Abdulaziz University Hospital, Riyadh, Saudi Arabia; ³Warwick Medical School, Warwick University, Coventry, UK.

ePoster Contact

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Association of the incidence of type 1 diabetes with markers of infection and antibiotic susceptibility at country level

Abela Alexia-Giovanna Fava Stephen

¹Diabetes and Endocrine Centre, Mater Dei Hospital, Malta; ²University of Malta Medical School, Msida, Malta.

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A pilot study of 25-hydroxy vitamin D level in type 2 diabetes mellitus with diabetic retinopathy

Abdelsalam Mona

Endocrine, 7 Metabolism Unit, Ain Shams University, Cairo, Egypt.

ePoster

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Non-alcoholic fatty liver disease in patients attending the National Severe Insulin Resistance Service

Leiter Sarah M Sleigh Alison Adams Claire Harris Julie Lomas David J Allison Michael Semple Robert Savage David Stears Anna

¹Metabolic Research Laboratories, University of Cambridge, Cambridge, UK; ²Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK; ³Wolfson Department of Diabetes and Endocrinology, Addenbrookes Hospital, Cambridge, UK; ⁴Department of Radiology, University of Cambridge, Cambridge, UK; ⁵Department of Radiology, Addenbrookes Hospital, Cambridge, UK; ⁶Department of Medicine, Addenbrookees Hospital, Cambridge, UK.

ePoster Contact

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A study of serum osteocalcin level in women with gestational diabetes mellitus

Abdelsalam Mona

Endocrine, 7 Metabolism Unit, Ain Shams University, Cairo, Egypt.

ePoster Contact

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Short term calorie restriction: effects on endocrine markers of nutritional status

Jain Swati Singh Som Nath

Defence Institute of Physiology and Allied Sciences, Delhi, India.

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The development of a structured education programme to improve cardiovascular risk in women with polycystic ovary syndrome (SUCCESS Study)

Mani Hamidreza Daly Heather Barnett Janette Levy Miles Khunti Kamlesh Howlett Trevor Davies Melanie

¹University of Leicester, Leicester, UK; ²University Hospitals of Leicester, Leicester, UK.

ePoster Contact

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Hypogonadism in males with type 2 diabetes mellitus

Adesanya Adewole

Federal Medical Centre, Lokoja, Kogi State, Nigeria.

ePoster Contact

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Santhakumar Anjali Wahid Shaz Quinton Richard

¹Royal Victoria Infirmary,Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; ²South Tyneside Hospital, South Shields, UK.

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Risk assessment of adult residents in ile-ife, South-Western Nigeria for type 2 diabetes mellitus

Ajani Gbadebo Ikem Rosemary Enikuomehin Adenike Soyoye David Kolawole Babatope

Obafemi Awolowo University Teaching Hospitals’ Complex, Ile-Ife, Osun State, Nigeria.

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Adrenal insufficiency post bariatric surgery

Shankaran Vani Barclay Amanda Cinnadorai Rajeshwaran Thida Myat Srinivasan Balasubramaniyan

St James University Hospital, Leeds, UK.

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Pregnancy outcome in a patient with lipodystrophy and type 2 diabetes

Shonibare Tolulope Butt Muhammad

Huddersfield Royal Infirmary, Huddersfield, UK.

ePoster Contact

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Impaired iron status in severely obese bariatric surgery candidates is multifactorial

Smith Rachel Finer Nick

¹Department of Medicine, University College London, London, UK; ²UCL Institute of Cardiovascular Science, London, UK; ³UCLH Centre of Weight Loss, Metabolic and Endocrine Surgery, London, UK.

ePoster Contact

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What lies beneath: a case of spontaneous hypoglycaemia or glucose transporter type 1 defect disguised as chronic fatigue?

Kumar Mohit Mukherjee Annice Hendriksz Chris

Salford Royal Foundation Trust, Salford, UK.

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Improvement in testosterone post bariatric surgery

Shankaran Vani Barclay Amanda Cinnadorai Rajeswaran Thida Myat Balasubramanian Srinivasan

St James University Hospital, Leeds, UK.

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Prevalence and associated risks for metabolic syndrome in nigerians with type 2 diabetes mellitus

Soyoye David Adebayo Olorunfemi Kolawole Babatope Ikem Rosemary

¹Ladoke Akintola University of Technology Teaching Hospital, Osogbo, Osun, Nigeria; ²Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun, Nigeria; ³Obafemi Awolowo University, Ile-Ife, Osun, Nigeria.

ePoster Contact

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Ethnic specific anthropometric values have been used by the International Diabetes Federation to aid in the diagnosis of the metabolic syndrome: no such values are available for Sub-Saharan Africa including Nigeria

Enang Ofem Essien Okon Fasanmade Olufemi Ohwovoriole Augustine

¹University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria; ²Lagos University Teaching Hospital, Idi Araba/Lagos State, Nigeria.

ePoster Contact

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Preoperative characteristics of morbidly obese patients who achieved at least 50% excess weight loss post-metabolic Surgery

Aftab Syed Abdus Saboor Reddy N Piya MK Fraser I Menon V Bridgwater S Halder L Kendrick D Kumar S Barber TM

¹Warwickshire Institute for Diabetes, Endocrinology and Metabolism, Warwick Medical School, The University of Warwick, Coventry, West Midlands, UK; ²Division of General Surgery, University Hospitals of Coventry and Warwickshire (Nhs Trust), Coventry, West Midlands, UK; ³Warwickshire Institute for Diabetes, Endocrinology and Metabolism, University Hospitals of Coventry and Warwickshire (NHS Trust), Coventry, West Midlands, UK.

ePoster

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Glycaemic variability: does it make a difference in prediabetes?

Paul Thomas Garg Dinesh Shyamasunder Asha Thomas Nihal Jeyaraman Kanakamani Devanithi Nithya Prasanna Samuel

Christian Medical College, Vellore, Tamil Nadu, India.

ePoster Contact

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Unusual case of hypoglycaemia in diabetic patient

Nyunt Aye

Glan Clwyd Hospital, Rhyl, UK.

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withdrawing insulin in a young person