Endocrine Abstracts

Type 1 iodothyronine deiodinase (D1), a selenoenzyme that catalyzes the bioactivation of thyroid hormone, is expressed mainly in the liver. Its expression and activity are modulated by several factors, but the precise mechanism of its transcriptional regulation remains unclear. In the present study, we have analyzed the promoter of human D1 (hDIO1) gene to identify factors that prevalently increase D1 activity in the human liver. Deletion and mutation analyses demonstrated tha...

Introduction: Recent studies have elucidated that C-type natriuretic peptide (CNP), a member of natriuretic peptide family, is a potent stimulator of endochondral bone growth; CNP and its membranous guanylyl cyclase receptor, GC-B are expressed in growth plate, and mice with targeted overexpression of CNP in growth plate exhibit prominent skeletal overgrowth, whereas CNP or GC-B knockout mice develop severely short stature phenotype owing to their impaired endochondral bone gr...

Primary aldosteronism (PA) is a major cause of secondary hypertension. Among PA, the diagnosis of an aldosterone-producing adenoma (APA) is critical because an APA can be cured surgically. Adrenal venous sampling (AVS) is the golden standard test in the diagnosis of an APA, but is available only in specialized medical centers. Meanwhile, aldosterone secretion of an APA is reported to be more sensitive to ACTH than that of idiopathic hyperaldosteronism (IHA) or essential hypert...