Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep1046 | Thyroid (non-cancer) | ECE2016

Exophthalmos as the first manifestation of mantle cell lymphoma of the patient with Hashimoto thyroiditis

Marczewski Krzysztof , Boniek-Poprawa Dorota , Tomaszewski Piotr , Kawałko Agnieszka , Maciejewski Marek

Introduction: The diagnosis of thyroid orbitopathy is based on clinical symptoms and typical changes in laboratory tests confirming thyroid disease. In approximately 5% it is Hashimoto’s thyroiditis. Typical treatment is primarily steroids administered intravenously. But one disease does not exempts the other, and the drugs can not read. Therefore, we would like to present the history of our patient.Case report: 55 year-old man was admitted to the E...

ea0035p54 | Adrenal cortex | ECE2014

Effects of non-physiological concentrations of glucocorticoids on apoptotic cell death of human early hematopoietic stem/progenitor cells: in vitro studies

Kawa Milosz , Piecyk Katarzyna , Sobus Anna , Michalska Agata , Roginska Dorota , Ustianowski Przemyslaw , Syrenicz Anhelli , Machalinski Boguslaw

Objectives: Glucocorticoids (GCs) intervene in different physiological activities in almost all systems of the human organism. However, GCs are also potent inducers of apoptosis in many cell types and tissues. It is known, that glucocorticoid-induced apoptosis affects the musculoskeletal system, circulatory system, nervous system, endocrine system, reproductive system, and the immune system. Nevertheless, the exact mechanisms of GCs action in human normal hematopoiesis are sti...

ea0099ep438 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Obesity-related comorbidities as potential factors influencing features of premature ageing in severely obese patients

Dudek Alicja , Zapała Barbara , Ciszek Karol , Kawa Ilona , Zgliczyński Wojciech , Major Piotr

Background: Obesity poses a considerable threat to health, increasing the likelihood of accompanying conditions such as type 2 diabetes, hypertension, dyslipidemia, and cancer. Ageing results in the accumulation of damaging factors leading to the development of chronic diseases. Inflammation levels, telomere length, level of neurocognitive function, metabolic age serve as acknowledged indicators of biological aging. The prevalence of premature ageing in obesity has been eviden...

ea0035p339 | Developmental Endocrinology | ECE2014

Influence of growth hormone therapeutic supplementation on early hematopoietic stem/progenitor cells in patients with growth hormone deficiency (GHD).

Kawa Milosz , Stecewicz Iwona , Pius-Sadowska Ewa , Paczkowska Edyta , Piecyk Katarzyna , Gawrych Elzbieta , Petriczko Elzbieta , Walczak Mieczyslaw , Machalinski Boguslaw

Objectives: GH plays a crucial role in the regulation of metabolism of human cells. Nevertheless, a direct influence of this hormone on the proliferation, maturation and differentiation of human early hematopoietic stem/progenitor cells (HSPCs) has not been investigated thoroughly. Moreover, certain deviations of hematological parameters, such as anemia or leucopenia, are commonly observed in patients with growth hormone deficiency (GHD) syndrome, which might be substantially ...

ea0070aep39 | Adrenal and Cardiovascular Endocrinology | ECE2020

Effects of endogenous hypercortisolism on selected Angio-miRs expression in humans

Kawa Miłosz , Sobuś Anna , Łuczkowska Karolina , Litwińska Zofia , Bajerski Norbert , Osowicz-Korolonek Lilianna , Cymbaluk-Płoska Aneta , Wnęk Szymon , Dąbkowska Elżbieta , Walczak Mieczysław , Syrenicz Anhelli , Machaliński Bogusław

Background and Aims: Higher cortisol levels are associated with cardiovascular mortality in the elderly resulting from potential angiostatic effects of glucocorticoids (GCs). These features are replicated in patients with endogenous GCs excess (Cushing’s syndrome) as well as with exogenous hypercortisolism due to excessive pharmacological GCs usage. Both groups present the augmented cardiovascular disease event rate. GCs may also adversely influence remodeling after myoc...