Searchable abstracts of presentations at key conferences in endocrinology

ea0019s32 | Polycystic ovarian syndrome (PCOS): when does it start, why and what to do about it? | SFEBES2009

The teenager with polycystic ovarian syndrome (PCOS)

Kelnar Chris

PCOS typically presents in adolescence. Whilst early diagnosis is important, symptoms and signs (anovulatory cycles, menstrual irregularities, acne) reflect a continuum on a background genetic predisposition and can be difficult to distinguish at an early stage from normal adolescent maturation. Major clinical stigmata – persistent menstrual irregularities (oligo- and amenorrhoea) and hirsutism and acne due to hyperandrogenism – can be very distressing.<p class="...

ea0025p263 | Reproduction | SFEBES2011

Endocrine disruptors and their association with male reproductive disorders and testicular dysgenesis syndrome: establishing a xenografting model of human fetal testis development

Mitchell Rod , Saunders Philippa , Childs Andrew , Cassidy-Kojima Claire , Anderson Richard , Wallace Hamish , Kelnar Chris , Sharpe Richard

Testicular dysgenesis syndrome (TDS) is a group of associated conditions (testicular germ cell tumours (TGCT), cryptorchidism, hypospadias and low sperm counts) that are thought to have a common origin in fetal life. Exposure of fetal rats to environmental chemicals such as the endocrine disrupting chemical di(n-butyl) phthalate (DBP) results in a TDS-like syndrome. However, exposed rats do not develop TGCT and the rodent is a poor model in this context. The effects of ...

ea0028p282 | Reproduction | SFEBES2012

The effects of di(n-butyl) phthalate (DBP) exposure on testis cell development/function in human fetal testis xenografts

Mitchell Rod , Childs Andrew , Anderson Richard , van den Driesche Sander , McKinnell Chris , MacPherson Sheila , Wallace W , Kelnar Chris , Saunders Philippa , Sharpe Richard

Background: Endocrine disruption in the human fetal testis by environmental agents has been proposed as a possible cause of testicular dysgenesis syndrome (TDS) comprising male reproductive disorders such as testicular germ cell tumours (TGCT), cryptorchidism, hypospadias and low sperm counts. Exposure of fetal rats to the widely used plasticizer di(n-butyl) phthalate (DBP) results in a TDS-like syndrome due to a reduction in testosterone production. Whether such effects also ...