Searchable abstracts of presentations at key conferences in endocrinology

ea0039oc7.3 | Oral Communications 7 | BSPED2015

Safety and efficacy of atorvastatin treatment in children with familial hypercholesterolaemia

Davis Nikki , Kerr Stephanie

Introduction: Familial hypercholesterolaemia (FH) has a gene frequency of at least 1/500 with >80% those affected remaining unidentified. Affected individuals have elevated LDL levels from birth which is a major cause of treatable premature coronary artery disease. NICE guidance recommends statin treatment from the age of 10 yrs for children with a confirmed diagnosis of FH. We were the first centre in England to have commissioned contact tracing and cascade testing to con...

ea0078p47 | Obesity | BSPED2021

Evaluating a tertiary paediatric multidisciplinary weight management service

Shaunak Meera , Barratt James , Kerr Stephanie , Davis Nikki

Introduction: The Tier 3 paediatric weight management service at University Hospital Southampton comprises a Paediatric Endocrine Consultant, a Clinical Nurse Specialist and Specialist Dieticians. Children may be referred if they have an endocrinopathy, metabolic co-morbidity or obesity syndrome. We offer at least two years of engagement within the service prior to discharge.Service Evaluation: Twenty-six Tier 3 patients were under follow-up between 1<su...

ea0051oc8.1 | Oral Communications 8 | BSPED2017

Hydrocortisone tablets: human factors in manipulation and their impact on dosing accuracy

Webb Emma A , Watson Cameron , Kerr Stephanie , Davies Justin H , Stirling Heather , Batchelor Hannah

Introduction: Exposure to deficient/excess glucocorticoids can lead to long-term health problems in patients with adrenal insufficiency. An age-appropriate low dose hydrocortisone formulation is not available therefore manipulation a 10 mg tablet is required with potential for inaccurate dosing.Aims: To assess the variability in manipulation procedures recommended by healthcare professionals and undertaken by parents/carers. To quantify the dose-variabil...

ea0066oc8.2 | Oral Communications 8 | BSPED2019

Adrenal Insufficiency: hydrocortisone prescribing and sick day rules

Webb Cameron , Stirling Heather , Kerr Stephanie , Davies Justin , Batchelor Hannah , Webb Emma

Introduction: Exposure to deficient/excess glucocorticoids can lead to long-term health problems in patients with adrenal insufficiency. Historically and age-appropriate hydrocortisone formulation has not been available. Adrenal crisis is associated with significant morbidity and mortality.Aims: To assess prescribing practice for oral hydrocortisone and sick day advise across the UK.Methods: Paediatric endocrinologists and parents[...

ea0033oc5.3 | Oral Communications 5 | BSPED2013

Hypoglycaemia success during the insulin tolerance test: a two centre comparison

Besser Rachel , Chen Suet Ching , Knight Emma , McNeil Ethel , Musson Pauline , Fisher Victoria , Kerr Stephanie , Donaldson Malcolm , Davis Nikki , Ahmed Faisal , Shaikh M Guftar , Davies Justin

Introduction: The insulin tolerance test (ITT) is the gold standard method to assess GH and/or ACTH deficiency. Safety concerns with the use of this test were raised more than 20 years ago from overtreatment of hypoglycaemia and consequent cerebral oedema, resulting in some centres using alternative tests. We have re-appraised use of the ITT in a contemporary setting and evaluated: i) timing of the glucose nadir, ii) time to resolution of hypoglycaemia, iii) adverse events and...

ea0085p1 | Adrenal 1 | BSPED2022

Recommendations for hydrocortisone doses for emergency management and peri-operative care for childhood adrenal insufficiency. BSPED consensus guidelines

Mushtaq Talat , Ali Salma , Boulos Nabil , Boyle Roisin , Cheetham Tim , Davies Justin , Elder Charlotte , Gan Hoong-Wei , Hindmarsh Peter , Katugampola Harshini , Kerr Stephanie , Krone Nils , Salomon Estebanez Maria , Shenoy Savitha , Tollerfield Sally , Choong Wong Sze , Regan Fiona

Adrenal insufficiency (AI) is characterised by lack of cortisol production from the adrenal glands which is treated with replacement doses of hydrocortisone. At times of physiological stress there is an increased requirement for exogenous glucocorticoids, which if untreated can lead to an adrenal crisis. Currently there are no unified guidelines for those <18 years old in the UK; this can lead to a substantial variation in the management of AI in both an emergency and peri...