Searchable abstracts of presentations at key conferences in endocrinology

ea0062p41 | Poster Presentations | EU2019

An Interesting case of Transient Graves’ Ophthalmopathy on the background of Hashimoto’s Thyroiditis

Zaman Shamaila , Behary Preeshila , Khalid Neelam , Todd Jeannie

Case History: A 30 year old woman presented with the history of swollen painful eyes for 4 weeks while visiting Italy. She had a background of Hashimoto’s Thyroiditis since 2010 and was treated with levothyroxine 100 mcg once daily. She was given a course of oral steroids for 2 weeks and her thyroxine dose was reduced to 25 mcg once daily in Italy. Since then, her orbital swelling began to improve. She was a non-smoker. On examination, she was noted to have bilateral mild...

ea0062wa10 | Workshop A: Disorders of the hypothalamus and pituitary | EU2019

Abnormal TFTs - a macro-cause for concern

Khalid Neelam , Sharma Aditi , Zaman Shamaila , Todd Jeannie

Prolactinomas are the most common hormone-secreting pituitary tumors. They typically present with hypogonadism, decreased libido, infertility, and gynaecomastia in men. We present an interesting case of a 44-year-old gentleman who was referred to our endocrine clinic for ‘abnormal thyroid function tests’ with a low T4 despite a normal TSH (TSH 2.01, T4 7.5, T3 3.9). He reported a few years’ history of increasing weight gain and lethargy, generalized aches and pa...

ea0062cb9 | Additional Cases | EU2019

To treat or not to treat: Two interesting cases of Alemtuzamab related Thyroid disorder

Zaman Shamaila , Khalid Neelam , Behary Preeshila , Todd Jeannie

Alemtuzumab, a humanized anti-CD52 monoclonal antibody is effective in treating multiple sclerosis. However, it has been associated with thyroid disorder in up to 30–40% patients. While Graves’ disease is the most common disorder (70%), thyroiditis has been reported up to 4.9% cases.Case 1: 34 year old woman with the background of multiple sclerosis and autoimmune hypothyroidism (on levothyroxine 50 mcg OD) was given Alemtuzumab infusion in Jul...

ea0065p99 | Bone and calcium | SFEBES2019

Normocalcaemic primary hyperparathyroidism: a diagnostic dilemma

Zaman Shamaila , Siddiqui Mohsin , Mohsin Zaineb , Khalid Neelam , Todd Jeannie F

Due to availability of easy routine blood testing, normocalcaemic primary hyperparathyroidism is increasingly seen. However, due to its mild nature, it often poses diagnostic difficulties. We present a case of 65 year old gentleman who was diagnosed with osteoporosis in 2015. He had a history of traumatic fractures of tibia, fibula and calcaneum in 2013. He was later diagnosed with unexplained osteoporosis in 2015 (T-score of hip −2.5 and T-score of spine −1.2) and...

ea0065p160 | Endocrine Neoplasia and Endocrine Consequences of Living with and Beyond Cancer | SFEBES2019

Irradiation and endocrinopathies: multiple complications in a single patient

Zaman Shamaila , Khalid Neelam , Mohsin Zaineb , Siddiqui Mohsin , Todd Jeannie F

Endocrinopathies are common complications following cancer therapy and may occur decades later. We present a case of 37 year old lady with a background of chronic myeloid leukaemia (CML) which was treated with sibling allogenic stem cell transplant and total body irradiation in 2002. She was noted to have elevated calcium levels with raised PTH 10 years later. In view of young age, she underwent genetic screening for MEN1 through buccal swab as her lymphocytes were not suitabl...

ea0065p323 | Neuroendocrinology | SFEBES2019

Testosterone replacement exacerbating hyperprolactinaemia in a male patient with macroprolactinoma: A rare complication

Zaman Shamaila , Mohsin Zaineb , Siddiqui Mohsin , Khalid Neelam , Todd Jeannie F

Hypogonadism persisting in males with macroprolactinoma requires exogenous testosterone replacement therapy but this may cause secondary elevations of prolactin. We present a case of a 44 year old gentleman who was diagnosed with macroprolactinoma after being investigated for ‘abnormal thyroid function tests’ with a low T4 and a normal TSH. He reported a few years’ history of increasing weight gain, lethargy, generalised aches and pains, occasional headaches and...

ea0059p208 | Thyroid | SFEBES2018

Clinico-pathological correlation of U3 thyroid nodules: A retrospective review

Ellatif Mostafa , Idowu Oluwagbemiga , Khalid Neelam , Darko Daniel , Lingam Ravi , Tran Tan , Tolley Neil , Khatri Pushpa , Muralidhara Koteshwara

Background: The incidence of thyroid cancer is increasing globally mainly due to increased detection of papillary microcarcinoma. The British Thyroid Association (BTA) guideline (2014) recommends the use of U1-U5 classification on ultrasound to assess thyroid cancer risk. U3 nodules have low, but indeterminate risk and therefore need FNAC. This retrospective review analyses the outcome of U3 nodules in an outer London hospital.Methods: Thyroid ultrasound...