Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep85 | Adrenal cortex (to include Cushing's) | ECE2017

‘Record-breaking hyponatraemia’ with Addison’s disease

Khan Irfan , Cheyne Elizabeth

Addisons disease is a rare but potentially life threatening endocrine disorder. It is well-known for disguising as a variety of presentations before diagnosis. Here we present a case report of Addison’s disease presenting with very severe hyponatraemia. A 35 year old lady was admitted with lethargy, low mood, weight loss and feeling generally unwell for the last 3 months. Six weeks prior to her admission, her GP arranged some routine investigations including U&E which...

ea0034p190 | Neoplasia, cancer and late effects | SFEBES2014

An incidental diagnosis…

Khan Irfan , Lambert Paul

MEN2a is a rare genetic endocrine disorder associated with mutation of RET oncogene on chromosome 10. It involves lesions in thyroid, parathyroid and adrenal glands. Medullary thyroid carcinoma is the pathological hallmark and usually the first presentation of this syndrome.Clinical case: A 64-year-old lady with previous history of hypertension, IHD, and hypercholesterolemia was referred to Endocrine clinic after she was incidentally found to have high c...

ea0082we6 | Workshop E: Disorders of the gonads | SFEEU2022

Role of sonography in the diagnosis of primary amenorrhea - benefits vs pitfalls

Ali Rashid Razan , Iqbal Khan Irfan

A 17 year-old female was referred to Endocrinology with primary amenorrhoea and arrested puberty (B4 PH4 AH2). She reported breast development in line with her peer group and had experienced a single “show” of vaginal spotting aged 15 years. Although guidelines recommend baseline pelvic USS in the investigation of primary amenorrhoea, it generally only adds value in females with high LH+FSH and abnormal karyotype; indeed, it may raise undue concerns of uterine (Mulle...

ea0044ep17 | (1) | SFEBES2016

Please don’t operate on this patient - A case of ‘Adrenaline running high’

Khan Irfan , Hasan Faisal , Lonnen Kathryn

Phaeochromocytomas are rare catecholamine secreting tumours arising from the chromaffin cells of the adrenal medulla. The annual incidence is approximately 0.8 per 100,000 person-years. Most of them are sporadic but in about 25–30% of patients, they are part of a familial disorder. The classic clinical features are episodic headache, sweating and tachycardia (with or without hypertension). However, a minority of patients are asymptomatic. We present a clinical case in whi...

ea0044ep35 | (1) | SFEBES2016

An interesting case of ‘skyrocketing hypercalcaemia’

Khan Irfan , Bashir Jawad , Chau Fong

Disorders of calcium metabolism are common in Sarcoidosis. The frequency of hypercalciuria and hypercalcaemia has been reported as 30–50% and 10–20% respectively. The underlying mechanism is enhanced PTH independent extra-renal production of 1,25-Dihydroxy Vitamin D (Calcitriol) which increase absorption of Calcium from the gut causing hypercalcaemia.A 79 year old lady was admitted with fever, cough and night sweats and was treated for pneumoni...

ea0044ep101 | (1) | SFEBES2016

The curious case of thyroid dysfunction and the monoclonal antibody

Hasan Faisal , Khan Irfan , Lambert A.P.

Alemtuzumab is the first humanised monoclonal antibody. It is used in haematological malignancies. It is associated with secondary autoimmune adverse effects including Grave’s disease, hypothyroidism, Goodpasture’s disease and ITP. We present a case where there was a drastic change in the thyroid biochemistry in a short span of few weeks- from raging free hormone levels to profound hypothyroidism. A 46 year old man was found to have abnormal th...

ea0070ep426 | Thyroid | ECE2020

A rare case of isolated central hypothyroidism with thyroxine malabsorption

Badshah Amit , Khan Irfan , Singhal Parag

Introduction: Hypothyroidism remains a global problem with prevalence of 1–2% in iodine replete areas of the world. Primary or Autoimmune Hypothyroidism remains the most common type of hypothyroidism worldwide. Central (secondary) hypothyroidism (CH) because of pituitary/hypothalamic disorders is a rare cause of hypothyroidism with reported prevalence of 1:20.000 to 1:80.000 in the general population1. This makes CH about 1000 fold rarer than primary hypothyro...

ea0094p356 | Metabolism, Obesity and Diabetes | SFEBES2023

Ketoacidosis with hyperglycemia but not DKA

Khan Irfan , Tauni Rahat , Humayun Khan Huma

We present an interesting case of a 50-year-old woman with previous history of alcohol dependence, depression & oesophagitis who was brought to the emergency department by ambulance with vomiting, back pain and feeling generally unwell. Her GCS was 14/15, HR128/min, RR 32/min, BP 111/60, temperature 35.2 & CBG 11.2mmol. She reported consuming one bottle of Vodka every day. Initial venous blood gas analysis showed severe metabolic acidosis (pH 6.79, HCO3 3, Lactate 15, ...

ea0082we9 | Workshop E: Disorders of the gonads | SFEEU2022

Primary female hypogonadism

Razi Ahmed Shaikh , Ali Mudassir , Devine Kerri , Iqbal Khan Irfan

Female with primary hypogonadism have inadequate function of the ovaries, with impaired production of germ cells (eggs) and sex hormones (oestrogen and progesterone). We recently came across a 22-year old female with short stature in childhood and adulthood she received growth hormone treatment (due to arrested puberty) between 3-5 years of age and further treatment at age of 10 years. She had history of IUGR, primary amenorrhoea, sensorineural deafness, congenitally missing t...

ea0082we12 | Workshop E: Disorders of the gonads | SFEEU2022

"Is there a right time to stop hormone replacement therapy?"

Iqbal Khan Irfan , Ali Rashid Razan , Razi Ahmed Shaikh

A 59-year-old woman with 46XY complete androgen insensitivity syndrome was referred back to our service. She also has history of hypertension and migraines. She was gonadectomised at the age of 15 years and treated with Ethinylestradiol. She married and was able to have enjoyable sex without the need for vaginoplasty or dilators. However, at 54 years she was firmly advised to stop Ethinylestradiol due to satisfactory bone density and “risks of HRT outweighing benefits&#14...