Searchable abstracts of presentations at key conferences in endocrinology

ea0026p331 | Obesity | ECE2011

Enhanced muscle mass by ALA treatment increase myostatin-mediated pathways in adipose tissue

Kwon H S , Hong O K , Lee S S , Kim S R , Yoo S J

Myostatin is expressed predominantly in skeletal muscle and at significantly lower levels in adipose tissue. The loss of myostatin by gene disruption prevents an age-related increase in adipose tissue mass and partially attenuates the obese and diabetic phenotypes. Inhibition of myostatin signaling could be useful to prevent and/or treat obesity and diabetes. Male OLETF and LETO rats as non-diabetic controls were treated with or without ALA (100 mg/kg per day) and/or insulin (...