ea0070ep353 | Pituitary and Neuroendocrinology | ECE2020
Celia Lasca Livia
, Lozovanu Vera
, Kiraly Antonia
, Georgescu Carmen
, Alina Silaghi Cristina
Introduction: Combined pituitary hormone deficiency (CPHD) is characterized by impaired production of pituitary hormones. A possible cause are PROP-1 mutations (prophet of Pit-1 protein). It plays an essential role in the evolution of pituitary cells secreting GH, TSH, LH, FSH, prolactin; some patients may develop late ACTH deficiency. PROP 1 gene mutation is manifested with variable degrees of phenotype-genotype correlation, with growth failure as the first sign detected in e...