Endocrine Abstracts

There is a long-standing belief that over-supply of fatty acids from adipose tissue might underlie insulin resistance and other components of the metabolic syndrome. Elevated NEFA concentrations may cause insulin resistance of glucose metabolism in liver and muscle, increased hepatic VLDL-triacylglycerol production, impaired endothelial function and, perhaps in the longer term, impairment of insulin secretion. Plasma non-esterified fatty acid (NEFA, or free fatty acid) concent...

In humans, glucocorticoids (GC) are implicated in the pathogenesis of obesity and insulin resistance. GCs are regulated at the prereceptor level by 11beta-hydroxysteroid dehydrogenases (11β-HSD). 11β-HSD type 1 (11β-HSD1) predominantly displays oxo-reductase activity, converting cortisone in man, 11-dehydrocorticosterone in rodents, to cortisol and corticosterone respectively – a reaction requiring the cofactor NADPH. The generation of a hexose-6-phosphate ...

Objective: Physiological alterations challenge the assessment of maternal thyroid function in pregnancy. It remains uncertain how the reference ranges vary by week of pregnancy, and how the classification of maternal thyroid disease vary by analytical method and type of thyroid function test.Method: Consecutively collectedserum samples from 6.282 pregnant women in the North Denmark Region, 2011–2013, were used for the measurement of thyrotropin (TS...