Searchable abstracts of presentations at key conferences in endocrinology

ea0044s12.2 | Novel approaches to endocrine neoplasia (Supported by Endocrine-Related Cancer) | SFEBES2016

Novel techniques for nuclide imaging in pituitary and adrenal tumours

Koulouri Olympia

Functional imaging in endocrine disease is now being increasingly used as an aid in the management of challenging cases, where conventional imaging techniques are inadequate/inconclusive. This talk will provide an overview of available nuclide imaging techniques and specifically focus on the use of 11C-Methionine PET in pituitary and 11C-Metomidate PET in adrenal tumours.11C-Methionine PET in pituitary disease</p...

ea0044p38 | Adrenal and Steroids | SFEBES2016

18F-FDG PET-CT combined with 11C-metomidate PET-CT for the successful characterisation of adrenal lesions; proof of utility of a novel imaging strategy in guiding management

Powlson Andrew S , Koulouri Olympia , Cheow HK , Gurnell Mark

Background/aims/method: Evaluation/management of adrenal incidentalomas (AI) is an increasingly prevalent challenge. CT/MRI characteristics may be useful in determining whether a lesion is a benign adenoma and forthcoming ESE-ENSAT guidance suggests a role for 18F-FDG-PET/CT in distinguishing benign vs malignant lesions. We have previously demonstrated the utility of 11C-metomidate (MTO), which binds CYP11B1/B2, in localising aldosterone-producing adenoma...

ea0044ep75 | (1) | SFEBES2016

The challenges to diagnose and differentiate TSHoma from thyroid hormone resistance: a case report

Hamdan Khaliq , Koulouri Olympia , Gurnell Mark , Chatterjee Krishna , Owen Penelope

TSHoma is rare, with an incidence of 1 per million, and <1% of all pituitary tumours. We reported a case involving a 49-year-old female who was first referred to our endocrine unit in 2006 with excessive lethargy and abnormal TFT’s. She was thought to have thyroid hormone resistance for several years until 2015 when she reported having persistent symptoms and further investigation suggested an alternative diagnosis.Results: Ft4=41.6 pmol/l, TSH=...

ea0025p93 | Clinical biochemistry | SFEBES2011

Psychiatric illness: a cause and hurdle to management of nephrogenic diabetes insipidus

Turner Lisa , Tarigopula Giridhar , Koulouri Olympia , Kong Marie-France

A 54-year-old lady with a 27-year history of schizoaffective disorder presented with shaking episodes, polyuria and polydipsia. She was found to have a serum sodium of 157 mmol/l. Of note, she had been on lithium for several years but this had been stopped three months previously as her serum sodium was raised at 156 mmol/l.On admission her lithium level was undetectable, confirming no recent use. Serum osmolality was 343 mOsm/kg and urine osmolality 82 ...

ea0025p193 | Endocrine tumours and neoplasia | SFEBES2011

Prevalence and follow-up of adrenal incidentalomas after CT renal colic

Koulouri Olympia , Turner Lisa , Tarigopula Giridhar , Kong Marie-France

Introduction: CT renal tract is commonly requested by the urologists for suspected renal colic as it is recognized as the most accurate technique for the detection of ureteric stones. However, follow-up of adrenal incidentalomas identified on such scans could pose a challenge for the non-endocrinologist. We investigated the prevalence and follow-up of incidentally discovered adrenal masses after CT renal colic.Methods: We looked through the reports of al...

ea0050p267 | Neuroendocrinology and Pituitary | SFEBES2017

11C-methionine PET can aid localisation of the source of ACTH-dependent Cushing’s syndrome in patients with equivocal or negative conventional imaging.

Tobin Jake , White Louisa , Koulouri Olympia , Bashari Waiel , Powlson Andrew , Gillett Daniel , Cheow Heok , Gurnell Mark

Background: Cross-sectional imaging (e.g. CT/MRI) can not always reliably identify the site of ACTH secretion in Cushing’s disease (CD) or the ectopic ACTH syndrome (EAS). We report our experience of localising the source of ACTH-dependent Cushing’s syndrome, using functional imaging with 11C-methionine positron emission tomography (Met-PET).Methods: Forty consecutive patients with: (i) de novo ...

ea0050p279 | Neuroendocrinology and Pituitary | SFEBES2017

Bilateral Inferior Petrosal Sinus Sampling (BIPSS) reliably differentiates pituitary from ectopic Cushing’s syndrome, but does not predict pituitary tumour location, especially when lateralizing to the right

White Louisa , Tobin Jake , Koulouri Olympia , Powlson Andrew , Bashari Waiel , Koo Brendan , Gurnell Mark

Background: BIPSS is considered the gold-standard procedure for differentiating autonomous pituitary [Cushing’s Disease (CD)] and ectopic ACTH syndrome (EAS) sources of ACTH hypersecretion. A basal (i.e. unstimulated) pituitary:peripheral ACTH ratio >2, and/or a CRH stimulated pituitary:peripheral ACTH ratio >3, have been proposed as indicative of CD, with a range of sensitivities and specificities cited in the literature. Ad...

ea0050p267 | Neuroendocrinology and Pituitary | SFEBES2017

11C-methionine PET can aid localisation of the source of ACTH-dependent Cushing’s syndrome in patients with equivocal or negative conventional imaging.

Tobin Jake , White Louisa , Koulouri Olympia , Bashari Waiel , Powlson Andrew , Gillett Daniel , Cheow Heok , Gurnell Mark

Background: Cross-sectional imaging (e.g. CT/MRI) can not always reliably identify the site of ACTH secretion in Cushing’s disease (CD) or the ectopic ACTH syndrome (EAS). We report our experience of localising the source of ACTH-dependent Cushing’s syndrome, using functional imaging with 11C-methionine positron emission tomography (Met-PET).Methods: Forty consecutive patients with: (i) de novo ...

ea0050p279 | Neuroendocrinology and Pituitary | SFEBES2017

Bilateral Inferior Petrosal Sinus Sampling (BIPSS) reliably differentiates pituitary from ectopic Cushing’s syndrome, but does not predict pituitary tumour location, especially when lateralizing to the right

White Louisa , Tobin Jake , Koulouri Olympia , Powlson Andrew , Bashari Waiel , Koo Brendan , Gurnell Mark

Background: BIPSS is considered the gold-standard procedure for differentiating autonomous pituitary [Cushing’s Disease (CD)] and ectopic ACTH syndrome (EAS) sources of ACTH hypersecretion. A basal (i.e. unstimulated) pituitary:peripheral ACTH ratio >2, and/or a CRH stimulated pituitary:peripheral ACTH ratio >3, have been proposed as indicative of CD, with a range of sensitivities and specificities cited in the literature. Ad...

ea0044p155 | Neuroendocrinology and pituitary | SFEBES2016

Biliary ultrasound and liver function testing in acromegaly before and after 6 months of somatostatin analogue therapy

Cope Rosanne M A , Powlson Andrew S , Case Sarah J , Koulouri Olympia , Gurnell Mark

Background and aims: We have previously reported an increased prevalence of gallbladder polyps in treatment-naive acromegaly when compared with the general population (29 vs 4.6%), with potential implications for future malignant transformation and screening. However, little is known about biochemical markers of liver function in active acromegaly, or in response to treatment. Furthermore, somatostatin analogue (SSA) therapy is associated with the development of gallstones. He...